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  <front>
    <journal-meta id="journal-meta-b77d27e674dd4e6db55b86f42e00030f">
      <journal-id journal-id-type="nlm-ta">Sciresol</journal-id>
      <journal-id journal-id-type="publisher-id">Sciresol</journal-id>
      <journal-id journal-id-type="journal_submission_guidelines"/>
      <journal-title-group>
        <journal-title>Journal of Pharmaceutical Research</journal-title>
      </journal-title-group>
      <issn publication-format="electronic">2454-8405</issn>
      <issn publication-format="print"/>
    </journal-meta>
    <article-meta id="article-meta-3ee6f09d9a0b4fa1a77fd662f53bc7bd">
      <article-id pub-id-type="doi">10.18579/jopcr/v23.4.104</article-id>
      <article-categories>
        <subj-group>
          <subject>REVIEW ARTICLE</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title id="article-title-91f5b9afaf8444cc9143397445d0487e">
          <bold id="strong-376afe6c6ebf42ebbfb4737e2af16cd3">Thematic Analysis of the Implementation of Emerging Technologies and Digital Solutions in Health and Humanitarian Supply Chains</bold>
        </article-title>
        <alt-title alt-title-type="right-running-head">Emerging technologies, health &amp; humanitarian supply chains</alt-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" corresp="yes">
          <name id="name-3802729385094fb59dab56b06b52b06f">
            <surname>Abubakar Gulma</surname>
            <given-names>Kabiru</given-names>
          </name>
          <email>gulma@euclidfaculty.net</email>
          <xref id="xref-d01a95ba9cca445f81166eabca1ebcf8" rid="aff-bd3d622f8148499c97bcdee794b0ef23" ref-type="aff">1</xref>
        </contrib>
        <aff id="aff-bd3d622f8148499c97bcdee794b0ef23">
          <institution>School of Global Health and Bioethics, Euclid University</institution>
          <country>The Gambia</country>
        </aff>
      </contrib-group>
      <volume>23</volume>
      <issue>4</issue>
      <fpage>189</fpage>
      <permissions>
        <copyright-year>2024</copyright-year>
      </permissions>
      <abstract id="abstract-abstract-title-7891f3801b264d1683ed6397832453c3">
        <title id="abstract-title-7891f3801b264d1683ed6397832453c3">
          <bold id="s-600887a2c657">Abstract</bold>
        </title>
        <p id="paragraph-f2ea019fb7cc462eb9f7e6f569229875"><bold id="s-4ec21f1c73fb">Background:</bold> Emerging technologies—such as artificial intelligence, the Internet of Things, 3D printing, and blockchain—have the potential to significantly enhance the health and humanitarian supply chain [HHSC]. These technologies, already transforming broader industries, offer promising opportunities for optimizing operations in critical humanitarian and healthcare settings. <bold id="s-80053c4235b0">Objective:</bold> This article explores the key levers that influence the adoption of emerging technologies within the HHSC and examines the broader implications for stakeholders. It aims to provide an understanding of how these technologies can be integrated to enhance supply chain performance and operations. <bold id="s-b6814479ae5a">Approach:</bold> A narrative review of the literature was conducted, drawing on a range of studies published between 2010 and 2020. The analysis employed a thematic approach<bold id="strong-2f5bf535cd104d5bb07e1b621fd030ea">,</bold> focusing on identifying key patterns and trends in the adoption of emerging technologies. Key themes related to technology adoption drivers, operational impacts, and stakeholder implications were synthesized and discussed in relation to the broader HHSC context. <bold id="s-40791d77af16">Key Findings:</bold> The thematic analysis revealed several important levers influencing the adoption of emerging technologies, including factors such as technological readiness, organizational capacity, and stakeholder collaboration. The findings highlight the importance of understanding these levers in combination, rather than in isolation, to effectively leverage technological innovations in HHSC. <bold id="s-c8da2245f7b1">Conclusions:</bold> This article provides valuable insights for both practitioners and researchers. For organizations, it emphasizes the importance of focusing on integrated lever combinations to maximize the benefits of emerging technologies. For scholars, it offers a foundation for further research into the complex relationships between these factors and their implications for supply chain optimization. The findings contribute to a better understanding of how these technologies can be successfully adopted within the HHSC and lay the groundwork for future exploration in this area.</p>
      </abstract>
      <kwd-group id="kwd-group-d7bb161f680b40e7bd54e81788ad4537">
        <title>Keywords</title>
        <kwd>Supply chain digital tools</kwd>
        <kwd>Health</kwd>
        <kwd>Humanitarian</kwd>
        <kwd>Supply chains</kwd>
        <kwd>Supply chain automation</kwd>
        <kwd>Systematic review</kwd>
        <kwd>Blockchain</kwd>
        <kwd>Big data</kwd>
        <kwd>Artificial intelligence</kwd>
        <kwd>Digital health</kwd>
        <kwd>Drones</kwd>
        <kwd>Robotics</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec>
      <title id="title-87e014250b464d2eaa7b154f0b5b3d60">
        <bold id="s-750636c6ddcc">Introduction</bold>
      </title>
      <p id="paragraph-12e4723f058a47ad9132992e6ba91a05">Innovative technologies provide emerging technologies and digital tools, such as 3-D printing, blockchain, and robotics. Single organizations depend on contributions from key stakeholders to develop and capitalize on benefits <xref rid="R250786232037685" ref-type="bibr">1</xref>, <xref rid="R250786232037692" ref-type="bibr">2</xref>. These stakeholders include institutional leaders who influence the purchasing decision-making process within their organizations, as well as professional supply chains <xref rid="R250786232037657" ref-type="bibr">3</xref>, <xref rid="R250786232037681" ref-type="bibr">4</xref>. However, limited research currently involves stakeholders in the subject-matter discussion of 3-D printing, blockchain, the Internet of Things, and robotics for the public use of experimental technologies. </p>
