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Journal of Pharmaceutical Research

Article

Journal of Pharmaceutical Research

Year: 2024, Volume: 23, Issue: 3, Pages: 129-140

Review Article

Understanding Silent Eruptions of Depression among Youngsters and Adolescents

Abstract

A calm insanity of any kind was included in the original broad definition of melancholia along with the present idea of affective illnesses, which today views mood as the primary disturbance, the term depression first appeared in the nineteenth century. A very complicated mental illness, major depressive disorder (MDD) is commonly referred to as depression. It is marked by a depressed mood, diminished interests, and disinterest in routine tasks, feelings of loneliness, impaired cognitive function, and vegetative symptoms like disturbed sleep or appetite and a lack of desire. Research illustrating the frequency of depression in kids and teens reveals that a sizable portion of kids in both age groups experience symptoms of despair. According to the analysis, there are no differences between the adult and child depression constructs in terms of mental classifications, and a comprehensive understanding of depression. Considering the child's developmental stage and cognitive and linguistic abilities, children with MDD share many of the same key characteristics as adults and adolescents. Research on the general population is the only source of information on many significant issues regarding depression in young people. Teens suffering from mental illnesses are a vulnerable population that requires more care. It takes equilibrium between feelings, ideas, and behavior to maintain mental health. An important source of morbidity and death in children and adolescents is depression disorders, which are frequent and repeated illnesses. Adult psychopathology has been linked to early trauma in the form of physical or sexual abuse experienced as a kid. Selective serotonin reuptake inhibitors (SSRIs) are commonly prescribed as the initial treatment for depression in children and adolescents. Fluoxetine offers the strongest safety and effectiveness data when compared to other antidepressants, especially when used in teenagers who are 12 years of age or older. Adolescents' self-reports of attachment anxiety and avoidance can be effectively addressed through Interpersonal Psychotherapy for Adolescents (IPT-A). This therapy appears particularly beneficial for those exhibiting high levels of avoidant attachment. The study highlights that attachment anxiety and avoidance are modifiable during adolescence and can be viable treatment targets. IPT-A has proven effective in treating attachment-related issues, with reductions in attachment anxiety and avoidance correlating with decreases in depressive symptoms. This supports the use of IPT-A for depressed adolescents struggling with attachment security, especially those with an avoidant attachment style who tend to shy away from intimacy.

Keywords

Depression, Adolescents, Youngsters, Child maltreatment, Suicide, Abuse, Fluoxetine

References

  1. Duval F, Lebowitz BD, Macher JP. Treatments in depressionDialogues in Clinical Neuroscience2006;8(2):191206. Available from: https://doi.org/10.31887/DCNS.2006.8.2/fduval
  2. Hu Y, Yiu V, Clark R. Etiology of Depression: Biological and Environmental Factors in the Development of DepressionJournal of Student Research2021;10(4):18. Available from: https://doi.org/10.47611/jsrhs.v10i4
  3. Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M, et al. Major depressive disorderNature Reviews Disease Primers2016;2. Available from: https://doi.org/10.1038/nrdp.2016.65
  4. Sarizadeh MS, Najafi M, Rezaei AM. The prediction of depression based on religious coping and the components of positive youth development in adolescentsMental Health, Religion & Culture2020;23(2):216228. Available from: https://doi.org/10.1080/13674676.2019.1710123
  5. Asarnow JR, Jaycox LH, Tompson MC. Depression in Youth: Psychosocial InterventionsJournal of Clinical Child & Adolescent Psychology2001;30(1):3347. Available from: https://doi.org/10.1207/S15374424JCCP3001_5
