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Journal of Pharmaceutical Research

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Development, Optimization, and Evaluation of New Herbal Antipsoriatic Emulgel
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Journal of Pharmaceutical Research

DOI: 10.18579/jopcr/v24.i1.114

Year: 2025, Volume: 24, Issue: 1, Pages: 28-35

Original Article

Development, Optimization, and Evaluation of New Herbal Antipsoriatic Emulgel

Azza Dawoud H Dawoud1,∗, Sali Dawoud Hussien2, Mohammed Abdalbagi1, Mohamed El Hassan Shayoub3

1Medicinal and Aromatic Plants & Traditional Medicine Research Institute, National Center of Research, Sudan
2Department of Dermatology, Faculty of Medicine, Omdurman Islamic University, Sudan
3Department of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Sudan

*Corresponding Author
Email: [email protected]

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Psoriasis is recognized as the most common autoimmune disease caused by the inappropriate activation of the cellular immune system, characterized, by severe skin inflammation, epidermal hyperproliferation, the lack of possible cure and associated severe side effects in allopathic medicines has led to extensive research in natural products with antipsoriatic activity. Aloe sinkatana plant is a very potent antipsoriatic agent and is used traditionally to treat psoriasis. To formulate and evaluate a new emulgel from Aloe sinkatana plant extract used as an anti-psoriatic agent. A 2³ factorial design was selected to formulate Aloe sinkatana Eumlgel. The three factors were: the amount of gelling agent X1, amount of emulsifying agent X2, and amount of liquid paraffin X3, these were selected as independent formulation variables, while the viscosity and spreadability were taken as dependent variables or response variables. The model of the formulation was considered statistically excellent with R² values approaching unity since, the R² values for both the response's viscosity and spreadability were found to be 0.9915, and 0.9761 respectively. The extract of Aloe sinkatana was formulated as an active ingredient in the emulgel dosage form, and formula F3 was selected as an optimal emulgel formula.