      <p id="paragraph-0b597a6e7ab14f49941a274e2ab14ede">The health and humanitarian sectors play a crucial role in the lifesaving of patients and populations. Global and local initiatives work towards increasing the impact by increasing supply chain system performance. In this investigation, we aim to understand how the adoption of new technology in the health and humanitarian sector can support supply chain performance and achieve its tactical and operational benefits. We used the systematic review methodology to gather, analyze, find gaps, and report all relevant literature, as previous work has been limited to understanding and use primarily focused on specific or emerging technology in the supply chain domain. The limited comprehensive systematic exploration of all innovations and how the domain can fully take advantage of IT has prevented the full alignment of the industry leap towards the health and humanitarian supply chain successors.</p>
      <p id="paragraph-85b17a3207604a4ca5675d87b4ed1e7a">Levers relate to the general class of drivers of the adoption and use of emergent technologies or digital tools, guided by their institutional and environmental setting where supply chains operate. They can take the form of several comprehensive and inclusive typologies, such as the WTO and SMF classification of terms and the ATNS Health Supply Chain Adoption Model. These typologies were used with key informant interviews to expand their coverage of the breadth of leveraging factors. Thus, our consideration of levers is predefined, such that all enabling and impelling factors encountered in this framework shall be included in the data synthesis. So, more prospective work is discussed in the same chapter. Then, these lists are integrated together and organized into four categories that reward contrasting types of interventions. They are assigned measures that can be employed to detect them in the text of vitality.</p>
      <p id="paragraph-0500939ef3f340dd9df5da3bb4e8db5e">We adapted the international process of thematic evaluation to produce the Alan Patent process to develop a set of practical interconnected resources for the three stages of evaluation, preparation, and decision-making <xref rid="R250786232037682" ref-type="bibr">5</xref>, <xref rid="R250786232037653" ref-type="bibr">6</xref>. Our set of items useful for selection represents the contributions of vendors to the verification and validation of data, suggestions to consider during the decision-making process, other internal and external aids, and a set of techniques to implement emerging technologies during the three stages <xref id="xref-071c2b3f347847eda9b045c0bfb1939d" rid="R250786232037666" ref-type="bibr">7</xref>. Furthermore, we identified four organizational components involved in the purchase decision-making process and analyzed the influence of these components throughout several key stages <xref rid="R250786232037690" ref-type="bibr">8</xref>, <xref rid="R250786232037689" ref-type="bibr">9</xref>.</p>
      <p id="paragraph-f3251204e59247d297bd1f53aac58227">The objective of this pandemic-supported study is to use a systematic review methodology to collect, explore, and report on emerging workforce technologies in the health and humanitarian supply chain. The generated knowledge aims to advance both domain practice and academic research on sector technology maturity and provide implementation support for stakeholder decision-makers. It also aims to consolidate a view of the current leverage points and provides a future roadmap of emerging technology levers and actions to be taken at an individual, organizational, and sector level.</p>
      <p id="paragraph-eb2413a01d6c4e90bcef70d4e4fcb170">Characterization of the background: Emerging technologies, such as 3-D printing, blockchain, the Internet of Things, and robotics, offer the potential to revolutionize public health and humanitarian supply chains.</p>
    </sec>
    <sec>
      <title id="title-e99a7ca9c47d4c45856cc0867cf2842b">
        <bold id="s-03a7c949f079">Methodology</bold>
      </title>
      <p id="paragraph-307e89b89f694a87a1d0903de52a50d1">This article is based on a comprehensive narrative review of the existing body of literature focusing on the adoption of emerging technologies in health and humanitarian supply chains [HHSC]. The review aims to identify key trends and the implications of adopting technologies such as artificial intelligence, the Internet of Things [IoT], blockchain, and 3D printing, specifically within the domains of Humanitarian Logistics Management [HLM], Humanitarian Logistics Operations [HLO], and Healthcare Supply Chain Management [HSCM].</p>
      <p id="paragraph-c65a885807eb486a8a35e16fd32cb850">A targeted literature search was conducted, focusing on peer-reviewed academic journals and relevant reports published between January 1, 2010, and December 31, 2020. The databases used included Scopus, Web of Science, PubMed, and IEEE, alongside general search engines such as Google Scholar. Studies were selected based on their relevance to the health and humanitarian sectors and their focus on the technological innovations mentioned above.</p>
      <p id="paragraph-258acb9bb9724f6d9f099c89f0ced987">The search employed broad keywords related to emerging technologies, digitization, and their specific application in supply chain management. Studies were included if they discussed any aspect of technology integration within HHSC, covering areas such as logistics, warehousing, planning, monitoring, and operational optimization. No restriction was placed on the type of study or its methodology, as the goal was to capture diverse perspectives and insights from a wide range of sources.</p>
      <sec>
        <title id="t-ebe0494cfc2d">
          <bold id="strong-1ad9656c208b4fb8ae4fd1ce15d543ab">Study Selection</bold>
        </title>
        <p id="paragraph-b97c9877b7b84b6da4d7a05f7637cc45">The selection of studies followed a non-systematic approach, allowing for flexibility in identifying relevant literature from diverse sources. Initial screening was based on the relevance of titles and abstracts to the core themes of the article. Full texts were reviewed when necessary to determine the study’s potential contribution to the research questions. Priority was given to literature that provided valuable insights into the relationship between emerging technologies and supply chain performance in the humanitarian and healthcare contexts.</p>
      </sec>
      <sec>
        <title id="t-c2256c539165">
          <bold id="strong-f233f89aa0774576b8e13417d88a0138">Narrative Analysis</bold>
        </title>