  6. Solomon DA, Keller MB, Leon AC, Mueller TI, Lavori PW, Shea MT, et al. Multiple Recurrences of Major Depressive DisorderAmerican Journal of Psychiatry2000;157(2):229233. Available from: https://doi.org/10.1176/appi.ajp.157.2.229
  7. Cui L, Li S, Wang S, Wu X, Liu Y, Yu W, et al. Major depressive disorder: hypothesis, mechanism, prevention and treatmentSignal Transduction and Targeted Therapy2024;9:132. Available from: https://doi.org/10.1038/s41392-024-01738-y
  8. Bernaras E, Jaureguizar J, Garaigordobil M. Child and adolescent depression: A review of theories, evaluation instruments, prevention programs, and treatmentsFrontiers in Psychology2019;10:124. Available from: https://doi.org/10.3389/fpsyg.2019.00543
  9. Garvik M, Idsoe T, Bru E. Motivation and Social Relations in School Following a CBT Course for Adolescents With Depressive Symptoms: An Effectiveness StudyScandinavian Journal of Educational Research2016;60(2):219239. Available from: https://doi.org/10.1080/00313831.2015.1017838
  10. Gladstone TRG, Beardslee WR. The Prevention of Depression in Children and Adolescents: A ReviewThe Canadian Journal of Psychiatry2009;54(4):212221. Available from: https://doi.org/10.1177/070674370905400402
  11. Bardone AM, Moffitt TE, Caspi A, Dickson N, Silva PA. Adult mental health and social outcomes of adolescent girls with depression and conduct disorderDevelopment and Psychopathology2009;8(4):811829. Available from: https://doi.org/10.1017/S0954579400007446
  12. Bardone AM, Moffitt TE, Caspi A, Dickson N, Stanton WR, Silva PA. Adult Physical Health Outcomes of Adolescent Girls With Conduct Disorder, Depression, and AnxietyJournal of the American Academy of Child & Adolescent Psychiatry1998;37(6):594601. Available from: https://doi.org/10.1097/00004583-199806000-00009
  13. Bouma EMC, Ormel J, Verhulst FC, Oldehinkel AJ. Stressful life events and depressive problems in early adolescent boys and girls: the influence of parental depression, temperament and family environmentJournal of Affective Disorders2008;105(1-3):185193. Available from: https://doi.org/10.1016/j.jad.2007.05.007
  14. Charles J, Fazeli M. Depression in childrenAustralian Family Physician2017;46(12):901907. Available from: https://pubmed.ncbi.nlm.nih.gov/29464226/
  15. Chorpita BF, Yim L, Moffitt C, Umemoto LA, Francis SE. Assessment of symptoms of DSM-IV anxiety and depression in children: a revised child anxiety and depression scaleBehaviour Research and Therapy2000;38(8):835855. Available from: https://doi.org/10.1016/S0005-7967(99)00130-8
  16. Garber J. Depression in Children and Adolescents: Linking Risk Research and PreventionAmerican Journal of Preventive Medicine2006;31(6, Supplement 1):104125. Available from: https://doi.org/10.1016/j.amepre.2006.07.007
  17. Graham P, Rutter M. Psychiatric Disorder in the Young Adolescent: A Follow-Up StudyJournal of the Royal Society of Medicine1973;66(12):12261229. Available from: https://pubmed.ncbi.nlm.nih.gov/4777055/
  18. Ryan ND, Puig-Antich J, Ambrosini P, Rabinovich H, Robinson D, Nelson B, et al. The Clinical Picture of Major Depression in Children and AdolescentsArchives Of General Psychiatry1987;44(10):854861. Available from: https://doi.org/10.1001/archpsyc.1987.01800220016003
  19. Carlson GA, Kashani JH. Phenomenology of major depression from childhood through adulthood: analysis of three studiesAmerican Journal of Psychiatry1988;145(10):12221225. Available from: https://doi.org/10.1176/ajp.145.10.1222
  20. Lefkowitz MM, Tesiny EP. Depression in children: Prevalence and correlatesJournal of Consulting and Clinical Psychology1985;53(5):647656. Available from: https://psycnet.apa.org/doi/10.1037/0022-006X.53.5.647
  21. Carlson G, Strober M. Affective Disorders in AdolescencePsychiatric Clinics of North America1979;2(3):511526. Available from: https://dx.doi.org/10.1016/s0193-953x(18)30994-8
