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Journal of Pharmaceutical Research

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Studies of Antibacterial Activity of the Seed Extract of Solanum surattense Burm. F .
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Journal of Pharmaceutical Research

DOI: 10.18579/jopcr/v21i4.22.24

Year: 2022, Volume: 21, Issue: 4, Pages: 123-127

Original Article

Studies of Antibacterial Activity of the Seed Extract of Solanum surattense Burm. F .

Menavath Tulasi Ram Naik​ ✉ 1 , Sai Kushal Gunturu 1 , Afzal Basha Shaik 1 , Yadlapalli Jaya Prasanth Babu 1 , Sardena Siyonu Kumari 1

1 Department of Pharmaceutical Analysis, Vignan Pharmacy College, Vadlamudi, Guntur, A.P, 522213, India

Corresponding author ✉: [email protected]

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

 

Crude Flavonoids extracted from crushed seeds of dried ripe fruits of Solanum surattense Burm F. were screened for antimicrobial activity against two bacteria – Streptococcus mutans and Aggregatibacter actinomycetemcomitans – which were found to be major contributers for occurrence of Dental caries. Minimum inhibitory concentration, Minimum bactericidal concentration, and Time Kill curve of the extract against each sensitive test pathogen, were evaluated. The flavonoid extract showed good antimicrobial activity against Streptococcus mutans than towards Aggregatibacter actinomycetemcomitans. MIC & MBC of Streptococcus mutans is 25µg/mL & 25µg/mL respectively. MIC & MBC of Aggregatibacter actinomycetemcomitans is 50µg/mL & 50µg/mL respectively. Time Kill Curve of Streptococcus mutans and Aggregatibacter actinomycetemcomitans was 2hr and 2hr respectively.

 

Keywords: ­ Solanum surattense, Streptococcus mutans, Aggregatibacter actinomycetemcomitans, Minimum inhibitory concentration, Minimum bactericidal concentration, Time kill curve

References

  1. Abreu AC, Mcbain AJ, Simões M. Plants as sources of new antimicrobials and resistance-modifying agents. Nat Prod Rep. 2012;29(9):1007–1021. Available from: https://doi.org/10.1039/c2np20035j
  2. Saxena M, Nema JS, Dharmendra R, Gupta S, A. Phytochemistry of medicinal plants. Journal of pharmacognosy and phytochemistry. 2013;1(6):168–182. Available from: https://www.phytojournal.com/archives/2013/vol1issue6/PartA/26.pdf
  3. Samy RP, Gopalakrishnakone P. Therapeutic Potential of Plants as Anti-microbials for Drug Discovery. Evid Based Complement Alternat Med. 2010;7(3):283–294. Available from: https://doi.org/10.1093%2Fecam%2Fnen036
  4. Selwitz RH, Ismail AI, Pitts NB. Dental caries. Lancet. 2007;369(9555):51–59. Available from: https://doi.org/10.1016/s0140-6736(07)60031-2
  5. Raja M, Ummer F, Dhivakar CP. Aggregatibacter actinomycetemcomitans - a tooth killer? J Clin Diagn Res. 2014;8(8):ZE13–16. Available from: https://doi.org/10.7860/jcdr/2014/9845.4766
  6. Mosaddad SA, Tahmasebi E, Yazdanian A, Rezvani MB, Seifalian A, Yazdanian M, et al. Oral microbial biofilms: an update. European Journal of Clinical Microbiology & Infectious Diseases. 2019;38(11):2005–2019. Available from: https://doi.org/10.1007/s10096-019-03641-9
  7. Balakrishnan M, Simmonds RS, Tagg JR. Dental caries is a preventable infectious disease. Aust Dent J. 2000;45(4):235–280. Available from: https://doi.org/10.1111/j.1834-7819.2000.tb00257.x
  8. Hamada S, Koga T, Ooshima T. Virulence factors of Streptococcus mutans and dental caries prevention. J Dent Res. 1984;63(3):407–411. Available from: https://doi.org/10.1177/00220345840630031001
  9. Loesche WJ. Role of Streptococcus mutans in human dental decay. Microbiol Rev. 1986;50(4):353–380. Available from: https://doi.org/10.1128%2Fmr.50.4.353-380.1986
  13. Shahiladevi S, Jayanthi G, Jegadeesan M. Preliminary phytochemical studies on solanum surattense burm. Seeds. Anc Sci Life. 2006;26(1-2):59–64. Available from: https://pubmed.ncbi.nlm.nih.gov/22557226/
  14. Kumar P. A review on the pharmaceutical activity of Solanum surattense. GSC Advanced Research and Reviews. 2021;7(3):38–44. Available from: https://doi.org/10.30574/gscarr.2021.7.3.0128
  15. Sheeba E. Antibacterial Activity of <i>Solanum surattense</i> Burm. F. Kathmandu University Journal of Science, Engineering and Technology. 2010;6(1):1–4. Available from: https://doi.org/10.3126/kuset.v6i1.3278
  16. Tekuri SK, Pasupuleti SK, Konidala KK, Amuru SR, Bassaiahgari P, Pabbaraju N. Phytochemical and pharmacological activities of Solanum surattense Burm. f. - A review. J Appl Pharm Sci. 2019;9(3):126–136. Available from: https://doi.org/10.7324/JAPS.2019.90318
  17. Asif C, Adila S, Kiran A, Tanveer A. Phytochemistry and Biological Importance of Solanumsurattense. World Applied Sciences Journal. 2018;36(3):529–536. Available from: http://dx.doi.org/10.5829/idosi.wasj.2018.529.536
  18. Lucas EH, Pearson K, Lewis RW, Vincent B. Preparation of crude plant extracts and their assay for presence of antibacterial substances. Journal of Food Science. 1948;13(1):82–88. Available from: https://doi.org/10.1111/j.1365-2621.1948.tb16597.x
  20. George CS, Haridas H, Jose A, Krishnan D, Jayachandran TP. A review of phytochemical screening and pharmacognostic study of Pleurotusflorida. World Journal of Pharmaceutical Research. 2016;5(4):456–462. Available from: https://www.cabdirect.org/globalhealth/abstract/20163186255
  23. Fathiazad F, Delazar A, Amiri R, Sarker SD. Extraction of flavonoids and quantification of rutin from waste tobacco leaves. Iranian Journal of Pharmaceutical Research. 2006;3:222–227. Available from: http://ijpr.sbmu.ac.ir/article_680_3d1148b62e35737af3b3fc759431d0ca.pdf
  24. Schwalbe R, Steele-Moore L, Goodwin AC., eds. Antimicrobial Susceptibility Testing Protocols (1). (pp. 1-432) CRC Press. 2007.

Copyright

© 2022 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) 

  • 04 March 2023

Year: 2022, Volume: 21, Issue: 4


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