Floating Microspheres - An Excellent Approach for Gastric Retention

Preeti Sudheer; Hemanth Kumar; Litha Thomas; D  R  Nethravathi

doi:10.18579/jpcrkc/2015/14/4/89442

Article

Floating Microspheres - An Excellent Approach for Gastric Retention

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Journal of Pharmaceutical Research

DOI: 10.18579/jpcrkc/2015/14/4/89442

Year: 2015, Volume: 14, Issue: 4, Pages: 71-80

Original Article

Floating Microspheres - An Excellent Approach for Gastric Retention

Preeti Sudheer *, Hemanth Kumar , Litha Thomas , D. R. Nethravathi

Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Bangalore - 560 035, Karnataka, India

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Background: The gastro-retentive system is one of the promising oral drug delivery system due to its ability to remain in the gastric region for a longer period. This helps in improving the bioavailability by increasing the solubility and reducing drug wastage.Approach: Various approaches have been put forward to achieve the gastro-retentive property. Among them, floating (hollow) microsphere is the most prominent approach.Findings: Hollow microspheres are spherical free flowing powders in the size range of 1-1000 ?m without core. It is prepared using proteins or synthetic polymers. This buoyant system improves gastric retention, sustains the drug release, and hence reduces the fluctuations in plasma drug concentration.Conclusion: This review presents an insight into recent advances in methods of fabrication, evaluation and applications of hollow microspheres as gastro-retentive drug delivery systems.

References

Gholap SB, Bannerjee SK, Gaikwad DD, Jadhav SL, Thorat RM. Hollow microsphere: A review. Int J Pharm Sci Res. 2010; 1(1):74-79.

Chawla G, Gupta P, Koradia V and Bansal A. A means to address regional variability in intestinal drug absorption. Pharma Tech. 2003; 27(2):5068.

Goyal MK and Mehta SC. Preparation and evaluation of calcium silicate based floating microspheres of amoxicillin. J Appl Pharm Sci. 2011; 1(05):137-141.

Shah SH, Patel JK, Patel NV. Stomach specific floating drug delivery system: A review. Int Pharm Tech Res. 2009; 1(3): 623-633.

Mathur P, Saroha K, Syan N, Verma S, Kumar V. Floating drug delivery system: an innovative acceptable approach in gastroretentive drug delivery. Int J Pharm Biol Sci. 2010; 2 (2):257270.

Jamil F, Kumar S, Sharma S, Vishvakarma P. Singh L. Review on stomach specific drug delivery systems: development and evaluation. Int J Res Pharm Biomed Sci. 2011;2(4):14271433.

Sharma V, Singh L, Sharma V. A novel approach to combat regional variability: floating drug delivery system. Int J Pharm Sci Rev Res. 2011;8(2):154-159.

Rouge N, Allemann E, Gex-Fabry M, Balant L, C o l e E T, B u r i P, e t a l . , C o m p a r a t i v e pharmacokinetic study of a floating multiple-unit capsule, a high density multiple unit capsule and an immediate-release tablet containing 25 mg atenolol. Pharm Acta Helbetiae. 1998;73:81-7.

Streubel A, Siepmann J, Bodmeier R. Multiple unit gastro retentive drug delivery: a new p r e p a r a t i o n m e t h o d f o r l o w d e n s i t y microparticles. J Microencapsul. 2003; 20:32947.

Goole J, Vanderbist F, Aruighi K. Development and evaluation of new multiple-unit levodopa sustained-release floating dosage forms Int J Pharm. 2007;334: 35-41.

Sharma S, Pawar A. Low density multiparticulate system for pulsatile release of meloxicam. Int J Pharm. 2006; 313:150-58.

Klausner EA, Lavy E, Friedman M, Hoffman A. Expandable gastro retentive dosage forms. J Control Release. 2003; 90:143-62.

Deshpande AA, Shah N, Rhodes CT, Malik W. Development of a novel controlled release system for gastric retention. Pharm Res. 1997;14:815-19.

Park K. Enzyme-digestible swelling as platforms for long term oral drug delivery: synthesis and characterization. Biomaterials.1988; 9:435.

Fujimori J, Machida Y, Nagai T. Preparation of a magnetically-responsive tablet and configuration of its gastric residence in beagle dogs. STP Pharma Sci. 1994; 4:425-30.

