The objective of this work was to carry out Schirmer's test to assess the lubricating efficacy of the tear substitutes; by using test preparation (containing 0.1% CMC + 0.1 % HPMC) and standard preparation- GlyTears (containing 0.5% HPMC). The study was conducted using healthy New Zealand albino rabbits. From the study it is evident that both the preparations-test as well as standard provides ophthalmic lubrication for quite a long period of time. The test preparation; although containing less amount of polymers as compared to the standard has shown slightly more lubricating efficacy; which is due to the synergistic effect of two polymers.
