Arvind Kumar Srivastava 1*, Alok Mukerjee 1, P. W. Ramteke 2, Himanshu Pandey 2, Shanti Bhushan Mishra 1
- Department of Pharmaceutical chemistry, United Institute of Pharmacy, Naini, Allahabad, India
- Department of Pharmaceutical Sciences, SHUATS, Allahabad, India
Abstract
Purpose: This study was aimed to evaluate the antiulcer potential of Cucumis melo var. momordica (Roxb.) Duthie&Fuller, fruits.Methodology: Ethanol and pylorus ligation induced ulcer methods were used in rats for the study. The aqueous and ethanolic extracts (200 and 400 mg/kg body weight) were administered orally and effects on volume of gastric secretions, ulcer index, total and free acidity were evaluated.Findings: A significant dose dependent reduction (P < 0.05) in the acid parameters like ulcer index, gastric volume, free and total acidity and elevation in pH were observed after treatment with 200 and 400 mg/kg extracts in Pylorus ligation and ethanol-induced ulcer models.This reduction in acid-secretary parameters and ulcer score suggesting that acid inhibition accelerates ulcer healing.Conclusion: Based on our findings, we presume that the anti-secretary properties of both extracts were responsible for its anti-ulcer potency. These findings suggest the potential for use of Cucumis melo extract as an adjuvant in the treatment of gastric ulcer.
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