Mucoadhesive Polymers: A Review

Anjana anil; Preethi Sudheer

doi:10.18579/jpcrkc/2018/17/1/119566

Article

VIEWS 1229
PDF 669

Journal of Pharmaceutical Research

DOI: 10.18579/jpcrkc/2018/17/1/119566

Year: 2018, Volume: 17, Issue: 1, Pages: 47-55

Original Article

Mucoadhesive Polymers: A Review

Anjana anil *, Preethi Sudheer

Department of Pharmaceutics, 12/1, Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram Post, Varthur (H), Bangalore-560035, India

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Purpose: Aim of the study is to explore the concept of mucoadhesion, theories and the various polymers used in mucoadhesive drug delivery. Approach: An extensive review is carried out on mechanism of mucoadhesion, theories, polymers used in mucoadhesive dosage forms and its applications. Finding: Mucoadhesive polymers increases the residence time, prolongs the absorption, enhances solubility and dissolution characteristics of poorly soluble drugs. Conclusion: Mucoadhesive polymers was found to be a novel drug carrier used in buccal, nasal, vaginal, ocular, rectal drug delivery which improves bioavailability of poorly soluble drugs.

References

Puratchikody A, Prasanth VV, Mathew ST, Kumar A. Buccal drug delivery: past, present and future-a review. Int J Drug Dev. 2011;3(2):171-175.

Miller NS, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv drug deli rev. 2005; 4(2):1666-1691.

Ali MF, Bakalis S. Mucoadhesive polymers for food formulation. Procedia food science. 2011;1(1):68-75.

Kresmer C, Albrecht K, Greindl M, Wolf C, Debbage P,Schnurch AB. In vivo determination of the time & location of mucoadhesive drug delivery systems disintegration in the gastrointestinal tract. Int J Pharm Sci. 2008; 3(2):638643.

Schnurch AB. Mucoadhesive polymers: Strategies, achievements and future challenges. Adv Drug Deliv Rev. 2005;57(11):1553-1555.

Khurana S, Madhav NVS. Mucoadhesive drug delivery and method of evaluation. Int J Pharm Bio Sci. 2011;2(1):458-467.

Shaikh TA, Shinkar DM, Saudagar RB. Review:Polymers used in the mucoadhesive drug delivery system. Int J Pharm Res Rev. 2016;5(6):45-53.

Madhav NVS, Ojha A, Tyagi Y, Negi M. Mucoadhesion: a novelistic platform for drug delivery system. Int J Pharm. 2014; 2(9): 246-58.

Kavitha K, Kumar MR, Singh SJ, Mytri G. Novel mucoadhesive polymer � A review. J App Pharm Sci. 2011;1(8):37-42.

Saraswathi B, Balaji A, Umashankar MS. Polymersin mucoadhesivedrug delivery system- Latest updates. Int J Pharm Pharm Sci.2013;5(2):423-430.

Tangari P, Madhav NVS. Oral mucoadhesive drug delivery systems:A review. Int J Bio Pharm. 2011;2(1):36-46.

Andrews GP, Laverty TP, Jones DS. Mucoadhesive plat forms for controlled drug delivery. Eup J Bio Pharm. 2009;71(3):505-518.

Singh PK, Singh D, Bijauliya RK. A review on buccal drug delivery system. Int J Res Dev Pharm L Sci. 2017;6(3):26082618.

Carvalho FC, Bruschi ML, Evangelista RC, Gremi�o MP. Mucoadhesive drug delivery systems. Brazilian J Pharm Sci. 2010;46(1):1-7.

Boddupalli BM, Mohammad znk, Nath R, Banji D. Mucoadhesive drug delivery system:An overview. J Adv Pharm Tech Res. 2010;1(4):381-387.

Russo E, Selmin F, Baldassari S, Gennari CGM, Caviglioli G, Cilurzo F, Minghelti P, Parodi B. A focus on mucoadhesive polymers and their application in buccal dosage forms. J Drug Deliv Sci Tech. 2016;32(10):113-125.

Naskar S, Roy SKR, Kuotsu K. Drug delivery based on buccal adhesive systems � A review. Int J Pharm Bio Sci. 2013;4(3):240-256.

Chatterjee B, Amalina N, Sengupta P, Mandal UK. Mucoadhesive polymers and their mode of action: A recent update. J App Pharm Sci. 2017;7(5):195-203.

Duggans S, Cummins W, Donovan OO, Hughes H, Owens E. Thiolated polymers as mucoadhesive drug delivery systems. Eup J Pharm Sci. 2017;100(50):64-78.

Boddeda B, Biswal A, Ratna JV. Muco/bioadhesive polymers in buccal drug delivery � A review. Am J Pharm Tech Res. 2013;3(2):32-47.

Nagpal N, Bajaj J, Saini G, Kaur L, Sharma K, Arora M. Mucoadhesion : A new polymeric approach. Bull Pharm Res. 2016;6(3):74-82.

Miller NS, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Deli Rev. 2005;57(8)1666-1691.

Rajput GC, Majmudar FD, Patel JK, Takor RS, Patel BP, Rajgor NB. Stomach specific mucoadhesive tablets as controlled drug delivery system- A review work. Int J Pharm Bio Res. 2010;1(1):30-41.

Alexander A, Ajazuddin S, Tripathi DK, Verma T, Mayura J, Patel S. Mechanism responsible for mucoadhesion of mucoadhesive drug delivery system: A review. Int J App Bio Pharm Tech. 2011;2(1):434-435.

Madhav NVS, Ojha A, Tyagi Y, Negi M. Mucoadhesion : A novelistic plat form for drug delivery system. Int J Pharm. 2014;2(9):246-258.

Nielsen LS, Schubert L, Hansen J. Bioadhesive drug delivery system: characterization of mucoadhesive properties of system based on glyceryl mono-oleate and glyceryl monolinoleate. Eur J Pharm Sci. 1998;3(1):231-239.

Rao RKV, Buri PA. Novel in situ method to test polymers and coated microparticles for bioadhesion. Int J Pharm. 1989;52(3):265-270.

Suresh P, Manasa K, Sathish BS, Brahmaiah B, Khalilullah S, Sreekanth N. Bioadhesive drug delivery system � A review. Asian J Pharm Res. 2013;3(1):30-37.

Patel VM, Prajapati G, Patel M. Mucoadhesive biayer tablets of propranolol hydrochloride. AAPS Pharma Sci Tech. 2007;8(3):234-242.

Rathee P, Jain M, Garg A, Nanda A, Hooda A. Gastro intestinal mucoadhesive drug delivery system. A review. J Pharm Res. 2011; 4(5):1488-1453.

Davis SS, Hardy JG, Newman SP, Wilding IR. Gamma scintigraphy in the evaluation of pharmaceutical dosage forms. Eur J Nuc Med. 1992;19(11):971-86.

Shaikh R, Raj TR, Garland MJ, David W, Donnelly RF. Mucoadhesive drug delivery systems. J Pharm Bio Alli Sci. 2017; 3(1):89-90.

Soumya G, Nayyar P, Akanksha B, Kumar SP. Interpenetrating polymer network based drug deliverysystem: emerging application and recent patents. Egypt Pharmaceut J. 2017; 27(34):75-86.