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Journal of Pharmaceutical Research

Article

Mucoadhesive Polymers: A Review
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Journal of Pharmaceutical Research

Year: 2018, Volume: 17, Issue: 1, Pages: 47-55

Original Article

Mucoadhesive Polymers: A Review

Abstract

Purpose: Aim of the study is to explore the concept of mucoadhesion, theories and the various polymers used in mucoadhesive drug delivery. Approach: An extensive review is carried out on mechanism of mucoadhesion, theories, polymers used in mucoadhesive dosage forms and its applications. Finding: Mucoadhesive polymers increases the residence time, prolongs the absorption, enhances solubility and dissolution characteristics of poorly soluble drugs. Conclusion: Mucoadhesive polymers was found to be a novel drug carrier used in buccal, nasal, vaginal, ocular, rectal drug delivery which improves bioavailability of poorly soluble drugs.

References

  • Puratchikody A, Prasanth VV, Mathew ST, Kumar A. Buccal drug delivery: past, present and future-a review. Int J Drug Dev. 2011;3(2):171-175.
  • Miller NS, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv drug deli rev. 2005; 4(2):1666-1691.
  • Ali MF, Bakalis S. Mucoadhesive polymers for food formulation. Procedia food science. 2011;1(1):68-75.
  • Kresmer C, Albrecht K, Greindl M, Wolf C, Debbage P,Schnurch AB. In vivo determination of the time & location of mucoadhesive drug delivery systems disintegration in the gastrointestinal tract. Int J Pharm Sci. 2008; 3(2):638643.
  • Schnurch AB. Mucoadhesive polymers: Strategies, achievements and future challenges. Adv Drug Deliv Rev. 2005;57(11):1553-1555.
  • Khurana S, Madhav NVS. Mucoadhesive drug delivery and method of evaluation. Int J Pharm Bio Sci. 2011;2(1):458-467.
  • Shaikh TA, Shinkar DM, Saudagar RB. Review:Polymers used in the mucoadhesive drug delivery system. Int J Pharm Res Rev. 2016;5(6):45-53.
  • Madhav NVS, Ojha A, Tyagi Y, Negi M. Mucoadhesion: a novelistic platform for drug delivery system. Int J Pharm. 2014; 2(9): 246-58.
  • Kavitha K, Kumar MR, Singh SJ, Mytri G. Novel mucoadhesive polymer � A review. J App Pharm Sci. 2011;1(8):37-42.
  • Saraswathi B, Balaji A, Umashankar MS. Polymersin mucoadhesivedrug delivery system- Latest updates. Int J Pharm Pharm Sci.2013;5(2):423-430.
  • Tangari P, Madhav NVS. Oral mucoadhesive drug delivery systems:A review. Int J Bio Pharm. 2011;2(1):36-46.
  • Andrews GP, Laverty TP, Jones DS. Mucoadhesive plat forms for controlled drug delivery. Eup J Bio Pharm. 2009;71(3):505-518.
  • Singh PK, Singh D, Bijauliya RK. A review on buccal drug delivery system. Int J Res Dev Pharm L Sci. 2017;6(3):26082618.
  • Carvalho FC, Bruschi ML, Evangelista RC, Gremi�o MP. Mucoadhesive drug delivery systems. Brazilian J Pharm Sci. 2010;46(1):1-7.
  • Boddupalli BM, Mohammad znk, Nath R, Banji D. Mucoadhesive drug delivery system:An overview. J Adv Pharm Tech Res. 2010;1(4):381-387.
  • Russo E, Selmin F, Baldassari S, Gennari CGM, Caviglioli G, Cilurzo F, Minghelti P, Parodi B. A focus on mucoadhesive polymers and their application in buccal dosage forms. J Drug Deliv Sci Tech. 2016;32(10):113-125.
  • Naskar S, Roy SKR, Kuotsu K. Drug delivery based on buccal adhesive systems � A review. Int J Pharm Bio Sci. 2013;4(3):240-256.
  • Chatterjee B, Amalina N, Sengupta P, Mandal UK. Mucoadhesive polymers and their mode of action: A recent update. J App Pharm Sci. 2017;7(5):195-203.
  • Duggans S, Cummins W, Donovan OO, Hughes H, Owens E. Thiolated polymers as mucoadhesive drug delivery systems. Eup J Pharm Sci. 2017;100(50):64-78.
  • Boddeda B, Biswal A, Ratna JV. Muco/bioadhesive polymers in buccal drug delivery � A review. Am J Pharm Tech Res. 2013;3(2):32-47.
  • Nagpal N, Bajaj J, Saini G, Kaur L, Sharma K, Arora M. Mucoadhesion : A new polymeric approach. Bull Pharm Res. 2016;6(3):74-82.
  • Miller NS, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Deli Rev. 2005;57(8)1666-1691.
  • Rajput GC, Majmudar FD, Patel JK, Takor RS, Patel BP, Rajgor NB. Stomach specific mucoadhesive tablets as controlled drug delivery system- A review work. Int J Pharm Bio Res. 2010;1(1):30-41.
  • Alexander A, Ajazuddin S, Tripathi DK, Verma T, Mayura J, Patel S. Mechanism responsible for mucoadhesion of mucoadhesive drug delivery system: A review. Int J App Bio Pharm Tech. 2011;2(1):434-435.
  • Madhav NVS, Ojha A, Tyagi Y, Negi M. Mucoadhesion : A novelistic plat form for drug delivery system. Int J Pharm. 2014;2(9):246-258.
  • Nielsen LS, Schubert L, Hansen J. Bioadhesive drug delivery system: characterization of mucoadhesive properties of system based on glyceryl mono-oleate and glyceryl monolinoleate. Eur J Pharm Sci. 1998;3(1):231-239.
  • Rao RKV, Buri PA. Novel in situ method to test polymers and coated microparticles for bioadhesion. Int J Pharm. 1989;52(3):265-270.
  • Suresh P, Manasa K, Sathish BS, Brahmaiah B, Khalilullah S, Sreekanth N. Bioadhesive drug delivery system � A review. Asian J Pharm Res. 2013;3(1):30-37.
  • Patel VM, Prajapati G, Patel M. Mucoadhesive biayer tablets of propranolol hydrochloride. AAPS Pharma Sci Tech. 2007;8(3):234-242.
  • Rathee P, Jain M, Garg A, Nanda A, Hooda A. Gastro intestinal mucoadhesive drug delivery system. A review. J Pharm Res. 2011; 4(5):1488-1453.
  • Davis SS, Hardy JG, Newman SP, Wilding IR. Gamma scintigraphy in the evaluation of pharmaceutical dosage forms. Eur J Nuc Med. 1992;19(11):971-86.
  • Shaikh R, Raj TR, Garland MJ, David W, Donnelly RF. Mucoadhesive drug delivery systems. J Pharm Bio Alli Sci. 2017; 3(1):89-90.
  • Soumya G, Nayyar P, Akanksha B, Kumar SP. Interpenetrating polymer network based drug deliverysystem: emerging application and recent patents. Egypt Pharmaceut J. 2017; 27(34):75-86.

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