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Journal of Pharmaceutical Research

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An Overview on Pashanabedha Medicinal Plants
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Journal of Pharmaceutical Research

DOI: 10.18579/jopcr/v22.3.23.24

Year: 2023, Volume: 22, Issue: 3, Pages: 133-141

Review Article

An Overview on Pashanabedha Medicinal Plants

T H Sunitha1,*, V B Narayanaswamy1, E Akila1

1Department of Pharmacognosy, RR College of Pharmacy, Bangalore, Karnataka, India

*Corresponding Author
Email: [email protected]

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

One of the major kidney diseases that needs a well-targeted therapeutic approach is urolithiasis. For the treatment of lithiasis, a number of medications are available, including diuretics and stone inhibitors, however clinical examination of these medications has revealed a frequency of relapses, adverse effects, and drug interactions. This has served as the justification for the development of new antilithiatic medications, and the hunt for novel molecules has now included herbal medications that provide superior defence and lower relapse rates. Plant-based medications are becoming more popular and are being researched for a variety of illnesses, including lithiasis. A set of medicinal plants known as pashanabheda (literally, ”stonesolving”) are utilised by Ayurvedic doctors in India as anti-urolithiatic medications. The present article reviews the antilithiatic activity of some of the medicinal plants. Here attempt is made to review a few medicinal plants with documented anti-urolithiatic action. In this study, some of the significant plants noted for their antilithiatic effects have been highlighted.

Keywords: Urolithiatic; AntiUrolithiatic; Maceration; Turbidimetry; Calcium Oxalate

