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Journal of Pharmaceutical Research

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Design and Evaluation of Transdermal Patches of Nicorandil
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Journal of Pharmaceutical Research

DOI: 10.18579/jopcr/v17.4.shahla

Year: 2018, Volume: 17, Issue: 4, Pages: 27-33

Original Article

Design and Evaluation of Transdermal Patches of Nicorandil

Shahla Hosseini1, Preethi Sudheer1,∗

1Department of Pharmaceutics, Krupanidhi College of Pharmacy, Carmelaram, Varthur Hobli, Bengaluru, Karnataka, India

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objectives: The purpose of this study was to develop a transdermal patch containing the drug nicorandil with different ratios of Eudragit RL 100 polymeric by solvent casting method. Methods: The prepared patches were evaluated for physicochemical characterization, thickness uniformity, mass uniformity, drug content uniformity, folding endurance, moisture loss, FTIR, SEM, in vitro release, ex vivo permeation, and stability studies. Findings: The results of the studies suggest that formulated transdermal patches with good physical properties and drug content were obtained by the solvent casting method. Surface morphological studies indicated uniform distribution of drugs in the polymeric patch formulation. The in vitro diffusion study suggested that drug release was controlled by all six formulations in comparison with the pure drug. The cumulative release of the drug in phosphate buffer pH 6.8 from formulations (F1-F6) ranged between 89.55±0.62- 78.52±0.63% in a 12-hour study. Ex vivo results showed a good correlation with the in vitro study results. About 89.55±0.62% of the drug from (F4=drug: polymer 1:4) permeated through the rat abdominal skin sample over a period of 12 h. Novelty: Transdermal patches could be a good alternative for controlled drug therapy with nicorandil.

Keywords: Nicorandil, Eudragit, Transdermal patches, Controlled release, In vitro release

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Copyright

© 2018 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) 

  • 25 September 2024

Year: 2018, Volume: 17, Issue: 4


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