S. Vyawahare Neeraj 1*, R. Pujari Rohini 1, G. Kagathara Virendra 1, R. Gangurde Prajakta 1, L. Bodhankar Subhash 2, A. Hadambar Avinash 1
- Department of Pharmacology, AISSMS College of Pharmacy, Kennedy Road, Pune-411 001, India
- Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune-411 038, India
Abstract
Argyreia speciosa (AS), a long woody climber is commonly known as Vryddhadaru in Sanskrit. It is distributed throughout India upto altitude of 300 m. It is scientifically documented for its antiinflammatory, antiarthritic, immunomodulatory, antistress and aphrodiasiac activities. The roots and seeds are used as restorative in various nervous system disorders. The roots are also reported to possess nootropic, antimicrobial, diuretic properties and used in chronic peptic ulcer, gonorrhoea and rheumatism. In the present study the central nervous system (CNS) activity of the hydroalcoholic extract of Argyreia speciosa roots at different doses (100, 200, 400 mg/kg) was studied using various standard paradigms. The results revealed that the Argyreia speciosa extract significantly increased discrimination index in object recognition test, reduced 5HTP induced head twiches, potentiated haloperidol induced catalepsy, delayed the onset of pentylenetetrazole induced convulsions and antagonised amphetamine induced motor hyperactivity.