Keywords: Aloe sinkatana; Anti-psoriatic; Emulgel; Factorial design; Formulation

References

  1. Gelfand JM, Stern RS, Nijsten T, Feldman SR, Thomas J, Kist J, et al. The prevalence of psoriasis in African Americans: results from a population-based study. Journal of the American Academy of Dermatology. 2005;52(1):23–26. Available from: https://doi.org/10.1016/j.jaad.2004.07.045
  2. Horn EJ, Fox KM, Patel V, Chiou CF, Dann F, Lebwohl M. Association of patient-reported psoriasis severity with income and employment. Journal of the American Academy of Dermatology. 2007;57(6):963–971. Available from: https://doi.org/10.1016/j.jaad.2007.07.023
  3. Kormeili T, Lowe NJ, Yamauchi PS. Psoriasis: immunopathogenesis and evolving immunomodulators and systemic therapies; U.S. experiences. British Journal of Dermatology. 2004;151(1):3–15. Available from: https://doi.org/10.1111/j.1365-2133.2004.06009.x
  4. Almahdi RA. Pharmacovigilance of Herbal Products. Sudan Journal of Rational Use Medicine. 2016;11:29.
  6. Single V, Saini S, Joshi B, Rana AC. Emulgel: a new platform for topical drug delivery. International Journal of Pharma and Bio Sciences. 2012;3(1):P485–P498. Available from: https://www.ijpbs.net/abstract.php?article=MTI1OA==
  7. Mohamed MI. Optimization of chlorphenesin emulgel formulation. AAPS Journal. 2004;6(3):81–87. Available from: https://doi.org/10.1208/aapsj060326
  9. Mona A, Yogesh A, Prakash I, Arun P, Jayshree V, Amruta K. Phytochemical and HPTLC studies of various extracts of Annona squamosa (Annonaceae) International Journal of Pharm Tech Research. 2012;4(1):364–368. Available from: https://www.researchgate.net/publication/267943673_Phytochemical_and_HPTLC_Studies_of_Various_Extracts_of_Annona_squamosa_Annonaceae
  10. Basheer H, Krishnakumar K, Dineshkumar B. Emulgel Formulation: Novel Approach for Topical Drug Delivery System. International Journal for Pharmaceutical Research Scholars. 2016;5(1):227–230. Available from: https://www.ijprs.com/article/emulgel-formulation-novel-approach-for-topical-drug-delivery-system/
  11. Caddeo C, Sales OD, Valenti D, Saurí AR, Fadda AM, Manconi M. Inhibition of skin inflammation in mice by diclofenac in vesicular carriers: liposomes, ethosomes and PEVs. International Journal of Pharmaceutics. 2013;443(1-2):128–136. Available from: https://doi.org/10.1016/j.ijpharm.2012.12.041
  12. Panwar AS, Upadhyay N, Bairagi M, Gujar S, Darwhekar GN, Jain DK. Emulgel: A Review. Asian Journal of Pharmacy and Life Science. 2011;1(3):333–340. Available from: https://shop.tarjomeplus.com/UploadFileEn/TPLUS_EN_3952.pdf
  14. Veni NK, Yashwanthi P, Hemalatha B, Padmalatha K. A Review on Emulgels as a Novel Approach for Topical Drug Delivery. Asian Journal Of Research In Pharmaceutical Sciences. 2022;12(02):163–168. Available from: https://doi.org/10.52711/2231-5659.2022.00028
  16. Ajazuddin AA, Khichariya A, Gupta S, Patel RJ, Giri TK, Tripathi DK. Recent expansions in an emergent novel drug delivery technology: Emulgel. Journal of Controlled Release. 2013;171(2):122–132. Available from: https://doi.org/10.1016/j.jconrel.2013.06.030
  17. Ashara KC, Paun JS, Soniwala MM, Chavada JR, Mori NM, . Micro-emulsion based emulgel: a novel topical drug delivery system. Asian Pacific Journal of Tropical Disease. 2014;4(Supplement 1):S27–S32. Available from: https://doi.org/10.1016/S2222-1808(14)60411-4
  18. Kumar L, Reddy MS, Managuli RS, Pai KG. Full factorial design for optimization, development and validation of HPLC method to determine valsartan in nanoparticles. Saudi Pharmaceutical Journal. 2015;23(5):549–555. Available from: https://doi.org/10.1016/j.jsps.2015.02.001
  19. Khullar R, Kumar D, Seth N, Saini S. Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi Pharmaceutical Journal. 2012;20(1):63–67. Available from: https://doi.org/10.1016/j.jsps.2011.08.001
  20. Yılmaz G, Tanrıverdi ST, Aksu B, Yeğen G, Özer O. Preparation and in vitro characterization of etofenamate emulgels using quality by design. Journal of Research in Pharmacy. 2019;23(6):1033–1039. Available from: https://doi.org/10.35333/jrp.2019.67
  21. Ambala R, Vemula SK. Formulation and Characterization of Ketoprofen Emulgels. Journal of Applied Pharmaceutical Science. 2015;5(7):112–117. Available from: https://dx.doi.org/10.7324/japs.2015.50717
  22. Plumb AP, Rowe RC, York P, Brown M. Optimisation of the predictive ability of artificial neural network (ANN) models: A comparison of three ANN programs and four classes of training algorithm. European Journal of Pharmaceutical Sciences. 2005;25(4-5):395–405. Available from: https://dx.doi.org/10.1016/j.ejps.2005.04.010
  24. Kamble A, Adnaik R, Bhutkar M. Formulation and Evaluation of Itraconazole Emulgel For Topical Drug Delivery. International Journal Of Universal Pharmacy and Bio sciences. 2014;3:37–45.
  25. Mohite S, Salunkhe A. Formulation and evaluation of Emulgel containing Coriandrum sativum seeds oil for Anti-inflammatory activity. Journal of Drug Delivery and Therapeutics. 2019;9(3-s):124–130. Available from: https://dx.doi.org/10.22270/jddt.v9i3-s.2808
  27. Yapar EA, Ýnal Ö, Erdal MS. Design and in vivo evaluation of emulgel formulations including green tea extract and rose oil. Acta Pharmaceutica. 2013;63(4):531–544. Available from: https://dx.doi.org/10.2478/acph-2013-0037
  28. Shelke O, Kulkarni A. Formulation, Development and Evaluation of Nifedipine Emulgel for Treatment of Anal Fissures Using Polymeric Emulsifiers. Indian Journal of Pharmaceutical Education and Research. 2019;53(2s):s74–s81. Available from: https://dx.doi.org/10.5530/ijper.53.2s.51
  29. Goyal S. Novel Anti-Inflammatory Topical Herbal Gels Containing Withania somnifera and Boswellia serrata. International Journal of Pharmaceutical & Biological Archive. 2011;2(4):1087–1094 . Available from: http://www.ijpba.info/ijpba/index.php/ijpba/article/view/339
  30. Ashara KC, Paun JS, Soniwala MM, Chavada JR, Mori NM. Micro-emulsion based emulgel: a novel topical drug delivery system. Asian Pacific Journal of Tropical Disease. 2014;4:S27–S32. Available from: https://dx.doi.org/10.1016/s2222-1808(14)60411-4
  31. Coneac G, Vlaia V, Olariu I, Muţ AM, Anghel DF, Ilie C, et al. Development and evaluation of new microemulsion-based hydrogel formulations for topical delivery of fluconazole. AAPS PharmSciTech. 2015;16(4):889–904. Available from: https://doi.org/10.1208/s12249-014-0275-8
  32. Ali SM, Yosipovitch G. Skin pH: from basic science to basic skin care. Acta Dermato-Venereologica. 2013;93(3):261–267. Available from: https://doi.org/10.2340/00015555-1531

Copyright

© 2024 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) 

  • 23 March 2025

Year: 2025, Volume: 24, Issue: 1


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