  22. Mitchell J, McCauley E, Burke PM, Moss SJ. Phenomenology of Depression in Children and AdolescentsJournal of the American Academy of Child and Adolescent Psychiatry1988;27(1):1220. Available from: https://doi.org/10.1097/00004583-198801000-00004
  23. Baker M, Dorzab J, Winokur G, Cadoret RJ. Depressive disease: Classification and clinical characteristicsComprehensive Psychiatry1971;12(4):354365. Available from: https://doi.org/10.1016/0010-440x(71)90073-3
  24. Burke P, Delbeccaro M, Mccauley E, Clark C. Hallucinations in Children: A Follow‐up StudyJournal of the American Academy of Child Psychiatry1985;24(1):7175. Available from: https://psycnet.apa.org/doi/10.1016/S0002-7138(09)60412-X
  25. Kovacs M, Yaroslavsky I. Practitioner review: Dysphoria and its regulation in child and adolescent depressionJournal of Child Psychology and Psychiatry2014;55(7):741757. Available from: https://doi.org/10.1111/jcpp.12172
  26. Adrian M, Zeman J, Veits G. Methodological implications of the affect revolution: A 35-year review of emotion regulation assessment in childrenJournal of Experimental Child Psychology2011;110(2):171197. Available from: https://doi.org/10.1016/j.jecp.2011.03.009
  27. Purper-Ouakil D, Michel G, Mouren-Siméoni MC. Vulnerability to depression in children and adolescents: update and perspectivesEncephale2002;28(3 Pt 1):234240. Available from: https://pubmed.ncbi.nlm.nih.gov/12091784/
  28. Merikangas KR, Nakamura EF, Kessler RC. Epidemiology of mental disorders in children and adolescentsDialogues in Clinical Neuroscience2009;11(1):720. Available from: https://doi.org/10.31887/DCNS.2009.11.1/krmerikangas
  29. Stellman SD. Epidemiology, L. Gordis, Fourth ed, 2009, SaundersPreventive Medicine2010;50(5-6):310311. Available from: https://doi.org/10.1016/j.ypmed.2010.02.010
  30. Kessler RC, Bromet EJ. The epidemiology of depression across culturesAnnual Review of Public Health 2013;34:119138. Available from: https://doi.org/10.1146/annurev-publhealth-031912-114409
  31. Stein DJ, Lim C, Roest AM, Jonge PD, Aguilar-Gaxiola S, Al-Hamzawi A, et al. The cross-national epidemiology of social anxiety disorder: Data from the World Mental Health Survey InitiativeBMC Medicine2017;15:121. Available from: https://doi.org/10.1186/s12916-017-0889-2
  32. Kessler RC. The costs of depressionPsychiatric Clinics of North America2012;35(1):114. Available from: https://doi.org/10.1016/j.psc.2011.11.005
  33. Higgs J. The Depressed Child and AdolescentArchives of Disease in Childhood1997;76:175. Available from: https://doi.org/10.1136/adc.76.2.175c
  34. Triana R, Keliat BA, Wardani IY, Sulistiowati N, Veronika MA. Understanding the protective factors [self-esteem, family relationships, social support] and adolescents’ mental health in JakartaEnfermería Clínica2019;29(Supplement 2 ):629633. Available from: https://doi.org/10.1016/j.enfcli.2019.04.096
  35. Olsson G. Adolescent DepressionUpsala Journal of Medical Sciences1998;103(2):77146. Available from: https://doi.org/10.3109/03009739809178946
  36. Adams DM, Overholser JC, Spirito A. Stressful Life Events Associated with Adolescent Suicide AttemptsThe Canadian Journal of Psychiatry1994;39(1):4348. Available from: https://doi.org/10.1177/070674379403900109
  37. Pelham WE, Gnagy EM, Greenslade KE, Milich R. Teacher Ratings of DSM-III-R Symptoms for the Disruptive Behavior DisordersJournal of the American Academy of Child and Adolescent Psychiatry 1992;31(2):210218. Available from: https://doi.org/10.1097/00004583-199203000-00006
  38. Asarnow JR, Goldstein MJ, Carlson GA, Perdue S, Bates S, Keller J. Childhood-onset depressive disorders: A follow-up study of rates of rehospitalization and out-of-home placement among child psychiatric inpatientsJournal of Affective Disorders1988;15(3):245253. Available from: https://doi.org/10.1016/0165-0327(88)90022-5
  39. Fergusson DM, Horwood LJ, Lynskey MT. Prevalence and Comorbidity of DSM-III-R Diagnoses in a Birth Cohort of 15 Year OldsJournal of the American Academy of Child and Adolescent Psychiatry1993;32(6):11271134. Available from: https://doi.org/10.1097/00004583-199311000-00004
