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Depression and Tension Type Headache: Untangling the Cause and Effects Relationship through HSQ-EV and PHQ-9 in Medical students: A Pan India Study
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Journal of Pharmaceutical Research

DOI: 10.18579/jopcr/v22.3.23.67

Year: 2023, Volume: 22, Issue: 3, Pages: 165-171

Original Article

Depression and Tension Type Headache: Untangling the Cause and Effects Relationship through HSQ-EV and PHQ-9 in Medical students: A Pan India Study

Rajat Mehta1, Varun Pareek1, Susheel Kumar1, Lokendra Sharma1,*, Rajveer Singh Rathore1

1Department of Pharmacology, RUHS College of Medical Sciences, Jaipur

*Corresponding Author
Email: [email protected]

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Depression is a widespread mental disorder, affecting approximately 280 million people globally. It's characterized by persistent low mood and loss of interest in daily activities. Depression disproportionately affects women and is linked to a heightened risk of suicide, making it a significant public health concern. In 2019, it ranked as the largest contributor to mental health-related disability. Another prevalent issue is tension-type headache (TTH), a neurological condition causing a band-like discomfort around the forehead. Headache disorders, including TTH and migraines, were the 14th leading cause of disability worldwide in 2019. Migraines, characterized by severe pain and neurological symptoms, are particularly impactful and prevalent among women and high socio-demographic groups. Recent research has explored the relationship between depression and headaches, revealing a bidirectional association. People with chronic TTH often exhibit higher rates of anxiety and depression. Moreover, individuals with depression have an increased risk of developing migraines or TTH. A Pan-India cross-sectional observational study was conducted across many medical colleges in India between September 11, 2023 and September 28, 2023. A self-administered questionnaire was used to collect data using web-based linkages. Based on these findings, it was established there is positive association between Depression and TTH (p=0.003898, X2=11.09). We found a bidirectional relationship between Depression and TTH. We also found that depressed mood also increases the frequency and intensity of TTH.