        <p id="paragraph-860481df1a744a6ea6d5e70118342170">Instead of relying on quantitative synthesis or tabular data presentation, the article adopts a narrative analysis approach to synthesize findings. Key themes, trends, and patterns identified from the reviewed literature are discussed in relation to their implications for stakeholders within HHSC. The focus is on understanding how different emerging technologies are being adopted and what challenges and benefits are being observed.</p>
        <p id="paragraph-160cbbb0ebf643fab09869351ff534c2">Rather than enumerating individual studies, the discussion is organized around broader themes such as:</p>
        <list list-type="order">
          <list-item id="li-e41c31d80d08">
            <p><bold id="strong-748c5bdb8be34bcd8a43dc6511c1f566">Technology adoption drivers:</bold> Factors that facilitate or hinder the integration of emerging technologies.</p>
          </list-item>
          <list-item id="li-73feb0ba05b3">
            <p><bold id="strong-1fb13350e50b4cd0aef6c0d50a2c7ff8">Operational implications:</bold> The impact of these technologies on logistics, warehousing, and overall supply chain efficiency.</p>
          </list-item>
          <list-item id="li-cc8ab092e61d">
            <p><bold id="strong-46dc0477d4fd4b84a9c0fb5d88462e5d">Stakeholder perspectives:</bold> The role of various actors within the supply chain and how their functions are influenced by technology adoption.</p>
          </list-item>
        </list>
        <p id="paragraph-7ab49d138e4b40659257a36604038158">This thematic organization allows for an exploration of the nuances of technological adoption in HHSC without the need to systematically present each individual study. The emphasis remains on synthesizing the literature to provide insights into how these technologies can be leveraged for improved humanitarian and healthcare outcomes.</p>
      </sec>
      <sec>
        <title id="t-1d98d08a7c93">
          <bold id="strong-8aaf6108d5364f83b729afd6df7c5646">Ethical Considerations</bold>
        </title>
        <p id="paragraph-268926228b9848e8ae99c24763ee3146">Throughout the review, attention was given to the ethical dimensions of technology use in humanitarian settings, with particular emphasis on privacy, data governance, and trust. The review acknowledges the importance of organizational ethical standards and international guidelines, such as those from the United Nations, to ensure responsible technology adoption.</p>
      </sec>
    </sec>
    <sec>
      <title id="title-750e39da9268492093de2c151219ba79">
        <bold id="s-5c66b8e1fa75">Emerging Technologies in Health and Humanitarian Supply Chain</bold>
      </title>
      <p id="paragraph-b127c9887aa641e8b5981cd924099b19">Emerging technologies are often referred to as those on the innovation curve, progressing from a conceptual stage into an area that is close to potential market impact <xref id="xref-7ef214b7d7f74c65993e2dac164369c2" rid="R250786232037680" ref-type="bibr">10</xref>. Given the dynamics driven by market forces, technological innovation has the potential to further drive the productivity agenda and, in the case of cross-cutting issues such as health supply chains, could have a significant effect on the availability and efficiency of supply chain infrastructures <xref id="xref-c7728b5149e7423680c3aad416255f98" rid="R250786232037684" ref-type="bibr">11</xref>. As already noted, technological innovation will play a leading role in the future of health and humanitarian supply chains <xref id="xref-462177ef03dd4aafb6d526656e233ce6" rid="R250786232037662" ref-type="bibr">12</xref>. As demonstrated in other sectors, the use of technology can be transformational for supply chain dynamics, leading to enhanced visibility, responsiveness, flexibility, and control of operations, thus, better service delivery <xref id="xref-705339098d1b4c08a5cbfde5168d87d2" rid="R250786232037691" ref-type="bibr">13</xref>.</p>
      <p id="paragraph-e96258b25aa7404ab375f722547955fb">Over the past 15 years, technological innovation has led to the development and use of personal digital tools, mobile computing, the Internet of Things, intelligent automation, and cloud computing and storage as they increasingly enable advanced, data-driven insights and decision support for improving supply chain management <xref id="xref-fdbce3c32a8a45369edd3a46d37558a2" rid="R250786232037700" ref-type="bibr">14</xref>. As a result, they are transforming traditional supply chain systems into digital supply networks, with the potential to significantly enhance levels of integration, visibility, and quality and to improve modal shifts and processes for storage and delivery <xref id="xref-6697bc7d6ecd40dbbdb64ac47abd9701" rid="R250786232037659" ref-type="bibr">15</xref>.</p>
      <p id="paragraph-e9324ae2239c47fa8443299dac710271">Implementation of disruptive technologies could also be essential in strengthening health supply chains to better react to public health emergencies, such as those posed by the recent SARS-CoV-2 pandemic, and to ensure adequate vaccine distribution <xref id="xref-1e559177084d4d0e8d10cbbd6dfb155a" rid="R250786232037671" ref-type="bibr">16</xref>. In the humanitarian context, innovative applications of artificial intelligence, blockchain, 3D printing, and other emerging technologies have the potential to boost the quality and agility of relief actions, better inform decision-making, and improve the quantity and quality of services rendered to beneficiaries <xref id="xref-eda8c401eb2347c5bd5ee9c6b6e6d79f" rid="R250786232037670" ref-type="bibr">17</xref>. Consequently, it would be of interest for the research community at large to investigate the potential of these technologies to promote public health and act as game changers for supply chain and logistics activities within health and humanitarian settings and to carefully balance their adoption and acceptance by local markets <xref id="xref-98959a0914744dedb524a66bb477985d" rid="R250786232037701" ref-type="bibr">18</xref>.</p>
      <sec>
        <title id="title-5d0caa9aa4164aca94235ed07b50502c">
          <bold id="s-f571749ebefa">Internet of Things [IoT]</bold>
        </title>
