• P-ISSN 0973-7200 E-ISSN 2454-8405
  • Follow us

Journal of Pharmaceutical Research


Journal of Pharmaceutical Research

Year: 2023, Volume: 22, Issue: 2, Pages: 63-68

Original Article

Clinical Study and Assessment of Efficacy of Polyherbal Combination (KNDBHU) in COVID 19 Patients


Even three years after the COVID-19 pandemic initially appeared in December of the year 2019, it is still raging over the globe. There have been numerous attempts to use well-known medications in new ways to treat COVID-19 infection. Many nations, including India, implemented a series of lock downs in an effort to limit the pandemic. Sanitation practices, social seclusion, routine mask wearing, testing, and quarantining of suspected carriers were among the recommended methods for limiting the illness. Numerous treatment strategies have also been used to prevent and treat the illness, but no formal studies using well-known Ayurvedic formulations or any polyherbal combinations have been conducted. A clinical study was planned to test the noble polyherbal combination containing Withania somnifera, Tinospora cordifolia, Moringa oleifera, Adhatoda vasica, Piper longum, Glycyrrhiza glabra, Ocimum sanctum and Curcuma longa. The study checked the rate of symptom remission in individuals receiving the polyherbal combination in addition to standard of care (SoC) to that in patients with mild and moderate symptoms of COVID-19 infections receiving SoC alone. A prospective randomized interventional clinical study was planned comparing outcomes in 2 cohorts with mild to moderate COVID-19 as under. Cohort-1 was trialled with conventional treatment as per government advisory. Cohort-2 was trialled with polyherbal combination and with conventional treatment as per government advisory. With the current add-on Polyherbal regimen, an early clinical improvement in breathlessness was seen along with early ageusia and cough reduction when compared with conventional treatment. The polyherbal combination (KNDBHU) enhanced recovery in COVID-19 Patients. Given the lack of hospital beds in India, the median length of hospital stays was shortened; this development is significant.

Keywords: Covid­19, Add on polyherbal combinationregimen for Corona virus, Early Clinical Improvement, Shortened hospital stays


  1. Boulware DR, Pullen MF, Bangdiwala AS, Pastick KA, Lofgren SM, Okafor EC, et al. A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19New England Journal of Medicine2020;383:517525. Available from: https://doi.org/10.1056/NEJMoa2016638
  2. Geleris J, Sun Y, Platt J, Zucker J, Baldwin M, Hripcsak G, et al. Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19New England Journal of Medicine2020;382:24112418. Available from: https://doi.org/10.1056/NEJMoa2012410
  3. Beigel JH, Tomashek KM, Dodd LE, Mehta AK, Zingman BS, Kalil AC, et al. ACTT-1 Study Group Members. Remdesivir for the Treatment of Covid-19 - Final ReportNew England Journal of Medicine2020;383:18131826. Available from: https://doi.org/10.1056/NEJMoa2007764
  4. Grein J, Ohmagari N, Shin D, Diaz G, Asperges E, Castagna A, et al. Compassionate Use of Remdesivir for Patients with Severe Covid-19New England Journal of Medicine2020;382:23272336. Available from: https://doi.org/10.1056/NEJMoa2007016
  5. Wang Y, Zhang D, Du G, Du R, Zhao J, Jin Y, et al. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trialLancet2020;395(10236):15691578. Available from: https://doi.org/10.1016/S0140-6736(20)31022-9
  6. Tillu G, Chaturvedi S, Chopra A, Patwardhan B. Public Health Approach of Ayurveda and Yoga for COVID-19 ProphylaxisThe Journal of Alternative and Complementary Medicine2020;26(5):360364. Available from: https://doi.org/10.1089/acm.2020.0129
  7. Chatterjee P, Anand T, Singh KJ, Rasaily R, Singh R, Das S, et al. Healthcare workers & SARS-CoV-2 infection in India: A case-control investigation in the time of COVID-19Indian Journal of Medical Research2020;151(5):459467. Available from: https://doi.org/10.4103/ijmr.IJMR_2234_20
  8. Guidelines on Clinical management of COVID19Government of India, Ministry of Health & Family Welfare, Directorate General of Health Services (EMR Division). Available from: https://www.mohfw.gov.in/pdf/GuidelinesonClinicalManagementofCOVID1912020.pdf
  9. Sahin AR, Erdogan A, Agaoglu PM, Dineri Y, Cakirci AY, Senel ME, et al. 2019 Novel Coronavirus (COVID-19) Outbreak: A Review of the Current LiteratureEurasian Journal of Medicine and Oncology2020;4(1):17. Available from: https://www.ejmo.org/10.14744/ejmo.2020.12220/
  10. Dwivedi KN, Mishra A, Singh RK. Acute and Subchronic Toxicity and LC-MS Fingerprinting of a Polyherbal Formulation (KNDBHU) used for COVID-19 ManagementJournal of Pharmaceutical Research2023;22(1):5054. Available from: https://doi.org/10.18579/jopcr/v22.1.23.7
  11. Lozada-Nur F, Chainani-Wu N, Fortuna G, Sroussi H. Dysgeusia in COVID-19: Possible Mechanisms and ImplicationsOral Surgery Oral Medicine Oral Pathology Oral Radiology2020;130(3):344346. Available from: https://doi.org/10.1016/j.oooo.2020.06.016
  12. Gandhi RT, Lynch JB, Rio Cd. Mild or Moderate Covid-19New England Journal of Medicine2020;383:17571766. Available from: https://doi.org/10.1056/NEJMcp200924
  13. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical Characteristics of Coronavirus Disease 2019 in ChinaNew England Journal of Medicine2020;382:17081720. Available from: https://doi.org/10.1056/NEJMoa2002032
  14. Kumar A, Nayar KR, Koya SF. COVID-19: Challenges and its consequences for rural health care in IndiaPublic Health in Practice2020;1:12. Available from: https://doi.org/10.1016/j.puhip.2020.100009


© 2023 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/


Subscribe now for latest articles and news.