Journal of Pharmaceutical Research

Abstract

This study aimed to synthesize and characterize the different polymorphs of Trimipramine Maleate and Clomipramine Hydrochloride. Polymorphism is highly significant in pharmacies because it controls the physical and thermal properties of the compounds, and hence, drug effectiveness and stability. Polymorphs were synthesized using recrystallization with different solvent combinations, such as ethyl acetate, methanol, and acetonitrile. The polymorphs were analyzed by various methods: Fourier transform infrared (FTIR) spectroscopy for identification of functional groups, nuclear magnetic resonance (NMR) spectroscopy for the examination of molecular structure, differential scanning calorimetry (DSC) for examination of thermal behavior, and powder X-ray diffraction (PXRD) for determining crystal structure. All chemicals and reagents were obtained from authentic suppliers, and the synthesis was performed in research laboratories equipped with specialized facilities. Unique polymorphs of Trimipramine Maleate (Polymorphs I-V) and Clomipramine Hydrochloride (Polymorphs IA-VC) were detected and evaluated. FTIR analysis demonstrated variations in the spectral attributes for every polymorph, referring to structural differences. DSC indicated variations in the melting points as well as heat of fusion, whereas PXRD gave unique diffraction patterns, indicating different crystalline structures. Several polymorphs exhibited comparable thermal behavior, indicating closely linked molecular arrangements. The study results reveal information regarding the polymorphic structures of Trimipramine Maleate and Clomipramine Hydrochloride, which are significant for optimizing drug formulations.

Keywords: Polymorphs, Differential Scanning Calorimetry (DSC), Powder X-ray Diffraction (PXRD)