V. G. Brahmbhatt *, N. M. Patel , M. R. Patel , K. R. Patel
- Department of Pharmaceutics, Shri B.M.Shah College of Pharmaceutical Education and Research, Modasa (S.K.), Gujarat - 383 315, India
Abstract
In the present investigation solid dispersion of olanzapine has been prepared to improve its solubility. Further, using solid dispersion, mouth dissolving tablet was prepared to overcome the problem of swallowing. A Simplex Lattice design was applied using three factors, i.e. superdisintegrants like croscarmellose sodium(X1) crospovidone(X2), and sodium starch glycolate(X3) in tablet formulation. Disintegration time and T50 (Time required to 50% drug release) taken as responses. Solid dispersion showed significant enhancement in solubility of olanzapine. For mouth dissolving tablet, batch containing 5% croscarmellose sodium alone had minimum disintegration time (44 sec.) and faster drug release (T50: 40 sec) compared to other batches.
