Mishra Debidani 1*, S. Ramakrishna 2, Nayak Bhabani Shankar 1, P. Ellaiah 1
- Department of Pharmacognosy, Faculty of Pharmacy, Jeypore College of Pharmacy, Rondapalli, Jeypore - 764002, Koraput, Odisha, India
- Department of Pharmacognosy, Faculty of Pharmacy, College of Pharmaceutical Sciences, Mohuda, Berhampur � 760002, Odisha, India
Abstract
Eupatorium odoratum Linn is found in the tribal area of Baipariguda (Dist: Koraput) and extensively used traditionally by the tribal people as anthelmintic, antibacterial, antifungal and wound healing agent. The present study is an attempt to preliminary investigation of phytochemical constituents and to explore the wound healing property of the ointments prepared from solvent extracts (Petroleum ether, ethanol and chloroform). The phytochemical studies indicated that the tests for alkaloids, tannins and phenolic compounds were positive while the tests for anthraquinone glycosides, proteins, amino acids and saponins were negative for all extracts. Other chemical tests exhibited varying results. The various doses of ointment extracts were evaluated for their wound healing activities on healthy Wistar rats by excision wound models. All extracts showed wound healing activity and activities are well compared with the standard drugs (neosporin and betadine). When the dose of the extract is increased, a gradual increase in wound healing activity was observed. Among all the extracts (ointments), ethanolic extract containing ointment showed better wound healing activity over the others and even in comparison to standard drugs.
