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Journal of Pharmaceutical Research

Article

Journal of Pharmaceutical Research

Year: 2023, Volume: 22, Issue: 3, Pages: 124-132

Review Article

A Review on Kidney Stones & A Patient Satisfaction Survey of an Ayurvedic Brand to Treat Kidney Stones

Abstract

Objective: Kidney stones or nephrolithiasis, is a common problem worldwide. About 12% of the Indian population is estimated to have kidney stones and out of which 50% may end up with loss of kidney functions. In the first part of this article the pathophysiology of kidney stone, its types, risk factors, signs, symptoms, diagnosis and therapy have been discussed. Furthermore, various therapeutic approaches for kidney stone management are also briefly renewed. Methods: The second part of this article discusses a herbal formulation Ren-Cit® successfully used to treat kidney stone, its usage, composition as well as the actions of each of its medicinal constituents. A survey of patients who used Ren-Cit® has been conducted. Finding: The analysis of this survey revealed that 98% of the patients were suffering from kidney stone. Out of these 78% of the patients had hypertension and diabetes. None of the participants observed any side effects from the usage of Ren-Cit®. A total of 76% patients got relief from kidney stone by using Ren-Cit®. Various types of kidney stones diagnosed in these patients had varied composition, viz.; calcium oxalate stone (52%), calcium phosphate stone (16%), uric acid stone (12%), struvite stone (12%) and cystine stone (8%). Novelty: Ren- Cit® ayurvedic formulation proved to be effective on a wide range and types of kidney Stones.

Keywords: Kidney Stone; Urolithiasis; Calcium Oxalate; Uric Acid Stone; Calcium Phosphate; Ren-Cit®