  40. Akiskal HS, King D, Rosenthal TL, Robinson D, Scott-Strauss A. Chronic depressions: Part 1. Clinical and familial characteristics in 137 probandsJournal of Affective Disorders1981;3(3):297315. Available from: https://doi.org/10.1016/0165-0327(81)90031-8
  41. Demir T, Karacetin G, Demir DE, Uysal O. Epidemiology of depression in an urban population of Turkish children and adolescentsJournal of Affective Disorders2011;134(1-3):168176. Available from: https://doi.org/10.1016/j.jad.2011.05.041
  42. Kim-Cohen J, Caspi A, Moffitt TE, Harrington H, Milne BJ, Poulton R. Prior juvenile diagnoses in adults with mental disorder: developmental follow-back of a prospective-longitudinal cohortArchives Of General Psychiatry2003;60(7):709717. Available from: https://doi.org/10.1001/archpsyc.60.7.709
  43. Wittchen HU, Nelson CB, Lachner G. Prevalence of mental disorders and psychosocial impairments in adolescents and young adultsPsychological Medicine1998;28(1):109126. Available from: https://doi.org/10.1017/s0033291797005928
  44. Costello EJ, Mustillo S, Erkanli A, Keeler G, Angold A. Prevalence and Development of Psychiatric Disorders in Childhood and AdolescenceArchives Of General Psychiatry2003;60(8):837844. Available from: https://doi.org/10.1001/archpsyc.60.8.837
  45. Angold A, Erkanli A, Farmer E, Fairbank JA, Burns BJ, Keeler G, et al. Psychiatric disorder, impairment, and service use in rural African American and white youthArchives Of General Psychiatry2002;59(10):893901. Available from: https://doi.org/10.1001/archpsyc.59.10.893
  46. González-Tejera G, Canino G, Ramírez R, Chávez L, Shrout P, Bird H, et al. Examining minor and major depression in adolescentsJournal of Child Psychology and Psychiatry2005;46(8):888899. Available from: https://doi.org/10.1111/j.1469-7610.2005.00370.x
  47. Lewinsohn PM, Shankman SA, Gau JM, Klein DN. The prevalence and co-morbidity of subthreshold psychiatric conditionsPsychological Medicine2004;34(4):613622. Available from: https://doi.org/10.1017/s0033291703001466
  48. Earls F. Epidemiology and child psychiatry: Future prospectsComprehensive Psychiatry1982;23(1):7584. Available from: https://dx.doi.org/10.1016/0010-440x(82)90011-6
  49. Werner EE, Smith RS. A Report from the Kauai Longitudinal StudyJournal of the American Academy of Child Psychiatry1979;18(2):292306. Available from: https://dx.doi.org/10.1016/s0002-7138(09)61044-x
  50. Graham PJ. Epidemiologic Perspectives On Maladaptation In Children: Neurological, Familial, and Social FactorsJournal of the American Academy of Child Psychiatry1978;17(2):197208. Available from: https://doi.org/10.1016/S0002-7138(10)60086-6
  51. Kessler RC, Berglund P, Demler O, RJ, DK, Merikangas KR, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey ReplicationJAMA2003;289(23):30953105. Available from: https://doi.org/10.1001/jama.289.23.3095
  52. Saveanu RV, Nemeroff CB. Etiology of Depression: Genetic and Environmental FactorsPsychiatric Clinics of North America2012;35(1):5171. Available from: https://dx.doi.org/10.1016/j.psc.2011.12.001
  53. Evans DL, Charney DS, Lewis L, Golden RN, Gorman JM, Krishnan KRR, et al. Mood Disorders in the Medically Ill: Scientific Review and RecommendationsBiological Psychiatry2005;58(3):175189. Available from: https://dx.doi.org/10.1016/j.biopsych.2005.05.001
  54. Langlieb AM, Jr JRD. Etiology of Depression and Implications on Work EnvironmentJournal of Occupational & Environmental Medicine2008;50(4):391395. Available from: https://dx.doi.org/10.1097/jom.0b013e31816fca08
  55. Berger AM, Knutson JF, Mehm JG, Perkins KA. The self-report of punitive childhood experiences of young adults and adolescentsChild Abuse & Neglect1988;12(2):251262. Available from: https://dx.doi.org/10.1016/0145-2134(88)90033-6
  56. Wekerle C, Leung E, Wall AM, Macmillan H, Boyle M, Trocme N. The contribution of childhood emotional abuse to teen dating violence among child protective services-involved youthChild Abuse & Neglect2009;33(1):4558. Available from: https://doi.org/10.1016/j.chiabu.2008.12.006
