V. Niraimathi *, C. Vamsadhara , Lata Sriram
- Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India
Abstract
2-hetero substituted-4-quinazolone derivatives attract a wide spread interest due to the diverse biological activities. Six novel 2-heterosubstituted quinazolones were synthesized and the structures were assigned on the basis of spectral data. These compounds were screened for their antimicrobial activity. The recorded zone of inhibition showed significant broad spectrum antibacterial activity when compared with standard ciprofloxacin. Antifungal screening indicated that all the synthesized moieties had inhibitory effect against the tested pathogenic fungi.
