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Journal of Pharmaceutical Research

Article

Formulation and Evaluation of Solid Lipid Nanoparticles of Etravirine
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Journal of Pharmaceutical Research

DOI: 10.18579/jopcr/v17.4.roopa

Year: 2018, Volume: 17, Issue: 4, Pages: 17-26

Original Article

Formulation and Evaluation of Solid Lipid Nanoparticles of Etravirine

M S Roopa1, Arti Mohan1,∗

1Department of Pharmacy, Krupanidhi College of Pharmacy, Carmelaram, Varthur Hobli, Bengaluru, Karnataka, India

*Corresponding Author
Email: [email protected]

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objectives: Solid lipid nanoparticles (SLNs) are submicron colloidal carriers with an average diameter of nanometers. Owing to their inherent biodegradability and biocompatibility, lipids are now being extensively investigated as carriers for drugs and proteins. The aim of the present study was to formulate and evaluate SLNs containing etravirine, considering the assessment of its poor solubility and low bioavailability from the conventional dosage form. Methods: The formulations were prepared by high-pressure homogenization technique using different lipid-surfactant ratios, while keeping the quantities of the active ingredient constant. Nine different formulations were prepared. The nanoparticles obtained were characterized for particle size analysis, zeta potential analysis, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FTIR), drug content and in vitro drug release profile, stability, and comparative dissolution study of the pure drug and optimized formulation. Findings: Etravirine solid lipid nanoparticle formulations were characterized, and the particle size and surface charge were found to be 234.26 nm and -42.4 mV. The drug loading capacity of the particle was found to be 29.90%, and the in vitro release study of optimized formulations in phosphate buffer pH 6.8 with 1% sodium lauryl sulphate exerted a precise release of 96.48% over a period of 90 min. SEM analysis of the optimized formulation revealed that the particles were slightly spherical. Novelty: Formulation of solid lipid nanoparticles can be easily prepared with adequate physical properties and the required particle size and release characteristics which might be an advantage for oral administration.

Keywords: Etravirine, solid lipid nanoparticles, particle size, zeta potential, entrapment efficiency, drug release

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Copyright

© 2018 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) 

  • 25 September 2024

Year: 2018, Volume: 17, Issue: 4


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