Mayur Karvekar *, Arshad Bashir Khan
- Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, KA, India
Abstract
Purpose: A review on sustained release drug delivery using polymer matrix with emphasis on its contemporary usage and future trends.Approach: An introduction to sustained release drug delivery system (SR DDS), followed by its rationale, advantages, disadvantages, criteria of a drug to be met to formulate sustained release formulations, classification of matrix tablets, classification of polymers, its mechanism and recent advancements.Finding: Recent studies indicate that sustained delivery for a very long period, in terms of months is possible using suitable polymer matrices. Also, challenging drug candidates such as proteins are now successfully delivered as sustained release dosage forms.Conclusion: Sustained release DDS, since 1940s has evolved in different types of dosage forms for sustained effect but future scope will be to treat chronic diseases providing sustained effect.
References
- Pundir S, Badola A, Sharma D. Sustained release matrix technology and recent advance in matrix drug delivery system: a review. International Journal of drug research and technology. 2017 Feb 28; 3(1):8.
- Kumar V, Prajapati SK, Soni GC, Singh M, Kumar N. Sustained release matrix type drug delivery system: a review. World journal of pharmacy and pharmaceutical sciences. 2012 Sep 5;1(3):934-60.
- Jaimini M, Kothari AH. Sustained release matrix type drug delivery system: a review. Journal of Drug Delivery and Therapeutics. 2012 Nov 15; 2(6).
- Gandhi A, Hari Kumar SL. Recent Trends in Sustained Release Drug Delivery System.
- Karna S, Chaturvedi S, Agrawal V, Alim M. Formulation approaches for sustained release dosage forms: a review. Asian J Pharm Clin Res. 2015;8(5):46-53.
- Pundir S, Badola A, Sharma D. Sustained release matrix technology and recent advance in matrix drug delivery system: a review. International Journal of drug research and technology. 2017 Feb 28; 3(1):8.
- Shargel L, Wu-Pong S, Yu AB. Applied biopharmaceutics & pharmacokinetics. McGraw-Hill; 2007.
- Schall R, M�ller FR, M�ller FO, Luus HG. Bioequivalence of controlled-release calcium antagonists. Clinical pharmacokinetics. 1997 Jan 1; 32(1):75-89.
- Abdel-Rahman SI, Mahrous GM, El-Badry M. Preparation and comparative evaluation of sustained release metoclopramide hydrochloride matrix tablets. Saudi Pharmaceutical Journal. 2009 Oct 31; 17(4):283-8.
- Asghar LF, Mantha N. Design and evaluation of ethyl cellulose based matrix tablets of ibuprofen with pH modulated release kinetics. Indian journal of pharmaceutical sciences. 2008; 70(5):596.
- Gothi GD. Study on design and development of sustained release tablets of metoprolol succinate. Journal of Global Pharma Technology. 2010 Mar 3; 2(2).
- Basak SC, Reddy BJ, Mani KL. Formulation and release behaviour of sustained release ambroxol hydrochloride HPMC matrix tablet. Indian Journal of Pharmaceutical Sciences. 2006; 68(5).
- Dhat S, Aphale S, Bagul U, Tagalpallewar A, Vanshiv S, Shah N. Effect of Two Different Diluents On Release Profile Of Aceclofenac From Sustained Release Matrix Tablets Using Gum Damar As Release Retardant. International Journal of Pharmacy and Pharmaceutical Sciences. 2011;3(4):30713
- Aulton ME. Pharmaceutics: The Science of Dosage Form Design. 2nd ed, London: Churchill livingstone; 2005.p. 296-298.
- Poddar RK, Rakha P, Singh SK, Mishra DN. Bioadhesive Polymers as a Platform for Drug Delivery: Possibilities and Future Trends. Research Journal of Pharmaceutical Dosage Forms and Technology. 2010; 2(1):1-6.
- Satturwar PM, Fulzele SV, Dorle AK. Biodegradation and in vivo biocompatibility of rosin: a natural film-forming polymer. AAPS PharmSciTech. 2003 Dec 1;4(4):434-9.
- Diwedi RO, Alexandar A, Chandrasekar MJ. Preparation and in vitro evaluation of sustained release tablet formulations of metformin HCL. Asian Journal of Pharmaceutical and Clinical Research. 2012; 5(1):45-8.
- Hemnani M, Patel U, Patel G, Daslaniya D, Shah A, Bhimani B. Matrix tablet: A tool of Controlled drug delivery. American Journal of Pharm Tech Research. 2011;1(4):127-43.
- Robinson JR, Jantzen GM. Sustained-and controlled-release drug-delivery systems. InModern Pharmaceutics, Fourth Edition 2002 May 24. CRC Press.
- Dokoumetzidis A, Macheras P. A century of dissolution research: from Noyes and Whitney to the biopharmaceutics classification system. International journal of pharmaceutics. 2006 Sep 14; 321(1):1-1.
- Wu F, Jin T. Polymer-based sustained-release dosage forms for protein drugs, challenges, and recent advances. Aaps Pharmscitech. 2008 Dec 1; 9(4):1218- 29.
- Karode NP, Prajapati VD, Solanki HK, Jani GK. Sustained release injectable formulations: its rationale, recent progress and advancement.
- Patnaik AN, Nagarjuna T, Thulasiramaraju TV. Sustained release drug delivery system: a modern formulation approach. International Journal of Research in Pharmaceutical and Nano Sciences. 2013; 2(5):586-601.