References

  1. Agarwal S, Gupta SJ, Saxena AK, Gupta NJ, Agarwal S. Urolithic property of Varuna (Crataeva nurvala): An experimental study. AYU (An International Quarterly Journal of Research in Ayurveda). 2010;31(3):361. Available from: https://doi.org/10.4103/0974-8520.77161
  2. Niroumand MC, Farzaei MH, Gholamreza A. Medicinal properties of Peganum harmala L. in traditional Iranian medicine and modern phytotherapy: A review. J Tradit Chin Med. 2015;35:30016–30025. Available from: https://doi.org/10.1016/s0254-6272(15)30016-9
  3. Verma P, Gauttam V, Kalia AN. Comparative pharmacognosy of pashanbhed. J Ayurveda Integr Med. 2014;5. Available from: https://doi.org/10.4103/0975-9476.131728
  4. García PH, Solarte P, España P. Pathophysiology associated with forming urinary stones. Urol. Colomb. 2016;25. Available from: https://doi.org/10.1016/j.uroco.2015.12.013
  5. Ferraro PM, Taylor EN, Eisner BH, Gambaro G, Rimm EB, Mukamal KJ, et al. History of Kidney Stones and the Risk of Coronary Heart Disease. JAMA. 2013;310(4):408. Available from: https://doi.org/10.1001/jama.2013.8780
  6. Nalini HS, Manickavasakam K, Thomas MW. Prevalence and risk factors of kidney stone. Glob J Res Anal. 2016;5(3):183–187. Available from: https://www.researchgate.net/publication/299543144_PREVALENCE_AND_RISK_FACTORS_OF_KIDNEY_STONE
  7. Khan SR, Pearle MS, Robertson WG, Gambaro G, Canales BK, Doizi S, et al. Kidney stones. Nature Reviews Disease Primers. 2016;2(1). Available from: https://doi.org/10.1038/nrdp.2016.8
  8. Kumar K, Abhishek A. Artificial Neural Networks for Diagnosis of Kidney Stones Disease. International Journal of Information Technology and Computer Science. 2012;4(7):20–25. Available from: https://www.mecs-press.org/ijitcs/ijitcs-v4-n7/IJITCS-V4-N7-3.pdf
  9. Matlaga BR, Schaeffer AJ, Novak TE, Trock BJ. Epidemiologic insights into pediatric kidney stone disease. Urological Research. 2010;38(6):453–457. Available from: https://doi.org/10.1007/s00240-010-0327-9
  10. Claudia DA, Ferraro PM, Cianchi C, Barsotti M, Gambaro G, Cupisti A. Which diet for calcium stone patients: a real-world approach to preventive care. Nutrients. 2019;11. Available from: https://doi.org/10.3390/nu11051182
  11. Cloutier J, Villa L, Traxer O, Daudon M. Kidney stone analysis: “Give me your stone, I will tell you who you are!”. World Journal of Urology. 2015;33(2):157–169. Available from: https://doi.org/10.1007/s00345-014-1444-9
  12. Khokhlenkova NV, Buryak MV, Povrozina OV, Kamina TV. Principles of the Urolithiasis Phytotherapy. Research Journal of Pharmacy and Technology. 2019;12(9):4559. Available from: https://doi.org/Principles of the Urolithiasis Phytotherapy
  13. Zeng J, Wang S, Zhong L, Huang Z, Zeng Y, Zheng D, et al. A Retrospective Study of Kidney Stone Recurrence in Adults. Journal of Clinical Medicine Research. 2019;11(3):208–212. Available from: https://doi.org/10.14740/jocmr3753
  14. Aggarwal R, Srivastava A, Jain SK, Sud R, Singh R. Renal Stones: A Clinical Review. EMJ Urology. 2017;5:98–103.
  15. Jung HD, Cho S, Lee JY. Update on the Effect of the Urinary Microbiome on Urolithiasis. Diagnostics. 2023;13(5):951. Available from: https://doi.org/10.3390/diagnostics13050951
  16. Hannan MA, Zahan MS, Sarker PP, Moni A, Ha H, Uddin MJ. Protective Effects of Black Cumin (Nigella sativa) and Its Bioactive Constituent, Thymoquinone against Kidney Injury: An Aspect on Pharmacological Insights. International Journal of Molecular Sciences. 2020;22(16):9078. Available from: https://doi.org/10.3390/ijms22169078
  17. Curhan GC, Willett WC, Rimm EB, Spiegelman D, Stampfer MJ. Prospective Study of Beverage Use and the Risk of Kidney Stones. American Journal of Epidemiology. 1996;143(3):240–247. Available from: https://doi.org/10.1093/oxfordjournals.aje.a008734
  18. Khan F, Haider MF, Singh MK, Sharma P, Kumar T, Neda EN. A comprehensive review on kidney stones, its diagnosis and treatment with allopathic and ayurvedic medicines. Urology & Nephrology Open Access Journal. 2019;7(4):69–74. Available from: https://doi.org/10.1093/oxfordjournals.aje.a008734
  19. Sari S, Baylan B, Sezer E, Cataroglu CK, Ozok HU, Ersoy H. Percutaneous Nephrolithotomy Performed on the Kidney Stone in a Patient With Ankylosing Spondylitis: A Case Study. Urology Case Reports. 2015;3(4):123–125. Available from: https://doi.org/10.1016/j.eucr.2015.04.003
  20. Tseng TY, Preminger GM. Kidney stones: flexible ureteroscopy. BMJ Clin Evid. 2003;p. 4632914. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4632914/
  21. Bourcier JEE, Gallard E, Redonnet JPP, Abillard M, Billaut Q, Fauque L, et al. Ultrasound at the patient’s bedside for the diagnosis and prognostication of a renal colic. The Ultrasound Journal. 2021;13(1). Available from: https://doi.org/10.1186/s13089-021-00246-2
  22. Shirfule AL, Racharla V, Qadri SSYH, Khandare AL. Exploring Antiurolithic Effects of Gokshuradi Polyherbal Ayurvedic Formulation in Ethylene-Glycol-Induced Urolithic Rats. Evidence-Based Complementary and Alternative Medicine. 2013;2013(9):1–9. Available from: https://doi.org/10.1155/2013/763720
  23. Borghi L, Schianchi T, Meschi T, Guerra A, Allegri F, Maggiore U, et al. Comparison of Two Diets for the Prevention of Recurrent Stones in Idiopathic Hypercalciuria. New England Journal of Medicine. 2002;346(2):77–84. Available from: https://doi.org/10.1056/NEJMoa010369
  24. Xu H, Zisman AL, Coe FL, Worcester EM. Kidney stones: an update on current pharmacological management and future directions. Expert Opinion on Pharmacotherapy. 2013;14(4):435–447. Available from: https://doi.org/10.1517/14656566.2013.775250

Copyright

© 2023 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/

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