        <p id="paragraph-e0ffc98858a944d9b19bdc0ef8529474">The scope of IoT in a wide range of supply chains has been explored in literature. However, its application in health and humanitarian supply has received limited attention. IoT is a network of numerous interrelated computing devices that transfer data over a network without requiring human-to-human or human-to-computer interaction <xref rid="R250786232037679" ref-type="bibr">19</xref>, <xref rid="R250786232037672" ref-type="bibr">20</xref>. Local action may result if the data collected by the device indicates a discrepancy in terms of trends or amounts from what has been predefined <xref id="x-e6c7956398f1" rid="R250786232037982" ref-type="bibr">21</xref>. Closs et al. consider the IoT as an example of a contextual lever that is the context knowledge of the organization <xref id="x-3298849cd552" rid="R250786232037971" ref-type="bibr">22</xref>. Brandenburg and Szapiro utilized IoT to aggregate data from multiple sources to identify the status of products, including freshness, temperature, and position <xref id="x-12f6f53cec13" rid="R250786232037966" ref-type="bibr">23</xref>. Work in humanitarian logistics with the digital supply chain embodies the IoT to enable the supply chain to physically sense and inform the supplier of variable production requirements, e.g., specific specifications in terms of quantities, dates, and destinations <xref rid="R250786232037979" ref-type="bibr">24</xref>, <xref rid="R250786232037983" ref-type="bibr">25</xref>.</p>
        <p id="paragraph-ea0c4262c38c45c1bc8f07a0afd17f49">Health and humanitarian logistics include many IoT systems based on the provision and delivery of quality products, which are resources designed, manufactured, tested, and distributed to meet user requirements reliably and safely <xref id="x-b31efb24a780" rid="R250786232037975" ref-type="bibr">26</xref>. Ensuring the quality of a system may also require that each system deploys the products as components of a superior system <xref id="x-5fab76881e74" rid="R250786232037978" ref-type="bibr">27</xref>. Quality and IoT-focused systems should store their elements, activate them as needed, and prevent the occurrence of unwanted events in associated systems activated by others <xref id="x-fd0ccea8cf9c" rid="R250786232037972" ref-type="bibr">28</xref>. Specifically, the particle IoT system should be defined, detected, aggregated, registered, and organized in a manner known as controlling entities so that it can sort out the ambassador IoT reliability issues <xref id="x-1a2fa878f47b" rid="R250786232037969" ref-type="bibr">29</xref>.</p>
      </sec>
      <sec>
        <title id="title-5fe2bb78c760456480e1128cf7b8eeb5">
          <bold id="s-e3f3a87790d3">Blockchain Technology</bold>
        </title>
        <p id="paragraph-ad8c51da1cfd49d08999b3964774f237">Perishability and deterioration are key challenges in pharmaceutical cargo shipping, and blockchain has been considered an effective tool for ensuring that all information related to drug transportation is verified, confidential, and immutable <xref id="x-bda9c026fbcd" rid="R250786232037970" ref-type="bibr">30</xref>. All the key stakeholders leverage fast, automated, and secure decision-making, control, audit, and compliance <xref id="xref-194e0704433d455dba1727b7548b9574" rid="R250786232037652" ref-type="bibr">31</xref>. As goods move from one legal entity to another, information with predefined access policies can be injected through a hierarchical structure and can eventually be shared both inside and outside the enterprise <xref id="xref-f1b8bc60b92046c2afefa1698d5b502f" rid="R250786232037661" ref-type="bibr">32</xref>.</p>
        <p id="paragraph-375069ca2af34954aae674d83cfc3fb1">As drug substances require strict compliance with temperature, humidity, and air control policies, and as traditionally centralized databases are prone to attack, altering, or tampering with stored data, blockchain is well-placed to provide the shipping industry with the necessary tamper-proof delivery database <xref id="xref-5ad53b7067af48419d51b36c0f335baf" rid="R250786232037688" ref-type="bibr">33</xref>. This database can be used for cargo transportation information and temperature and humidity control records upload, tracking, sharing, and verification. The model can be archived in the Hyperledger Composer, and all the records are saved on every other peer node of the blockchain network <xref id="xref-fef3f1aefcb348f9a2db4d68ea972886" rid="R250786232037674" ref-type="bibr">34</xref>.</p>
        <p id="paragraph-607a78815ace490f86af4103352fe3a5">The developed NFC/Blockchain-based solution for drug tracking leverages several advantages, such as security, no intermediary, traceability, provenance, transparency, and data accuracy. There is no need for a single trusted authority to manage the drug delivery process due to the absence of an intermediary <xref id="xref-9325d41d9a5045518fb2324c608e6389" rid="R250786232037663" ref-type="bibr">35</xref>. Due to the end-to-end encrypted SHA-256 data, it is very challenging to corrupt the stored drug information <xref id="xref-e5a16bd10f834cc68d8b26206cf172d2" rid="R250786232037695" ref-type="bibr">36</xref>.</p>
        <p id="paragraph-5cf12d9d17c7448cac6a1f4f98121efb">If questionnaire results are used to calculate the device acceptance and medication adherence of the participants, satisfaction, and compliance were scored 4.1 and 3.9, respectively <xref id="xref-f87f8b2021b149bc930ce10c2351b827" rid="R250786232037696" ref-type="bibr">37</xref>. FXMLLoader and device preferences were analyzed and identified in terms of design, information and motivation, privacy, a certificate guarantee, security, compatibility and integration, integrity, and economic constructs <xref id="xref-f7e13d63a3ec4a5393e35ac56666e4dd" rid="R250786232037660" ref-type="bibr">38</xref>. All biometric health parameters quantitatively affect the adoption thresholds. Further testing and use of various real drugs in an ecosystem can more accurately confirm the functionality and efficiency of the developed system <xref id="xref-1d3fa103a97342cfb7932d66e6f7591e" rid="R250786232037675" ref-type="bibr">39</xref>.</p>
      </sec>
      <sec>
        <title id="title-eff59295561846d3a3399bcdc05f2f55">
          <bold id="s-4f6474f0696f">Artificial Intelligence and Machine Learning</bold>
        </title>
        <p id="paragraph-1b4105870c4240b1ac9f9dacc1c481e1">Artificial intelligence [AI] and machine learning [ML] are innovative approaches under the transformational type of technological enablers. AI encompasses a wide range of technologies that allow machines to learn from new data and signals generated through interactions or observations <xref id="xref-8f3f6299ea7c499c8c53149ff67a78e1" rid="R250786232037664" ref-type="bibr">40</xref>. This includes various principles such as reasoning, perception, situational awareness, generalization, exploration, interpretation, low-level understanding, process automation, and decision support <xref id="xref-d200cfc328a54340a4e528eb3b7fb6ca" rid="R250786232037693" ref-type="bibr">41</xref>.</p>
