Synthesis and Evaluation of New 2-(Substituted Phenyl)- 3-[5'-(2'-Oxo-2H-chromen-3'-yl)-1,3,4-Oxadiazol-2-yl]-1, 3-Thiazolidin-4-Ones as Anticonvulsants

N  Siddiqui; S  A  Khan; M  A  Bhat; W  Ahsan

doi:10.18579/jpcrkc/2009/8/1/79536

Article

Synthesis and Evaluation of New 2-(Substituted Phenyl)- 3-[5'-(2'-Oxo-2H-chromen-3'-yl)-1,3,4-Oxadiazol-2-yl]-1, 3-Thiazolidin-4-Ones as Anticonvulsants

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Journal of Pharmaceutical Research

DOI: 10.18579/jpcrkc/2009/8/1/79536

Year: 2009, Volume: 8, Issue: 1, Pages: 12-14

Original Article

Synthesis and Evaluation of New 2-(Substituted Phenyl)- 3-[5'-(2'-Oxo-2H-chromen-3'-yl)-1,3,4-Oxadiazol-2-yl]-1, 3-Thiazolidin-4-Ones as Anticonvulsants

N. Siddiqui *, S. A. Khan , M. A. Bhat , W. Ahsan

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi-110062, India

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

A series of 2-(substituted phenyl)-3-[5'-(2"-oxo-2H-chromen-3'-yl)-1,3,4-oxadiazol-2-yl]-1,3-thiazolidin-4-ones 4-16 were synthesized in good yield and evaluated for their possible anticonvulsant and neurotoxic study. All the synthesized compounds were in good agreement with elemental and spectral data. Majority of the compounds were active in MES test. All the compounds were less neurotoxic than the standard drug phenytoin.