Keywords: Depression, Tension - Type Headache, Medical Students, Headache

References

  1. Vos T, Lim SS, Abbafati C, Abbas KM, Abbasi M, Abbasifard M, et al. . Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 :–. Available from: () 2020;396 . The Lancet1025812041222 https://doi.org/10.1016/S0140-6736(20)30925-9
  2. Pearce M, Garcia L, Abbas A, Strain T, Schuch FB, Golubic R. Association Between Physical Activity and Risk of Depression: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2022;79(6):550–559. Available from: https://doi.org/10.1001/jamapsychiatry.2022.0609
  6. Desouky DE, Zaid HA, Taha AA. Migraine, tension-type headache, and depression among Saudi female students in Taif University. Journal of the Egyptian Public Health Association. 2019;94(1):7. Available from: https://doi.org/10.1186/s42506-019-0008-7
  9. Steiner TJ, Stovner LJ, Jensen R, Uluduz D, Katsarava Z. Migraine remains second among the world’s causes of disability, and first among young women: findings from GBD2019. The Journal of Headache and Pain. 2020;21(1):137. Available from: https://doi.org/10.1186/s10194-020-01208-0
  10. Caponnetto V, Deodato M, Robotti M, Koutsokera M, Pozzilli V, Galati C, et al. Comorbidities of primary headache disorders: a literature review with meta-analysis. The Journal of Headache and Pain. 2021;22(1):71. Available from: https://doi.org/10.1186/s10194-021-01281-z
  11. Godoy RR, Godoy SRR, Acebal MR, Bedmar MG. Sensory Thresholds and Peripheral Nerve Responses in Chronic Tension-Type Headache and Neuropsychological Correlation. Journal of Clinical Medicine. 2022;11(7):1905. Available from: https://doi.org/10.3390/jcm11071905
  14. Berry JKM, Drummond PD. Does attachment anxiety increase vulnerability to headache? Journal of Psychosomatic Research. 2014;76(2):113–120. Available from: https://doi.org/10.1016/j.jpsychores.2013.11.018
  15. Scher AI, Lipton RB, Stewart W. Risk factors for chronic daily headache. Current Pain and Headache Reports. 2002;6(6):486–491. Available from: https://doi.org/10.1007/s11916-002-0068-8
  16. Blaauw BA, Dyb G, Hagen K, Holmen TL, Linde M, Wentzel-Larsen T, et al. Anxiety, depression and behavioral problems among adolescents with recurrent headache: the Young-HUNT study. The Journal of Headache and Pain. 2014;15(1):38. Available from: https://doi.org/10.1186/1129-2377-15-38
  17. Meer HAVD, Visscher CM, Engelbert RHH, Mulleners WM, Sanden MWGN–VD, Speksnijder CM. Development and psychometric validation of the headache screening questionnaire – Dutch Version. Musculoskeletal Science and Practice. 2017;31:52–61. Available from: https://doi.org/10.1016/j.msksp.2017.07.001
  18. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606–619. Available from: https://doi.org/10.1046/j.1525-1497.2001.016009606.x
  19. Shrestha O, Karki S, Thapa N, Shrestha KL, Shah A, Dhakal P, et al. Prevalence of migraine and tension‐type headache among undergraduate medical students of Kathmandu Valley: A cross‐sectional study. Health Science Reports. 2022;5(5):747. Available from: https://doi.org/10.1002/hsr2.747
  21. Alkarrash MS, Shashaa MN, Kitaz MN, Rhayim R, Alhasan MM, Alassadi M, et al. Migraine and tension-type headache among undergraduate medical, dental and pharmaceutical students of University of Aleppo: a cross-sectional study. BMJ Neurology Open. 2021;3(2):e000211. Available from: https://doi.org/10.1136/bmjno-2021-000211
  23. Ekenze OS, Ezeala-Adikaibe BA, Orjioke C, Mbadiwe N, Ijoma UN, Onyekonwu C, et al. Prevalence and Pattern of Migraine, Tension Type Headache and Chronic Daily Headache among Medical and Nursing Students in Enugu, South East Nigeria. Health. 2018;10(10):1283–1293. Available from: https://doi.org/10.4236/health.2018.1010099
  24. Stovner L, Hagen K, Jensen R, Katsarava Z, Lipton R, Scher A. The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia. 2007;27(3):193–210. Available from: https://doi.org/10.1111/j.1468-2982.2007.01288.x
  25. Al-Hassanl ES, Al-Mulifi AA, Al-Khudhayr AM, Al-Quraini AW, Al-Omran AM, Al-Musallam EJ, et al. Prevalence of headache in female students in King Faisal University: a questionnaire study. Int J Sci Res. 2013;5(6):256–260. Available from: https://www.ijsr.net/archive/v5i6/NOV164093.pdf
  26. Abduljabbar AJN, Abduljabbar Z, Maqsud AN, Almukhtar BA, Al-Mutairy NM, Sahla SA, et al. Prevalence and risk factors of tension headache among 3rd year female medical students at Taibah University in Saudi Arabia. International Journal of Academic Scientific Research. 2015;3(4):46–53. Available from: https://www.ijasrjournal.org/wp-content/uploads/2016/01/DEC5smodif-15.pdf
  27. Mata DA, Ramos MA, Bansal N, Khan R, Guille C, Angelantonio ED. Prevalence of Depression and Depressive Symptoms Among Resident Physicians: A Systematic Review and Meta-analysis. JAMA. 2015;314(22):2373–2383. Available from: https://doi.org/10.1001/jama.2015.15845
  28. Janke AE, Holroyd KA, Romanek K. Depression increases onset of tension-type headache following laboratory stress. Pain. 2004;111(3):230–238. Available from: https://doi.org/10.1016/j.pain.2004.06.007
  29. Thomson EF, Jayanthikumar J, Agbeyaka SK. Untangling the Association Between Migraine, Pain, and Anxiety: Examining Migraine and Generalized Anxiety Disorders in a Canadian Population Based Study. Headache: The Journal of Head and Face Pain. 2017;57(3):375–390. Available from: https://doi.org/10.1111/head.13010
  30. Breslau N, Davis GC, Andreski P. Migraine, psychiatric disorders, and suicide attempts: An epidemiologic study of young adults. Psychiatry Research. 1991;37(1):11–23. Available from: https://doi.org/10.1016/0165-1781(91)90102-u

Copyright

© 2023 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) 

  • 03 January 2024

Year: 2023, Volume: 22, Issue: 3


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