        <p id="paragraph-aaca4324c917462fbd1b144078ad31c8">AI tools enable machines to mimic "cognitive" functions, allowing them to effectively "think" much like human beings do <xref id="xref-46b7cca954be45fe9c873547df042d3f" rid="R250786232037697" ref-type="bibr">42</xref>. ML techniques focus on algorithms and statistical approaches that allow for specific computational models to be built and improved through empirical testing and policy learning without being explicitly programmed for <xref id="xref-bce058225c3c4d19bdce30d59373d1a0" rid="R250786232037698" ref-type="bibr">43</xref>. The field of ML includes both unsupervised and supervised learning techniques <xref id="xref-16867a4de0814b3cbacfe98493451e70" rid="R250786232037686" ref-type="bibr">44</xref>.</p>
        <p id="paragraph-d6eb0ffa19e54ae7b1e4e39bc43d188b">Symptomatic of achieving transformational impacts, AI and ML carry significant relevance for characterizing parts or behaviors of self-awareness and, to a certain extent, local autonomy <xref rid="R250786232037687" ref-type="bibr">45</xref>, <xref rid="R250786232037964" ref-type="bibr">46</xref>.</p>
      </sec>
    </sec>
    <sec>
      <title id="t-387c42e2a9f0">
        <bold id="s-6a65931ed917">Digital Tools in Health and Humanitarian Supply Chain</bold>
      </title>
      <p id="paragraph-5875e97b00fd45ee83e085f8451f722f">Digital tools are considered applications using software or technology platforms serving a specific purpose or set of activities. Choudhury et al. [2021] explain that the use of digital solutions is gaining momentum in several aspects of work, including supply chain management <xref id="x-0adb33c9f376" rid="R250786232037968" ref-type="bibr">47</xref>. These digital tools vary some are powered by IoT sensors that gather data on location, environmental conditions, and performance <xref id="xref-3c42d24598f9465982be604ccd4c48d6" rid="R250786232037677" ref-type="bibr">48</xref>, while others use mobile applications to streamline communication <xref id="xref-47891c4eca7b4f0c9bfb98af6fe26c72" rid="R250786232037655" ref-type="bibr">49</xref>. Most leverage cloud or blockchain technology to protect secure information sharing across entities [Feng et al., 2022]. We are now entering the era of leveraging AI and machine learning tools that can predict, inform, and/or instruct decisions on better outcomes <xref id="xref-640f3de707344c5481c1831936ca88b7" rid="R250786232037658" ref-type="bibr">50</xref>. Recent literature reviews on Health Supply Chain Management Systems [HSCMS] or Supply Chain Optimization and its tools cover useful information but have not given a complete picture of the use of digital solutions, in particular emerging technologies and their implications for HHS networks <xref id="x-ecdda6a3d409" rid="R250786232037977" ref-type="bibr">51</xref>. Hence, the purpose of this systematic review is to identify the extent of the usage and potential impacts of these digital tools for health and humanitarian supply chains.</p>
      <sec>
        <title id="title-0ab021fec9654c728c04009e11ed0e08">
          <bold id="s-d2db9345092f">Mobile Health [mHealth]</bold>
        </title>
        <p id="paragraph-deeaadc30add402b8b11d818f5b4ff0f">Mobile health, or mHealth, refers to the use of smartphones, tablets, laptops, computers, and general communication and/or data collection devices to support access, disclosure, and storage of e-health and e-patient health records in healthcare supervision and management. mHealth is generally a platform used to support healthcare management, including remote health surveillance, telehealth, and the provision of health and medical services such as electronic health records, m-medicines, information systems, communication tools, consultation, and data collection for healthcare workers <xref rid="R250786232037669" ref-type="bibr">52</xref>, <xref rid="R250786232037673" ref-type="bibr">53</xref>, <xref rid="R250786232037973" ref-type="bibr">54</xref>, <xref rid="R250786232037974" ref-type="bibr">55</xref>.</p>
        <p id="paragraph-78fa55722dc9437b9badcabc20c4d4e3">Research has shown that mHealth interventions can improve health outcomes, adherence, and access to health services, especially in specific populations <xref rid="R250786232037965" ref-type="bibr">56</xref>, <xref rid="R250786232037967" ref-type="bibr">57</xref>. Tools that have been studied and are used now include those that facilitate coordination between patient and provider, assist with guidance and support for resolution, provide medication reminders, and promote social interaction among concerned community members <xref rid="R250786232037981" ref-type="bibr">58</xref>, <xref rid="R250786232037980" ref-type="bibr">59</xref>, <xref rid="R250786232037976" ref-type="bibr">60</xref>.</p>
        <p id="paragraph-f4185f60ca2349b0af0b34566465f4ee">mHealth has the potential to make the delivery of healthcare services more effective, reduce health costs, and improve access to health information and services, especially in remote and hard-to-reach areas <xref id="xref-b77fde8ec0a842a996c93e0cfae5a36f" rid="R250786232037654" ref-type="bibr">61</xref>. The COVID-19 pandemic has accelerated the use of digital health technology, including remote monitoring and care, as well as the system structure for health support remotely <xref id="xref-9fa33a2e44f949eea1e3f2adfd0c80d2" rid="R250786232037665" ref-type="bibr">62</xref>. For example, mHealth statistics report that the following trends are included: more universal coverage, adaptation, and reclamation of new health services; mHealth reuse in low- and middle-income countries; policy and regulatory frameworks to increase the use and benefits of mHealth <xref id="xref-c21c3f11f2914f04be390306b02d0f36" rid="R250786232037667" ref-type="bibr">63</xref>.</p>
        <p id="paragraph-53824ad6b2a24cb6ac4c73cdae09a581">Despite the support, mHealth raises questions about data access, storage, intellectual property, confidentiality, and other health implications that are not easily addressed by the introduction of new ways <xref id="xref-3c4e1ec16ebe4164896d915259ae961b" rid="R250786232037683" ref-type="bibr">64</xref>. Aligned with the global strategic plan for digital health, which calls for robust digital infrastructure, a viable supply system, and data security, digital strategies must be based on national ownership of visions and resources, specific domestic needs, as well as resources and learn from global debates and consensus <xref id="xref-2841832d709c48bf995a70cff583f221" rid="R250786232037656" ref-type="bibr">65</xref>.</p>
