Yadav Mithlesh 1*, Maheshwari Monika 1, Vaishali 2, Arvind Kumar 2, Pathak Devender 1
- Rajiv Academy for Pharmacy, Delhi-Mathura Highway, Chhattikara-281006, Mathura, India
- S. D. College of Pharmacy & Vocational Studies, Muzaffarnagar, (U.P.), India
Abstract
Equimolar quantity of 2-aminothiophenol and ethylchloroacetate was condensed and the solid mass obtained was refluxed. The compound obtained was refluxed with 4-aminoacetophenone to produce 3(4'-acetylphenylamino) 1,4-benzothiazine. The 3(4'-acetylphenylamino)1,4-benzothiazine was reacted with corresponding aldehyde to give 3[4'-(3"-substituted-2"-propenone-1"-yl) phenylamino]1,4-benzothiazine. The above synthesized compounds and guanidine nitrate were refluxed to afford 3[4'(2"-amino-4"- substituted-phenyl)-pyrimidine-4"yl)phenylamino]1,4-benzothiazine. The structures of the newly synthesized compounds were elucidated on the basis of elemental analysis, FTIR and 1H-NMR and have been screened for antimicrobial activity.