  57. Mannarino AP, Cohen JA. A clinical-demographic study of sexually abused childrenChild Abuse & Neglect1986;10(1):1723. Available from: https://doi.org/10.1016/0145-2134(86)90027-X
  58. Resnick MD, Blum RW, Harris LM, Geer L, Hutton L, Rosenwinkel K. Correlates of sexual abuse among adolescents: A population based studyJournal of Adolescent Health Care1989;10(3):248. Available from: https://doi.org/10.1016/0197-0070(89)90242-8
  59. Jakubczyk A, Klimkiewicz A, Krasowska A, Kopera M, Sławińska-Ceran A, Brower KJ. History of sexual abuse and suicide attempts in alcohol-dependent patientsChild Abuse & Neglect2014;38(9):15601568. Available from: https://doi.org/10.1016%2Fj.chiabu.2014.06.010
  60. Bohnert ASB, Roeder KM, Ilgen MA. Suicide attempts and overdoses among adults entering addictions treatment: Comparing correlates in a U.S. national studyDrug and Alcohol Dependence2011;119(1-2):106112. Available from: https://doi.org/10.1016/j.drugalcdep.2011.05.032
  61. Brown GR, McBride L, Bauer MS, Williford WO. Impact of childhood abuse on the course of bipolar disorder: A replication study in U.S. veteransJournal of Affective Disorders2005;89(1-3):5767. Available from: https://doi.org/10.1016/j.jad.2005.06.012
  62. Carlin AS, Kemper K, Ward NG, Sowell H, Gustafson B, Stevens N. The effect of differences in objective and subjective definitions of childhood physical abuse on estimates of its incidence and relationship to psychopChild Abuse & Neglect1994;18(5):393399. Available from: https://doi.org/10.1016/0145-2134(94)90024-8
  63. Rellini A, Meston C. Sexual Function and Satisfaction in Adults Based on the Definition of Child Sexual AbuseThe Journal of Sexual Medicine2007;4(5):13121321. Available from: https://doi.org/10.1111/j.1743-6109.2007.00573.x
  64. Castellini G, Sauro CL, Lelli L, Godini L, Vignozzi L, Rellini AH, et al. Childhood Sexual Abuse Moderates the Relationship Between Sexual Functioning and Eating Disorder Psychopathology in Anorexia Nervosa and Bulimia Nervosa: A 1-Year Follow-Up StudyThe Journal of Sexual Medicine2013;10(9):21902200. Available from: https://doi.org/10.1111/jsm.12232
  65. Hsu LKG. Outcome of anorexia nervosa. A review of the literature (1954 to 1978) Archives of General Psychiatry1980;37(9):10411046. Available from: https://doi.org/10.1001/archpsyc.1980.01780220079009
  66. Riggs S, Alario AJ, McHorney C. Health risk behaviors and attempted suicide in adolescents who report prior maltreatmentJournal of Pediatrics1990;116(5):815821. Available from: https://doi.org/10.1016/s0022-3476(05)82679-4
  67. Silbert MH, Pines AM. Sexual child abuse as an antecedent to prostitutionChild Abuse & Neglect1981;5(4):407411. Available from: https://doi.org/10.1016/0145-2134(81)90050-8
  68. Dadds MR, Barrett PM. Family Processes in Child and Adolescent Anxiety and DepressionBehaviour Change2014;13(4, Special Issue-Part II):231239. Available from: https://doi.org/10.1017/S0813483900004836
  69. Carballo JJ, Harkavy-Friedman J, Burke AK, Sher L, Baca-Garcia E, Sullivan GM, et al. Family history of suicidal behavior and early traumatic experiences: Additive effect on suicidality and course of bipolar illness? Journal of Affective Disorders2008;109(1-2):5763. Available from: https://doi.org/10.1016%2Fj.jad.2007.12.225
  70. Baca-Garcia E, Perez-Rodriguez MM, Saiz-Gonzalez D, Basurte-Villamor I, Saiz-Ruiz J, Leiva-Murillo JM, et al. Variables associated with familial suicide attempts in a sample of suicide attemptersProgress in Neuro-Psychopharmacology and Biological Psychiatry2007;31(6):13121316. Available from: https://doi.org/10.1016/j.pnpbp.2007.05.019
  71. Preuss UW, Schuckit MA, Smith TL, Barnow S, Danko GP. Mood and anxiety symptoms among 140 children from alcoholic and control familiesDrug and Alcohol Dependence2002;67(3):235242. Available from: https://doi.org/10.1016/s0376-8716(02)00076-5
  72. Cole DA, Rehm LP. Family interaction patterns and childhood depressionJournal of Abnormal Child Psychology 1986;14(2):297314. Available from: https://doi.org/10.1007/BF00915448