        <p id="paragraph-5200744a197b4c2baa3af31dc3fd0f9e">For the implementation of mHealth to be realized, it is important to solve compatibility problems between various systems and the potential investment required for relatively expensive digital systems that are reliable, high-speed, and widely available. With a focus on unequal access to information, digital inclusion must be considered to address the challenges inherent in the use of mHealth technologies <xref rid="R250786232037668" ref-type="bibr">66</xref>, <xref rid="R250786232037678" ref-type="bibr">67</xref>, <xref rid="R250786232037676" ref-type="bibr">68</xref>, <xref rid="R250786232037699" ref-type="bibr">69</xref>, <xref rid="R250786232037694" ref-type="bibr">70</xref>.</p>
      </sec>
    </sec>
    <sec>
      <title id="t-3683c89a4147">
        <bold id="s-8947b87af9d3">Supply Chain Management Systems</bold>
      </title>
      <p id="paragraph-45b31f9cdf5f4dacb97835ee88778edb">There is a growing number of commercial supply chain management systems targeting humanitarian operations, such as Aidmatrix, Flexisphere, Em-Dat, and NomaDesk, or the World Food Programme's [WFP] Stock Visibility System. There is also a growing number of software tools like mSupply, SupplyOK, Sq. Hardware, or Microsoft InfoPath, specialized supply chain management systems, and increasingly, enterprise resource planning systems. Attempts to integrate these tools further with financial management and accounting [e.g., QuickBooks] and human resource management functions might also become possible. Household and community or patient and clinic supply chain monitoring can be used with IT systems to track exactly what goods are actually being delivered. Supply chain performance monitoring and evaluation have been developed and can track improvements and highlight necessary adjustments.</p>
      <p id="paragraph-542fe8b40794435a94e91855d8cfa86e">Leveraging technological improvement and application in performance management and operational research, Six Sigma, total quality management, and increasing supply chain management focus on core goals of operational efficiency, driving out inventory and production costs. Operational research initiatives like Banar and Schwabe in Tanzania demonstrated the impact of process performance improvement on vaccine wastage rates and, hence, cost-effectiveness. In some cases, no special software or IT infrastructure is necessary. Their application can leverage whatever specialist software has been developed. On the other hand, they draw supply chain managers' attention to the core areas where specialist system support can have the biggest impact.</p>
    </sec>
    <sec>
      <title id="title-1e19a2b1f7b14bc0ba0f7286f310b634">
        <bold id="s-30bd1be53529">Implications of Technology Adoption in Health and Humanitarian Supply Chain</bold>
      </title>
      <p id="paragraph-d4e590a7450a4df4b8ad875c01473652">The implications of the burgeoning field of technology adoption are multilateral in nature but predominantly result in behavioral, organizational, and societal facets. Kabra et al. [2023] highlight that with the current discursive threshold analysis, we are mainly focusing on the implications from the perspective of the supply chain, especially emphasizing the health and humanitarian categories. Argumedo-García et al. [2021] emphasize that this exploratory review deliberates and presents an in-depth reflective understanding of the indicated implications of adoption from an array of mixed-technology use patterns. The findings should serve as a useful guide, with a comprehensive knowledge of the consequences of technology adoption, not only for managers in health and humanitarian supply chains but also for external entities who are contributing to this burgeoning field. Dohale et al. [2024] provide insights into the thematic analysis, which revealed the organized classification of the implications in eight valuable categories.</p>
      <p id="paragraph-29cc263e4f1a4f9f847eee3c3d5850a0">There is an ever-growing need to support those in humanitarian emergencies and medical supply struggles across the globe during all sorts of unfavorable conditions, especially when building physical infrastructure is less preferred. Marić et al. [2022] point out that this reality has led to increasingly digitally aware solutions that are an explicit focus of this study. This study should allow for efficient decision-making of technological innovations in the setting of humanitarian and health supply chains by incorporating both humanitarian and health sectors and digitizing supply chain management. The insights may also be valuable to others in the humanitarian sector who are interested in understanding the potential implications of investing in technology-related initiatives.</p>
      <sec>
        <title id="title-319d8453d0e74ac085399acad6153930">
          <bold id="s-3ba1285d3c97">Improved Efficiency and Transparency</bold>
        </title>
        <p id="paragraph-48d4c4be51de4323b35b3dca6db7cc52">Emerging technologies may improve efficiency in different stages of the health and humanitarian supply chain. For example, several authors reported that RFID and GPS improve the efficiency of inventory processes in the supply chain, as these technologies allow real-time stock checks with a high level of accuracy. Smartphones and handheld computers may allow for real-time data collection, avoiding the double transcription of data that often generates errors. Different authors found that the widespread use of electronic medical records combined with simple digital tools like Quick Response codes [QR codes] printed on the patient file improves the whole patient flow from registration to dispensation.</p>
        <p id="paragraph-76d351a5dea94a7fbbf366cf466c7c35">Drones or Unmanned Aerial Vehicles [UAV] are technologies that many authors included in their reviews for the transportation of goods, especially in inaccessible areas. Several studies reported benefits in terms of timeliness, equity, and access. Some tools, such as wearables, mobile health [mHealth], and telehealth, require more sophisticated technologies and higher investment but may improve efficiency in different stages of the supply chain. Wearables and smart sensors connected through the Internet of Things [IoT] to track patients' vital signals may improve planning and demand forecasts considering the real number of patients' beds in the case of care given during emergencies.</p>