Guyton AC. Movement of food through the alimentary tract. in: human physiology and mechanisms of disease, London: W.B. Saunders Co;1982.

Nayak AM, Maji R, Das B. Gastroretentive drug delivery systems: a review. Asian J Pharm Clin Res. 2010;3(1):1-10.

Arrora S, Ali J, Khar RK, Baboota S. Floating drug delivery systems: a review. AAPS Pharm Sci Tech. 2005; 6(3):372-90.

Garg S, Sharma S. Gastroretentive drug delivery systems- business briefing. Pharma Tech. 2003: 160-66

Goyal M, Prajapati R, Purohit K, Mehta S. Floating drug delivery system: A review. J Curr Pharma Res. 2011;5(1):7-18.

Tiwari A, Patel G, Virani V. The floating drug delivery system and its impact on calcium channel blocker. Int J Pharma Res & Dev. 2012;12(3): 107-131.

Kadam SM, Kadam SR, Patil U, Ratan G, Jamkandi V. Review on floating drug delivery systems: An approach to oral controlled drug delivery via gastric retention. Int J Res Ayur Pharm. 2011;6 (2):1752-1755.

Katakam V, Somagoni J, Reddy S, Eaga,C. Floating drug delivery systems: a review- Curr Tre Biotech Pharm. 2010; 4(2): 610-647.

Singh BN, Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Contr Rel. 2000; 63: 235-259.

Sharma S, Prashar M, Sahu RK. Floating drug delivery system: incredible revolution. Pharmacology online. 2011; 3:1039- 1054.

Gattani YS. Floating multi particulate drug delivery systems: an overview. Int J Pharma Bio Sci. 2010;2(1):1-14.

Jain K, Rajput R, Dhamal S, Patel K, Agarwal P. Hydrodynamically balanced systems (HBS): Innovative approach of gastro retention: a review. Int J Pharm Tech Res. 2011; 3(3): 14951508.

Garg R, Gupta GD. Progress in controlled gastro retentive delivery systems. Trop J Pharma Res. 2008; 7 (3): 1055-1066.

Wen H, Park. K. Introduction and overview of oral controlled release formulation design, In Wen H, Park. K, editor. Oral controlled release formulation design and drug delivery: Theory to Practice. John Wiley & sons. 2010.p.43-51

Nasa P, Mahant S, Sharma D. Floating systems: A novel approach towards gastro retentive drug delivery system. Int J Pharm and Pharm Sci.2010;2(3):1-7.

Chowdary KPR, Koteshwarara RN, Malathi K. Ethyl cellulose microspheres of glipizide characterization in vitro- vivo evaluation. Ind J Pharma Sci. 2004; 66(4): 412-416.

Surinsi S, Anggirani V, Anware. Study of mucoadhesive microspheres based on pre gelatanised cassava starch succinate as a new carrier for drug delivery. J Med Sci. 2009; 9(6):249-256.

Fischer S, Foreg C, Merkle PH, Gander B. Chitosan coated PLGA-microspheres-a modular system for targeting drug delivery. Euro Cells Mater. 2004; 7:11-12.

Rajalaksmi AN, Buvaneswari B. Short review on Pharmaceutical Microspheres. Inter J Uni Pharma and Life Sci. 2012; 2(2):1-18.

Kavita K, Ashvini VR, Ganesh NS. Albumin microspheres. Unique system as drug delivery carriers for non steroidal anti inflammatory drugs. Int J Pharm Sci Rev Res. 2010; 5(2):10.

Swarbick J, Owen C, Amme H. Surfactants in pharmaceutical products and systems. encyclopedia of pharmaceutical technology. Informa Health Care Inc. 2003; 3(1): 3590.

Dandagi MP, Masthiolimath SV, Gadad PA, Iliger RS. Mucoadhesive microspheres of propanalol hydrochloride for nasal delivery. Ind J Pharma Sci. 2007; 1(3):402-407.

Mathew ST, Devi GS, Prasanth VV, Vinod B. NSAIDs as Microspheres. The internet Journal of Pharmacology.2008; 6(1).