  73. Garber J. Depression and the Family. In: Psychopathology and the Family. (pp. 225-280Elsevier. 2005.
  74. Avenevoli S, Stolar M, Li J, Dierker L, Merikangas KR. Comorbidity of depression in children and adolescents: models and evidence from a prospective high-risk family studyBiological Psychiatry2001;49(12):10711081. Available from: https://doi.org/10.1016/S0006-3223(01)01142-8
  75. Beidel DC, Turner SM. At Risk for Anxiety: I. Psychopathology in the Offspring of Anxious ParentsJournal of the American Academy of Child and Adolescent Psychiatry1997;36(7):918924. Available from: https://doi.org/10.1097/00004583-199707000-00013
  76. Andrews G, Stewart G, Allen R, Henderson AS. The genetics of six neurotic disorders: a twin studyJournal of Affective Disorders1990;19(1):2329. Available from: https://doi.org/10.1016/0165-0327(90)90005-s
  77. Mufson L, Weissman MM, Warner V. Depression and anxiety in parents and children: A direct interview studyJournal of Anxiety Disorders1992;6(1):113. Available from: https://doi.org/10.1016/0887-6185(92)90021-X
  78. Cicchetti D, Toth SL. The development of depression in children and adolescentsAmerican Psychologist1998;53(2):221241. Available from: https://doi.org/10.1037//0003-066x.53.2.221
  79. Petersen AC, Compas BE, Brooks-Gunn J, Stemmler M, Ey S, Grant KE. Depression in adolescenceAmerican Psychologist1993;48(2):155168. Available from: https://doi.org/10.1037//0003-066x.48.2.155
  80. Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, et al. Antidepressant effects of ketamine in depressed patientsBiological Psychiatry2000;47(4):351354. Available from: https://doi.org/10.1016/s0006-3223(99)00230-9
  81. Dean J, Keshavan M. The neurobiology of depression: An integrated viewAsian Journal of Psychiatry2017;27:101111. Available from: https://doi.org/10.1016/j.ajp.2017.01.025
  82. Nutt DJ. Relationship of neurotransmitters to the symptoms of major depressive disorderThe Journal of Clinical Psychiatry2008;69(Suppl E1):47. Available from: https://pubmed.ncbi.nlm.nih.gov/18494537/
  83. Moret C, Briley M. The importance of norepinephrine in depressionNeuropsychiatr Dis Treat2011;7(Suppl 1):913. Available from: https://doi.org/10.2147/NDT.S19619
  84. Bligh-Glover W, Kolli TN, Shapiro-Kulnane L, Dilley GE, Friedman L, Balraj E, et al. The serotonin transporter in the midbrain of suicide victims with major depressionBiological Psychiatry2000;47(12):10151024. Available from: https://doi.org/10.1016/s0006-3223(99)00313-3
  85. Arango V, Underwood MD, Boldrini M, Tamir H, Kassir SA, Chi HS, et al. Serotonin 1A Receptors, Serotonin Transporter Binding and Serotonin Transporter mRNA Expression in the Brainstem of Depressed Suicide VictimsNeuropsychopharmacology2001;25(6):892903. Available from: https://doi.org/10.1016/s0893-133x(01)00310-4
  86. Capuron L, Miller AH. Cytokines and psychopathology: Lessons from interferon-αBiological Psychiatry2004;56(11):819824. Available from: https://doi.org/10.1016/j.biopsych.2004.02.009
  87. Yadid G, Friedman A. Dynamics of the dopaminergic system as a key component to the understanding of depressionProgress in Brain Research2008;172:265286. Available from: https://doi.org/10.1016/S0079-6123(08)00913-8
  88. Berhow MT, Russell DS, Terwilliger RZ, Beitner-Johnson D, Self DW, Lindsay RM, et al. Influence of neurotrophic factors on morphine- and cocaine-induced biochemical changes in the mesolimbic dopamine systemNeuroscience1995;68(4):969979. Available from: https://doi.org/10.1016/0306-4522(95)00207-Y
  89. Nestler EJ, Jr. WAC. The Mesolimbic Dopamine Reward Circuit in DepressionBiological Psychiatry2006;59(12):11511159. Available from: https://doi.org/10.1016/j.biopsych.2005.09.018