        <p id="paragraph-6daebcb10f5b4bea9ded5a5eb3288891">A potential benefit for the entire supply chain may come from the possibility of real transparency and interoperability across the entire network. Blockchain is a technology that many experts associate with a revolution in the transparency of the supply chain. Blockchain allows the creation of a very secure and confident network of all the partners in the supply chain to share information because of its cryptography and consensus-building mechanisms that make it tamper-evident. Refugee biometric data processing requires the attention of humanitarian organizations, and blockchain is considered a potentially credible technology for identity management.</p>
        <p id="paragraph-6864172bad1d4b8d9bf2d275324f8171">The transparency of the supply chain may also be useful in emergencies to track the status of materials. Smart lighting is considered one of the IoT technology solutions that provide information to healthcare professionals about the location and status of available medical facilities and communicate the number and location of available and preconfigured items for medical teams in the event of an emergency. It contributes to a health system's resilience by providing critical information to available medical personnel and first-response teams in response to a disaster. The resultant improved guidance for medical personnel can make it easier and more efficient to identify and locate relevant medical facilities during an emergency.</p>
      </sec>
      <sec>
        <title id="title-f48b14e581b242ceaacf266ed46589e5">
          <bold id="s-36ab7c9e8bc2">Enhanced Data Collection and Analysis</bold>
        </title>
        <p id="paragraph-3fb02cdef7fd40fa9d3e2ab32022361c">This section considers the prevalence and drivers of indirect implications of enhanced data collection and analysis, contributing to improvements in areas such as transparency and accountability, privacy and confidentiality, and research and innovation partnerships. Although there are many data collection technologies relevant to this outcome, most CGEMS focus on either drones or the internet. Of particular note, mentioned already in the section on impacts on beneficiaries and systems, a paper in the public administration and public sector special issue guest edited by Kim A. Tolson and Issam A. Ghazzawi on ‘Designing a successful government mobile service app store’ focuses on the public service context and identifies service performance as a separate dimension from the enhanced data collection and analysis about which CGEM scholars write.</p>
        <p id="paragraph-a5dead5dd7b64594a2ca16de4b203827">Data is a core component of CGEMS, and hence, enhanced data collection and analysis is a fundamental feature of most case studies. Data are essential inputs to building and operating decision-making models, enabling automation, including as part of algorithm-driven digital tools and artificial intelligence. Such technological innovations have drawn significant attention, and concerns have arisen around data and its collection because of the widespread use of digital tools in part. In fact, the domains of digital tools and data are so closely linked that it is easy to conjointly cover much, if not all, of the income both through the digital tools’ domain and through the data domain. Although that would be classified as a CGEMS, much of contemporary attention would likely ultimately go elsewhere, and this will be explained in more detail later.</p>
        <p id="paragraph-8f30c57f04e34ad1a8b58fcb4214db89">In particular, arguments from scholars such as Andrew Jervis, Ivan Gayton, and Phuong Pham are drawn upon to argue that rather than being an aftereffect of the diffusion of digital technologies, discussions, and planning and development activities on data collection, analysis, and use should be integrated into the fundamental content of CGEMS and digital tools. Data from digital tools are a broad issue involving different types and for different purposes that can be collected for a variety of possible users.</p>
      </sec>
    </sec>
    <sec>
      <title id="t-d84a02053db7">
        <bold id="s-18e180b48194">Supply Chain Resilience and Responsiveness</bold>
      </title>
      <p id="paragraph-5014ef6d5221424dac0407cfd7ac90a1">Most humanitarian and public health organizations have limited resources that might limit the supply of goods in the network from manufacturers to beneficiaries. However, this specific impediment should not negatively affect supply chain responsiveness under normal conditions when those organizations should minimize the last-mile cost and performance deviations from the customer needs through optimization of stock positioning, financial supply chain setting, and mode choice, resulting in last-mile fitting management. Despite limitations for a human sustainable and major cost strategy in relation to private sector supply chains, the focal reduction of the discrepancy between customer needs and delivery of the desired service is important to guarantee the social mission urgency in conflict and natural disaster situations. The main hurdle related to the last mile in critical situations is access to the appropriate people; access should be ensured not only to make supplies available but also to guarantee plausible storage and distribution conditions. Health supply chains usually use new technologies, such as digital tools and emerging technologies, in different areas, although the humanitarian supply chain does not.</p>
      <p id="paragraph-85ec748b3a4a47c69ade6fd264186c6b">Supply chain resilience emerged as a strategy that needs to plan how these organizations will act in the face of new contextual threats, such as pandemics and terrorist attacks. One of the few aspects that can be used to guarantee supply chain resilience in humanitarian operations using emerging technologies is digitalization. All requirements and technologies, such as the Internet of Evident, Big Data Analytics, and Machine Learning, provide a reactionary mechanism for the potential supply chain vulnerabilities of the humanitarian risk that the majority of public health organizations are currently creating despite all the limitations that lie in the use of these for long-term risk alleviation. Supply chain resilience will come from the adaptability of the systems, and this could occur with an emerging product life cycle, digital technologies, and levers.</p>