Phalguna Y et al. HPMC Microspheres of zidovudine for sustained release. Inter J Pharm.and Pharmaceut Sci. 2010; 2(4): 41-43.

Patel G, Tiwari A, Rabadia N. Floating microspheres as novel tool for H receptor 2 blocker. IRJP. 2012; 3(2): 45-52.

Al Kassas RS, Gilligan CA, Liwan P. Processing factors affecting particle size and in vitro drug release of sustained release ibuprofen microspheres. Int J Pharm. 1993; 94: 59-67.

Leon Lachmannn, Herbert A. Lieberman. �Theory and practice of industrial pharmacy�. Bombay:Varghese Publishers;2009.

Jain NK. Controlled and novel drug delivery. Delhi: CBS Publishers & Distributors;2004.

Rajput GC, Majmudar DF, Patel KJ, Patel NK, Thakor SR, Patel RR, et al. Floating drug delivery system- A review. Pharm Ext. 2010; 1(1) 43-5.

Jayaprakash S, Halith SM, Firthouse MPU, Kulaturanpillai K, Abhijith, NM. Preparation and evaluation of biodegradable microspheres of methotrexate. Asi J Pharmaceu Sci. 2009;3: 2629.

Tirupati M. et al., Comparative Study of ionotropic gelation technique to entrap diltiazem HCl in mucoadhesive microparticulate system. J. of Pharma. Res. 2010; 3(7):1531-1534.

Pradesh TS et al., Preparation of micro structured hydroxyapatite microspheres using oil in water emulsion. Bulletin Mater. Sci. 2005; 28(5): 383-390.

Harshad P et al., Different methods of formulation and evaluation of mucoadhesive microsphere. Int J Appl Bio Pharma Tech. 2010; 1(3):11571167.

Yadav S et al., Formulation and in vitro and in vivo c h a r a c t e r i z a t i o n o f a c y c l o v i r l o a d e d mucoadhesive microspheres. J of Pharma Sci and Tech. 2011; 3(1): 441-447.

Harsoliya MS., Patel VM., Pathan JK., C. Ankit P. Meenakshi, M. Formulation of floating microspheres of ritonavir by cross linkingtechnique: effect of NaHCO as gas forming 3 agent. Inter J Pharm & Bio Arch. 2012; 3(1):108111.

J. Wells. Pharmaceutical preformulation, the physicochemical properties of drug substances. In: M.E. Aulton (ed), Pharmaceutics- the science of dosage form design. 2nded.; Churchill Livingstone, CN, London. 2002.p.113-138.

Trivedi P, Verma A, Garud N. Preparation and characterization of aceclofenac microspheres. Asian J Pharm. 2008; 2:110-115.

Prakash K, Raju PN, Shanta KK, Lakshmi MN. Preparation and characterization of lamivudine microcapsules using various cellulose polymers. Trop J Pharm Res. 2007; 6(4): 841-847.

Surini S, Anggriani V, Anwar E, Study of mucoadhesive microspheres based on pregelatinsed cassava starch succinate as a new carrier for drug delivery, J Med Sci. 2009; 9(6):249-256.

Kapil K., Rai Ak. Development and evaluation of floating microspheres of curcumin. Trop J Pharm.Res. 2012; 11(5): 713-719.

Jain SK, Awasthi AM, Jain NK, Agrawal GP. Calcium silicate based microspheres of repaglinide for gastro-retentive floating drug delivery: preparation and in vitro characterization. J Control Release. 2005;107:300-309.

Sarode SM, Mittal M, Magar RM. Formulation and evaluation of floating microspheres of Glipizide. J Chem Pharm Res. 2011;3(3):775783.

Soni L.M., Kumar M., Namdeo P.K., Sodium alginate microspheres for extending drug release: formulation and in vitro evaluation. Int J Drug Dev. 2010; 2(1):64-68.

Sarojini S, Manavalan R. An overview on various approaches to gastroretentive dosage forms. Int J Drug Dev & Res. 2011, 4(1): 01-13.

Geneva, ICH guidelines on stability testing of new drug substances and product. Q1A; 2007.

Somwanshi S, Dolas R, Nikam V, Gaware V, Kotade K, Dhamak K, et al. Floating multiparticulate oral sustained release drug delivery system. J Chem Pharm. 2011;3(1):536547.