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Journal of Pharmaceutical Research

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Synthesis, Physical Characterization and In Silico Study of Novel Schiff Base
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Journal of Pharmaceutical Research

DOI: 10.18579/jopcr/v24.i1.5

Year: 2025, Volume: 24, Issue: 1, Pages: 16-21

Original Article

Synthesis, Physical Characterization and In Silico Study of Novel Schiff Base

Shubham N Karle1,∗, Neha R Khilare1, Prerana D Kalyankar1, Megha T Salve1

1Department of Bachelor of Pharmacy, Shivajirao Pawar College of Pharmacy, Ahilyanagar, Maharashtra, India

*Corresponding Author
Email: [email protected]

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Now a days treatment of infectious diseases is a challenging issue faced by the medical community. There are bunch of marketed drugs held modified pharmacological and toxicological properties and probably Schiff bases are versatile C=N (Imine) containing compounds possessing broad spectrum of biological activity and showed some degree of antibacterial, cytotoxic effects, antifungal, and antimalarial. In this research work a novel SB’s derivative has been designed, synthesized by using green method, and evaluated to explore physical characterization such as purity assessment of synthesized product by using TLC technique, spectral analysis by using IR spectroscopy, melting point determination by conventional method, molecular docking by using various computerized software, solubility determination by using various polar and non-polar solvent. The aim behind this research is to focus on green synthetic procedure used in the synthesis of novel Schiff bases, physical characterization and in silico study to find the most efficient method to get high yield in lesser time along with environment friendly.

Keywords: Synthesis, Evaluation, Spectral Analysis, ADMET prediction, Molecular Docking

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Copyright

© 2024 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) 

  • 23 March 2025

Year: 2025, Volume: 24, Issue: 1


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