• P-ISSN 0973-7200 E-ISSN 2454-8405
  • Follow us

Journal of Pharmaceutical Research


Semecarpus Anacardium - A Wonderful Plant with Varied Medicinal Properties
  • VIEWS 688
  • PDF 267

Journal of Pharmaceutical Research

Year: 2016, Volume: 15, Issue: 4, Pages: 162-173

Original Article

Semecarpus Anacardium - A Wonderful Plant with Varied Medicinal Properties


Purpose: Traditional herbal plants have been used ever since human civilization started for treating various notable disorders. Semecarpus anacardium (SA) commonly called as Bhilwa is an ancient plant known as half physician for its ability to cure almost half of the known disorders and is available in form of various formulations in Ayurveda and siddha system of medicine. In the current review, complete pharmacological utility of the plant along with its geographical location, chemical constituents, its role in apoptosis and various other uses will be discussed.Approach: Information from the published research article available from Pubmed, google scholar and othersources were used in the preparation of this review article.Finding: SA has been reported to be a potential plant for the cure of diseases such as diabetes, myocardial infraction, asthma, rheumatoid arthritis, piles, cancer of liver, oesophagus, breast, mouth etc. It is a rich source of antioxidant having high free radical scavenging effect and is useful in treating heart diseases, CNS disorders and in cancer such as hepatocellular carcinoma, mammary carcinoma etc.Conclusion: SA can be used as an alternative therapy for various ailments however the precise mechanism underlying its various effects has not been determined fully. The phyto constituents present in this plant need to be isolated and can be developed into phyto-pharmaceuticals.


