D. Shashank , S. V. Rajendra *, Anamika Mistry
- Department of Pharmacology,12/1, Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram Post, Varthur (H), Bangalore-560035, India
Abstract
Purpose: Herbal drugs are traditionally used in various parts of the world to cure a number of ailments. Celastrus paniculatus Willd is one such herbal plant which has been employed extensively in the treatment of several health conditions in traditional system of medicine. The current review is an effort to summarize the information based on evidence regarding the botanical aspects, phytoconstituents, traditional uses and pharmacological actions of Celastrus paniculatus.Findings: The leaves have healing effect on injuries while the seeds show significant action on the Central nervous system. The studies on laboratory animals demonstrated various pharmacological actions showing excellent activities on the brain.Conclusion: Celastrus paniculatus is a versatile plant, as all its plant parts possess the potential to treat several diseases due to the presence of various phytoconstituents. However these constituents have to be further isolated and characterized to check its activity on other common pharmacological disorders.
References
- Misra RC, Kumar S, Pani DR, Bhandari DC. Empirical tribal claims and correlation with bioactive compounds: A study on Celastrus paniculata Willd., a vulnerable medicinal plant of Odisha. Indian Journal of Traditional Knowledge 2012;11(4):615-22.
- Sujana KA, Joseph J. Ethnomedicinal uses of Celastrus paniculatus Willd. known to four tribal communities of Wayanad district of Kerala, India. International Journal of Research in Ayurveda & Pharmacy 2012;3(4):573-5.
- Athira K, Sajeev CR, Saroj KV, Sooraj NP, SunilKKN, Jaishanker R. Mapping traditional knowledge associated with Celastrus paniculatus in India using Geographical Information System (GIS). Journal of Ayurveda Medical Sciences 2016;1(2):55-62.
- Bhanumathy M, Chandrasekar SB, Chandur U, Somasundaram T. Phyto-pharmacology of Celastrus paniculatus: an Overview. International Journal of Pharmaceutical Sciences and Drug Research 2010;2(3):176-181.
- Katekhaye S, Duggal SA, Singh AP. An inside preview of nutritional and pharmacological profile of Celastrus paniculatus. Int J Recent Adv Pharm Res. 2011;1:19-24.
- Ahmad F, Khan RA, Rasheed S. Preliminary screening of methanolic extracts of Celastrus paniculatus and Tecomella undulata for analgesic and anti-inflammatory activities. Journal of ethnopharmacology. 1994;42(3):193-198.
- Sengupta A, Bhargava HN. Chemical investigation of the seed fat of Celastrus paniculatus. Journal of the Science of Food and Agriculture 1970;21(12):628-631.
- Basu NK, Pabrai PR. A chemical investigation of celastrus paniculata willd. Journal of Pharmaceutical Sciences 1946;35(9):272-273.
- Lu Y, Yang S, Zou Z, Luo X, Chen H, Xu L. Evoninoate sesquiterpene alkaloids from the stem of Celastrus paniculatus. Heterocycles. 2006;68(6):1241-1247.
- Patel DK, Amin KS, Nanavati DD. Chemistry and pharmacology of Celastrus paniculatus Willd. Indian drugs.1995;32(12):566-573.
- Pavanandt K, Webster HK, Yongvanitchit K, Kunanake A, Dechatiwongse T, Nutakul W, Bansiddhi J. Schizontocidal activity of Celastrus paniculatus Willd. against Plasmodium falciparum in vitro. Phytotherapy Research. 1989;3(4):136-139.
- Tu YQ, Wu TX, Li ZZ, Zhen T, Chen YZ. Sesquiterpene polyol esters from Celastrus paniculatus. Journal of Natural Products. 1991;54(5):1383-1386.
- SangH, WangH, TuY. New?- dihydroagarofuran sesquiterpenoids from Celastrus paniculatus. Mag Reson Chem. 2005;29(7):650-655.
- Arora N, Rai SP. Celastrus paniculatus, an endangered Indian medicinal plant with miraculous cognitive and other therapeutic properties: an overview. Int J Pharm Bio Sci. 2012;3(3):290-303.
- Yoganarasimhan SN. Medicinal plants of India. Volume 2. Tamil Nadu. Bangalore: The Author i.2000.
- Gamlath CB, Gunatilaka AL, Tezuka Y, Kikuchi T, Balasubramaniam S. Quinone-methide, phenolic and related triterpenoids of plants of Celastraceae: further evidence for the structure of Celastranhydride. Phytochemistry 1990;29(10):3189-3192.