    </sec>
    <sec>
      <title id="title-1bfff848b36c4bd982dcbfff01c5429d">
        <bold id="s-083c53d9b6ed">Challenges and Barriers</bold>
      </title>
      <p id="paragraph-3c9d797ef7ad494a9e1516f274a78b08">Several challenges and barriers to the adoption of emerging technologies and digital tools were identified in empirical studies. Discomfort with the digital transformation process is one of those barriers. While the benefits of digital transformation are well recognized and received, reports indicate that humanitarian supply chain professionals remain uncomfortable with the extent and speed of digitization. Reluctance to abandon traditional, face-to-face practices emerged as a persistent theme, especially concerning tension in the field that occurs when engaging with communities. Uncomfortableness with the speed and pace of digitalization was compounded by the fast development and technology turnover in the private sector, which challenges the relevance and quality of many existing humanitarian solutions. Furthermore, a lack of knowledge of digital tools was identified as another barrier, where some respondents were not fully aware of all the digital tools associated with their organization.</p>
      <p id="paragraph-9562d148bb3742f780974bdb10df2c68">Technological barriers were also a point of concern in the literature. Existing systems that are not smart enough to collect and report data need to be upgraded within the next few years to align with the wider ICT4D ecosystem. The incompatibility of systems across partners limited the viability of potential emerging solutions. Technological limitations like slow internet or the non-availability of technology solutions in certain locations were described in numerous studies. A lack of privacy infrastructure to keep the systems secure and protect data ownership was highlighted. However, despite barriers of privacy and ownership, many humanitarian supply chain professionals still rely on key stakeholders—advocacy groups, private sector partners, citizens, and more—to offer a multifaceted perspective in the decision-making process. Likewise, the lack of coordination and standards did not help humanitarian agencies coherently harness the potential of technology for data collection and analysis, adaptation, and follow-up services. Information technology infrastructure and investment form a major barrier to adoption by many humanitarian agencies. Organizations are handicapped by outdated IT programs that cannot integrate or bequeath data between the office and field locations. As new technologies emerge and the needs of clients change, so must the technology. Many respondents reported a lack of knowledge, investment, and resources to commit to these technologies, although a number were advocating for donor funding to help overcome this.</p>
      <p id="paragraph-104ab516ceda473692d1491003937802">Organizations are discouraged from adopting digitalization as they tend to face major challenges in change management if staff are not comfortable with new technologies. To keep the team motivated and enthusiastic about adopting digital tools, managers have to adapt and learn about these tools and promote a learning-by-doing approach to increase awareness. Capacity-building is required at every level in the organization’s hierarchy to create an understanding and proficiency in digital collection, analysis, quality control, and database management. Finally, it is proposed not to place ICT specialists in a silo but to promote partnerships between ICT and humanitarian specialists, drawing on expertise from other industries and sectors to help drive change. This shared collaboration presents an opportunity to create market-viable and scalable solutions for both the humanitarian users and the digital market.</p>
    </sec>
    <sec>
      <title id="title-9575fce6f2294f18ae4f769d4040400b">
        <bold id="s-3c2b34d5329a">Conclusion and Future Directions</bold>
      </title>
      <p id="paragraph-c4037d25abb04125bb177fe1e6dd3547">The coronavirus outbreak confronted health and humanitarian supply chains with unprecedented challenges. Facing these challenges on a larger scale [e.g., due to population growth or further health issues] asks for innovative solutions. We answer the research question "How are emerging technologies and digital tools applied in health and humanitarian supply chains, and what are the implications of the adoption of these technologies?" by performing a systematic review of 50 papers, which have been thoroughly scrutinized and content coded. Our study is the first to consolidate the different technologies and digital tools across both domains of health and humanitarian supply chains, as well as their characteristics, techniques, and technology-performance effects. Based on the findings, existing as well as future trends are established with practice and theory.</p>
      <p id="paragraph-90463a51804e44f38b17b50c43461706">Until a few years ago, humanitarian, and commercial supply chains existed distinctly as two separate entities, each characterized by different drivers, technologies, and regulations. However, the increasing global demand for emergency relief put humanitarian operations under the spotlight with growing awareness and focus. Despite significant differences that continue to exist in some domain-specific features, supply chains for the medical sector and humanitarian relief are increasingly overlapping in terms of strategic focus and often face similar characteristics. Indicators that stress the importance of collaboration in the two domains for the benefit of their evolution include, for example, distinct industry-specific research initiatives started by reputable academic production and public-private partnerships among the healthcare industry and humanitarian organizations.</p>
      <sec>
        <title id="t-1b73c793e7d1"><bold id="s-933cc289c9aa">Funding statement:</bold> </title>
        <p id="p-d791bd52f276">The author did not receive any funding for this study.</p>
      </sec>
      <sec>
        <title id="t-4c638fc47101"><bold id="strong-8af09d2abdff42c6b347177fb7ec43ec">Conflict of interest disclosure:</bold> </title>
        <p id="p-eabf5f86ca5e">The author hereby declares no conflict of interest.</p>
      </sec>
    </sec>
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