  90. Cyr M, Morissette M, Barden N, Beaulieu S, Rochford J, Paolo TD. Dopaminergic activity in transgenic mice underexpressing glucocorticoid receptors: effect of antidepressantsNeuroscience2001;102(1):151158. Available from: https://doi.org/10.1016/S0306-4522(00)00444-9
  91. D’haenen HA, Bossuyt A. Dopamine D2 receptors in depression measured with single photon emission computed tomographyBiological Psychiatry1994;35(2):128132. Available from: https://doi.org/10.1016/0006-3223(94)91202-5
  92. Dunlop BW, Nemeroff CB. The Role of Dopamine in the Pathophysiology of DepressionArchives Of General Psychiatry2007;64(3):327337. Available from: https://doi.org/10.1001/archpsyc.64.3.327
  93. Itoi K, Sugimoto N. The Brainstem Noradrenergic Systems in Stress, Anxiety and DepressionJournal of Neuroendocrinology2010;22(5):355361. Available from: https://doi.org/10.1111/j.1365-2826.2010.01988.x
  94. Drevets WC, Bogers W, Raichle ME. Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolismEuropean Neuropsychopharmacology2002;12(6):527544. Available from: https://doi.org/10.1016/s0924-977x(02)00102-5
  95. Stahl SM, Stahl SM. Essential Psychopharmacology: Neuroscientific Basis and Practical Applications. (pp. 1-601Cambridge University Press. 2000.
  96. Dopheide JA. Recognizing and treating depression in children and adolescentsAmerican Journal of Health-System Pharmacy2006;63(3):233243. Available from: https://doi.org/10.2146/ajhp050264
  97. Bostic JQ, Rubin DH, Prince J, Schlozman S. Treatment of Depression in Children and AdolescentsJournal of Psychiatric Practice2005;11(3):141154. Available from: https://doi.org/10.1097/00131746-200505000-00002
  98. Hazell P. Updates in treatment of depression in children and adolescentsCurrent Opinion in Psychiatry2021;34(6):593599. Available from: https://doi.org/10.1097/yco.0000000000000749
  99. Defilippis M, Wagner KD. Management of Treatment-Resistant Depression in Children and AdolescentsPediatric Drugs2014;16(5):353361. Available from: https://doi.org/10.1007/s40272-014-0088-y
  100. Sommi RW, Crismon ML, Bowden CL. Fluoxetine: A Serotonin-specific, Second-generation AntidepressantPharmacotherapy1987;7(1):114. Available from: https://doi.org/10.1002/j.1875-9114.1987.tb03496.x
  101. Emslie GJ, Rush AJ, Weinberg WA, Kowatch RA, Carmody T, Mayes TL. Fluoxetine in child and adolescent depression: Acute and maintenance treatmentDepress Anxiety1998;7(1):3239. Available from: https://doi.org/10.1002/(sici)1520-6394(1998)7:1%3C32::aid-da4%3E3.0.co;2-7
  102. Riddle MA, King RA, Hardin MT, Scahill L, Ort SI, Chappell P, et al. Behavioral Side Effects of Fluoxetine in Children and AdolescentsJournal of child and adolescent psychopharmacology1990;1(3):193198. Available from: https://pure.johnshopkins.edu/en/publications/behavioral-side-effects-of-fluoxetine-in-children-and-adolescents
  103. Emslie GJ, Heiligenstein JH, Wagner KD, Hoog SL, Ernest DE, Brown E, et al. Fluoxetine for Acute Treatment of Depression in Children and Adolescents: A Placebo-Controlled, Randomized Clinical TrialJournal of the American Academy of Child and Adolescent Psychiatry2002;41(10):12051215. Available from: https://doi.org/10.1097/00004583-200210000-00010
  104. Gunlicks-Stoessel M, Westervelt A, Reigstad K, Mufson L, Lee S. The role of attachment style in interpersonal psychotherapy for depressed adolescentsPsychotherapy Research2019;29(1):7885. Available from: https://doi.org/10.1080/10503307.2017.1315465
  105. Kovacs M. Next steps for research on child and adolescent depression preventionAmerican Journal of Preventive Medicine2006;31(6, SUPPLEMENT 1):184185. Available from: https://doi.org/10.1016/j.amepre.2006.07.008
  106. Carnevale TD. Universal adolescent depression prevention programs: a reviewJournal of School Nursing2013;29(3):181195. Available from: https://doi.org/10.1177/1059840512469231

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