- Vaidyaratnam PV. Indian medicinal plants: a compendium of 500 species. Orient Longman Ltd., Madras 1994;4:59-64.
- MohsenY DR. Ethno botanical study and traditional uses of Celastrus paniculatus. internationaljournal of innovative science 2015;2(11):139-143.
- Singh H, Krishna G, Baske PK. Plants used in the treatment of joint diseases (rheumatism, arthritis, gout and lumbago) in Mayurbhanj district of Odisha, India. Report and opinion 2010;2(9):22-26.
- Gattu M, Boss KL, Terry AV, Buccafusco JJ. Reversal of scopolamine-induced deficits in navigational memory performance by the seed oil of Celastrus paniculatus. Pharmacology Biochemistry and Behavior 1997;57(4):793-799.
- Lekha G, Kumar BP, Rao SN, Arockiasamy I, Mohan K. Cognitive enhancement and Neuroprotective effect of Celastrus paniculatus Willd. seed oil (Jyothismati oil) on male Wistar rats. Journal of Pharmaceutical Science and Technology 2010;2(2):130-138.
- Wakabayashi N, Wu WJ, Waters RM, Redfern RE, Mills Jr GD, DeMilo AB, Lusby WR, Andrzejewski D. Celangulin: a non alkaloidal insect antifeedant from Chinese bittersweet, Celastrus angulatus. Journal of Natural Products 1988;51(3):537-542.
- Chen PD, Liang JY. Progress of studies on constituents & activities of genus Celastrus. Strait pharmaceutical journal. 1999;11(3).
- Gattu M, Pauly JR, Boss KL, Summers JB, Buccafusco JJ. Cognitive impairment in spontaneously hypertensive rats: role of central nicotinic receptors. I. Brain research 1997;771(1):89-103.
- Russo A, Izzo AA, Cardile V, Borrelli F, Vanella A. Indian medicinal plants as antiradicals and DNA cleavage protectors. Phytomedicine 2001;8(2):125132.
- Kulkarni YA, Agarwal S, Garud MS. Effect of Jyotishmati (Celastrus paniculatus) seeds in animal models of pain and inflammation. Journal of Ayurveda and integrative medicine 2015;6(2):82-88.
- Patil RH, Prakash K, Maheshwari VL. Hypolipidemic effect of Celastrus paniculatus in experimentally induced hypercholesterolemic wistar rats. Indian Journal of Clinical Biochemistry 2010 1;25(4):405-410.
- Gatinode BB, Raiker KP, Shroff FN, Patel JR. Pharmacological studies with malkanguni, an indigenous tranquilizing drug (preliminary report). Current Practice. 1957;1:619-21.
- Kothavade PS, Bulani VD, Deshpande PS, Chowdhury AS, Juvekar AR. The petroleum ether fraction of Celastrus paniculatus Willd. seeds demonstrates anti-arthritic effect in adjuvant-induced arthritis in rats. Journal of Traditional Chinese Medical Sciences 2015 ;2(3):183-193.
- Bidwai PP, Wangoo D, Bhullar N. Antispermatogenic action of Celastrus paniculatus seed extract in the rat with reversible changes in the liver. Journal of ethnopharmacology 1990;28(3):293-303.
- Harish BG, Krishna V, Kumar HS, Ahamed BK, Sharath R, Swamy HK. Wound healing activity and docking of glycogen-synthase-kinase-3-?-protein with isolated triterpenoid lupeol in rats. Phytomedicine 2008 ;15(9):763-767.
- Patel RP, Trivedi BM. The in vitro antibacterial activity of some medicinal oils. The Indian journal of medical research 1962 ;50:218-222.
- Pandya KK, Patel RB, Chakravarthy BK. Antibacterial activity of some Indian medicinal plants. Indian Drugs 1990 ; 27: 415- 4117.
- Vonshak A, Barazani O, Sathiyamoorthy P, Shalev R, Vardy D, Golan-Goldhirsh A. Screening South Indian medicinal plants for antifungal activity against cutaneous pathogens. Phytotherapy Research. 2003;17(9):1123-1125.
- Palle S, Kanakalatha A, Kavitha CN. Gastroprotective and Antiulcer Effects of Celastrus paniculatus Seed Oil Against Several Gastric Ulcer Models in Rats. Journal of Dietary Supplements. 2017 :1-3.
- Badrul A, Ekramul H. Anti-alzheimer and antioxidant activity of Celastrus paniculatus seed. Iranian Journal of Pharmaceutical Sciences 2011 ;7(1):49-56.