  • Balapure KM, Maheshwari JK, Tandon RK. Plants of Ramayana. Ancient science of life. 1987;(2): 76-84.
  • Gothoskar SV, Chitnis MP, Adwankar MK and Ranadive KJ. Antitumour activity of SAN-AB: an extract of marking nut, Semecarpus anacardium. Indian Journal of Experimental Biology. 1971; 9: 399.
  • Khare CP. Encyclopedia of Indian medicinal plants. 1982:419�21.
  • Sushma Y. Effect of Ethanolic Extract of Semecarpus Anacardium Fruit on Carrageenan Induced Paw Edema in Albino Rats. International Journal of Science and Research. 2013; 4(9): 652-655.
  • Ilanchezhian R, Roshy JC, Rabinarayan A, Vinay JS. Pharmacognostical and Physicochemical Analysis of Bhallataka (Semecarpus anacardium Linn.) � Fruit. Pharmacognosy Journal. 2011; 3(20): 9-16.
  • Rao NSP, Row L.R, Brown RT. Phenolic constituents of Semecarpus anacardium. Phytochemistry. 1973; 12(3): 671-681.
  • Raveedran N, Steven JM, Stanislaw FW, Magdelena R, Enrique E, Cheppail R. Isolation and characterization of an anticancer catechol compound from Semecarpus anacardium. Journal of ethnopharmacology. 2009; 122: 450-456.
  • Isharatulla KH, Ansari WH, Rahman W, Okigawa M, Kawano N. Biflavonoids from Seme carpusanacardium Linn. (Anacardiaceae). Indian Journal of Chemistry. 1977; 15B: 615-619.
  • Naidu DS. Constituents of the marking-nut: Semecarpus anacardium Linn. Journal of Indian Institute of Science. 1925; 8: 129-142.
  • Roberto RG, Long-Ze L, Geoffrey AC, Meda RK, Mul langi R, Bommineni MR, Gottumukkala KM, Achanta VNAR. Anacardoside f rom the seeds of Semecarpus anacardium. Phytochemistry. 1995; 39(2): 405-407.
  • Premalatha B. Semecarpus anacardium Linn. nuts-A boon in alternative medicine. Indian Journal of Experimental Biology. 2000; 38(12): 1177-1182.
  • Parag AP, Bhanu R. Multielement determination in methanolic soxhlet leaf extract of Semecarpus anacardium (Linn.f.) by ICP-AES technique. Asian journal of Pharmaceutical and Clinical Research. 2013; 6(3), 132-137.
  • Srinivasan A, Suresh BD, Senthilkumar N, Murugesan S. Physicochemical properties and phytochemical constituents ofSemecarpus anacardium L. seed oil. Advances in Applied Science Research. 2016; 7(3): 151-154.
  • Nadkarni AK. Indian Materia Medica. Popular Book Depot, Bombay. 1976; p. 322.
  • Kirtikar KR, Basu BD. Indian Medicinal Plants. Vol. 1, MS Bishen Singh�Mahendra Palsingh Publishers, Dehradun, India; 1975, 667.
  • Senthilvel G, Arul A, Sunil KN. Phytochemical Standardization of Serankottai nei (a Siddha drug from milk extract of Semecarpus Anacardium nuts) and its in-vitro antitubercular activity against H37Rv strain. International Journal of Pharmacology and Clinical Sciences. 2016; 5(1): 17-24.
  • Mythilypriya R, Shanthi P, Sachdanandam P. Analgesic, antipyretic and Ulcerogenic properties of an indigenous formulationKalpaamruthaa. Phytother Res. 2007; 21(6): 574-578.
  • Naveen K, Ganesh BB, Laxmikoteswramma K, Malla RR. Antioxidant, Cytoprotective and Anti-inflammatory activities of stem bark extract of Semecarpus anacardium. Asian Journal of Pharmaceutical and Clinical Research. 2013; 6(1): 213-219.
  • Atish KS, Nisha N, Sahanaa S, Rajan SS, Pulok KM. In Vitro Antioxidant Potential of Semecarpus anacardium L. Pharmacologyonline. 2008; 3: 327-335.
  • Ramprasath VR, Shanthi P, Sachdanandam P. Anti-inflammatory Effect of Semecarpus anacardium LINN. Nut Extract in Acute and Chronic Inflammatory Conditions. Biological and Pharmaceutical Bulletin. 2004; 27(12): 2028-2031.
  • Vijayalakshmi T, Muthulakshmi V, Sachdanandam P. Effect of milk extract of Semecarpus anacardium nuts on glycohydrolases and lysosomal stability in adjuvant arthritis in rats. Journal of Ethnopharmacology.1997; 58: 1-8.
  • Nada R, Datta U, Deodhar SD, Sehgal S. Neutrophil functions in Rheumatoid Arthritis. Indian Journal Pathology Microbiology. 1999; 42: 283-289.
  • Anderson, A.J. Lysosomal enzymes activity in rats with adjuvant induced arthritis. Annals of Rheumatism Disease.1986; 29: 307-313.
  • Zabin KB, Siddanagouda RS, Praveen GB. Phytochemical Screening and Evaluation of Antimicrobial Activity of Semecarpus anacardium Nuts. International Journal of Pharmacology and Pharmaceutical Technology. 2012; 1(2): 2277 � 3436.
  • Parag AP, Bhanu R. Assessment of Semecarpus anacardium (Linn.F.) leaf methanolic extract for their antibacterial, antifungal and antioxidant activity. International Journal of pharmacy and pharmaceutical sciences. 2013; 5(1): 170-174.
  • Kanika S, Sunil DS, Pooja M, Maheep B. Fungiststic activity of Semecarpus anacardium Linn. f nut extract. Indian journal of experimental biology. 2002; 40: 314-318.
  • Farooq SM, Alla TR, Rao NV, Prasad K, Shalam K, Satyanarayana S. A study on CNS effect of nut milk extract of Semicarpus anacardium. Pharmacologyonline. 2007; 1: 49�63.
  • Premalatha, B. and Sachdanandam, P. 1998. Immunomodulatory activity of Semecarpus anacardium Linn. nut milk extract in aflatoxin B1 induced hepatocellular Carcinoma in rats. Pharmacy and Pharmacology Communications. 1998; 4: 507-510.
  • Shukla, SD, Jain S, Sharma K, Bhatnagar M. Stress induced neuron degeneration and protective effects of Semecarpus anacardium Linn. and Withania somnifera Dunn. in hippocampus of albino rats: An ultrastructural study. Indian Journal of Experimental Biology. 2000;38(10):1007-13.
