Journal of Pharmaceutical Research

Abstract

Background: Dysphagia is a common issue across all age groups, particularly with solid dosage forms. The development of fast-dissolving oral dosage forms has gained significant attention due to their convenience and improved patient compliance. This study focuses on the formulation and evaluation of fast-dissolving oral dosage forms containing dietary supplements, aiming to enhance the bioavailability and efficacy of these supplements. Methods: Tablets were designed using the direct compression method with an effervescent mixture of sodium bicarbonate, citric acid, and tartaric acid, as well as super disintegrants such as Crospovidone and croscarmellose sodium, both individually and in combination. Veegum-F (magnesium aluminium silicate) was utilised for masking the taste of the vitamins. The prepared tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio, and in vitro dispersion time. Findings: By incorporating taste-masking agents and an effervescent mixture, the formulation ensures rapid disintegration and improved palatability. Formulation F5, which utilized the effervescent mixture and taste-masking agent, was identified as the optimal formulation based on its in vitro dispersion time (approximately 70-80 seconds), short-term stability (maintained at 40°C/75% RH for 3 months), and drug-excipient interaction results from IR spectroscopy. Stability studies of formulation F5 demonstrated no significant changes in drug content or in vitro dispersion time, confirming its effectiveness and reliability. Novelty: The potential use of fast-dissolving oral dosage forms in enhancing the delivery of dietary supplements, offers a practical solution for individuals seeking efficient and convenient supplementation.

Keywords: Croscarmellose sodium, Crospovidone, Fast dissolving tablets, Effervescent Mixture, Vitamin B Complex, Vitamin C