  • Bose BC, Mathur VS, Vijavargiya R. Study of chemical and pharmacological properties of Semecarpus anacardium Linn. Indian Journal of Medical Research. 1967; 55(2): 155-160.
  • Latha R, Shanthi P, Sachdanandam P, Kalpaamruthaa. Ameliorates Mitochondrial and Metabolic Alterations in Diabetes Mellitus Induced Cardiovascular Damage. Journal of Dietary Supplements. 2014; 11(4): 305-319.
  • Asdaq SMB, Chakraborty M. Myocardial Potency of Semecarpus anacardium nut extract against Isoproterenol induced Myocardial Damage in rats. International Journal of Pharmaceutical Sciences Review and Research. 2010; 2(2): 10-13.
  • Tripathi YB, Pandey RS. Semecarpus anacardium L, nuts inhibit lipopolysaccharide induced NO production in rat macrophages along with its hypolipidemic property. Indian Journal of Experimental Biology. 2004; 42(4): 432-436.
  • Haseena BHK, Kaladevi SV, Shanthi P, Sachdanandam P. Anti-diabetic effect of Semecarpus anacardium Linn nut milk extract in a high fat diet STZ-induced type 2 diabetic rat model. Comparative Clinical Pathology. 2012; 21(6): 1395-1400.
  • Anil KG, Bindal MC, Santosh KG, Dhirendra PV. Aphrodisiac activity of Semecarpus anacardium nut. International research journal of pharmacy. 2013; 4(4): 202-204.
  • Narayan JP, John MS, Ghosh PK, Singh JN, Jha OP, Jha IS. Screening of some medicinal plants for spermatostatic and spermicidal properties. Proceedings of symposium on phyto-chemistry and Botanical Classification CBS publishers and Distributors Pvt. Ltd. Delhi, India; 1985, 211-216.
  • Mallick N, Washim K, Mhaveer S, Zeeshan NM, Mohammad K, Sayeed A, Syed AH. In vitro anticancer potential of Semecarpus anacardium Linn. Symposium. 2016;7(1):55-58.
  • Premalatha B, Muthulakshmi V, Sachdanandam P. Anticancer potency of the milk extract of Semecarpus anacardium Linn. nuts against aflatoxin B mediated 1 hepatocellular carcinoma bearing wistar rats with reference to tumour marker enzymes. Phytotherapy Research. 1999; 13: 183�187.
  • Premalatha B, Sachdanandam P. Potency of Semecarpus anacardium Linn. nut milk extract against Aflatoxin B1-Induced Hepatocarcinogenesis: Reflection on Microsomal Biotransformation Enzymes. Pharmacological Research. 2000; 42(2): 161-166.
  • Premalatha B, Sachdanandam P. Stabilization of lysosomal membrane and cell membrane glycoprotein profile by Semecarpus anacardium linn. nut milk extract in experimental hepatocellular carcinoma. Phytotherapy Research. 2000; 14(5): 352-355.
  • Premalatha B, Sachdanandam P. Regulation of mineral status by Semecarpus anacardium Linn. nut milk extract in Aflatoxin B1-induced Hepatocellular Carcinoma. Journal of clinical biochemistry and nutrition. 1998; 25(2): 63-70.
  • Jemal A, Siegel R, Ward E, et al. Cancer statistics. Cancer J Clin. 2008; 58(2):71-96.
  • Panneerselvam M, Shanthi P, Sachdanandam P. Apoptotic Effect of Semecarpus anacardium Nut Extract on T47D Breast Cancer Cell Line. Cell Biology International. 2007; 31(10): 1198-1206.
  • Haseena BHK, Sachidanandam TP, Shanthi P. Apoptotic and cytotoxic effect of Semecarpus anacardium Linn nut milk extract on MCF-7 breast cancer cells. Comparative Clinical Pathology. 2015; 24(6): 1439-1444.
  • Arathi G, Sachidanandam P. Therapeutic effect of Semecarpus anacardium Linn. nut milk extract on carbohydrate metabolizing and mitochondrial TCA cycle and respiratory chain enzymes in mammary carcinoma rats. Journal of Pharmacy and Pharmacology. 2003; 55(9): 1283-1290.
  • Khan HB, Vani S, Palanivelu S, Panchanadham S. Erythrocyte Proto-porphyrin Fluorescence as a Biomarker to Monitor the Ant icancer Effect of Semecarpus anacardium in DMBA Induced Mammary Carcinoma Rat Model. Journal of Fluorescence. 2015; 25(4): 907-915.
  • Ramprasath VR, Shanthi P, Sachdanandam P. Evaluation of antioxidant effect of Semecarpus anacardium Linn. nut extract on the components of immune system in adjuvant arthritis. Vascular Pharmacol. 2005; 42: 179-186.
  • Sugapriya D, Shanthi P, Sachdanandam P. Restoration of energy metabolism in leukemic mice treated by a siddha drug Semecarpus anacardium Linn. nut milk extract. Chem Biol Interact. 2008; 173:43-58.
  • Sugapriya D, Ravindran J, Sachdanandam P, Shanthi P. Induction of Mitochondrionmediated Apoptosis by Semecarpus anacardium in the BCR-ABL+ 12B1 Leukemia Cell Line: Possible Mechanism of Therapeutic Action In Vivo. J Exp Clin Med. 2012; 4(1): 30-38.
  • llanchezhian R, Roshy JC, Acharya R. Urushiol-induced contact dermatitis caused during Shodhana (purificatory measures) of Bhallataka (Semecarpus anacardium Linn.) fruit. Ayu. 2012; 33(2): 270�273.
  • Kailash B, Rajesh K, Ashish S, Zainab HS, Ravindra K. Allergic Contact Dermatitis by Semecarpus Anacardium for Evil Eye: A prospective study from Central India. Indian Journal of Basic and Applied Medical Research. 2014; 3(3): 122-127.
  • Choudhari CV, Deshmukh PB. Effect of Semecarpus anacardium extract on physiology of brain in albino rat. Indian J. Innovations Dev. 2012; 1(1): 1-8.


Subscribe now for latest articles and news.