References

  1. Niharika M, Suchitha N, Akhila S, Himabindhu J, Ramanjaneyulu K. Evaluation of in vitro anti-urolithiatic activity of Gossypium herbaceum. Journal of Pharmaceutical Sciences and Research. 2018;10(5):1236–1243. Available from: https://www.jpsr.pharmainfo.in/Documents/Volumes/vol10Issue05/jpsr10051858.pdf
  2. Shelke T, Wayal S, Gunjegaokar S, Gaikwad S, Shirsath A, Hadke S. An overview on Indian medicinal plants with anti-urolithiatic activity. J. Pharm. Res. Clin. Pract. 2014;4:33–40. Available from: https://www.researchgate.net/publication/343049655_An_Overview_on_Indian_Medicinal_Plants_with_Antiurolithiatic_Activity
  3. Nagal A, Singla RK. Herbal Resources with Antiurolithiatic Effects: A Review. Indo Global Journal of Pharmaceutical Sciences. 2013;03(01):06–14. Available from: https://doi.org/10.35652/IGJPS.2013.02
  4. Hwisa NT, Assaleh FH, Gindi S, Melad FE, Chandu BR, Katakam P. A study on anti-urolithiatic activity of Melia azadirachta L. aqueous extract in rats. Am J Pharmacol Sci. 2014;2(1):27–31. Available from: https://doi.org/10.12691/ajps-2-1-6
  5. Arya P. Kidney stone formation and use of medicinal plants as anti-urolithiatic agents. Universal Journal of Pharmaceutical Research. 2017;2(4):42–48. Available from: https://ujpr.org/index.php/journal/article/view/71
  7. Goyal PK, Verma SK, Sharma AK. Antilithiatic potential of Vernonia cinerea against calcium oxalate calculi in experimental rats. The Journal of Phytopharmacology. 2017;6(2):149–155. Available from: https://www.phytopharmajournal.com/Vol6_Issue2_13.pdf
  9. Bawari S, Sah AN, Tewari D. Antiurolithiatic Activity of Daucus carota: An In vitro Study. Pharmacognosy Journal. 2018;10(5):880–884. Available from: https://www.phcogj.com/sites/default/files/PharmacognJ-10-5-880.pdf
  10. Dinnimath BM, Jalalpure SS. Antioxidant and Antiurolithiatic Efficacy of Aerva lanata (L) Fractions by in vitro and in vivo Screening Techniques. Indian Journal of Pharmaceutical Education and Research. 2018;52(3):426–436. Available from: https://www.ijper.org/sites/default/files/IndJPhaEdRes_52_3_426.pdf
  12. Sasikala V, Radha SR, Vijayakumari B. In vitro evaluation of Rotula aquatica Lour. for antiurolithiatic activity. Journal of Pharmacy Research. 2013;6(3):378–382. Available from: https://doi.org/10.1016/j.jopr.2013.02.026
  13. Agarwal K, Varma R. A medicinal plant with promising antiurolithiatic activity: Ocimum gratissimum L. International Journal of Pharmaceutical Sciences and Drug Research. 2014;6(1):78–81. Available from: https://www.ijpsdr.com/index.php/ijpsdr/article/view/304
  14. Kumar A, Nandi MK, Kumar B, Kumar A, Kumar R, Singh AK, et al. Antiurolithiasis, Antioxidant, Anti-inflammatory, Analgesic, and Diuretic Activity of Ethanolic Extract of Seeds of Caesalpinia bonducella. International Journal of Pharmaceutical Investigation. 2021;11(3):306–311. Available from: https://jpionline.org/storage/2023/05/IntJPharm-Investigation-11-3-306.pdf
  16. Hosseinzadeh H, Khooei AR, Khashayarmanesh Z, VMS. Anti-urolithiatic activity of Pinus eldarica Medw: fruits aqueous extract in rats. Urology Journal. 2010;7(4):232–239. Available from: https://pubmed.ncbi.nlm.nih.gov/21170851/
  17. Kushwaha S, Tyagi CK. Evaluation of the Antiurolithiatic Activity of the Extract of Boswellia serrata Roxb in Rats. Journal of Pharmaceutical Research International. 2021;33(62):243–249. Available from: https://journaljpri.com/index.php/JPRI/article/view/5276
  18. Phatak RS, Hendre AS. In-vitro anti-urolithiatic activity of Kalanchoe pinnata extract. International Journal of Pharmacognosy and Phytochemical Research. 2015;7(2):275–284. Available from: https://impactfactor.org/PDF/IJPPR/7/IJPPR,Vol7,Issue2,Article13.pdf
  24. İlhan M, Ergene B, Süntar I, Özbilgin S, Çitoğlu GS, Demirel MA, et al. Preclinical evaluation of anti-urolithiatic activity of Viburnum opulus L. on sodium oxalate-induced urolithiasis rat model. 2014. Available from: https://doi.org/10.1155/2014/578103
  25. Rahim NFA, Muhammad N, Abdullah N. Investigation on antiurolithiatic activity of aqueous extract of Ananas fruit (in-vitro) IOP Conference Series: Earth and Environmental Science. 2021;736(1):012057. Available from: https://ui.adsabs.harvard.edu/abs/2021E&ES..736a2057R/abstract
  26. Konda RK, Prathyusha A. Evaluation of invitro anti-urolithiatic activity of ethanolic and methanolic leaf extracts of Acalypha indica linn. UPI Journal of Pharmaceutical, Medical and Health Sciences. 2020;2020:5–8. Available from: https://doi.org/10.38022/AJHP.2020.1101
  28. Reddy CS, Vardhaman P. Evaluation of Phoenix dactylifera fruits for Anti-urolithiatic activity. Hygeia. JD Med. 2013;5(1):135–175. Available from: https://oaji.net/articles/2017/4562-1487570788.pdf
  29. Subhashini NJ. In vitro anti-urolithiatic activity of c-phycocyanin isolated from Spirulina platensis. Asian Journal of Pharmaceutics (AJP). 2021;15(1). Available from: https://doi.org/10.22377/ajp.v15i1.3969
  30. Salama AA, El-Kassaby MI, Hassan A. Anti-urolithiatic activity of Solanum nigrum hydroalcoholic extract in ethylene glycol-induced urolithiasis in rats. Egyptian Pharmaceutical Journal. 2019;18(4):311. Available from: https://doi.org/10.4103/epj.epj_21_19
  31. Devkar RA, Chaudhary S, Adepu S, Xavier SK, Chandrashekar KS, Setty MM. Evaluation of antiurolithiatic and antioxidant potential of Lepidagathis prostrata: A Pashanbhed plant. Pharmaceutical Biology. 2016;54(7):1–9. Available from: https://doi.org/10.3109/13880209.2015.1066397
  32. Lakshmi S, Prabhakaran V, Mallikarjuna G, Gowthami A. Antilithiatic activity of Trianthema portulacastrum L. and Gymnema sylvestre R. Br. against ethylene glycol induced urolithiasis. Int J Pharm Sci Rev Res. 2014;25(1):16–22. Available from: https://globalresearchonline.net/journalcontents/v25-1/03.pdf
  33. Kaushik J, Tandon S, Bhardwaj R, Kaur T, Singla SK, Kumar J, et al. Delving into the Antiurolithiatic Potential of Tribulus terrestris Extract Through –In Vivo Efficacy and Preclinical Safety Investigations in Wistar Rats. Scientific Reports. 2019;9(1):9. Available from: https://doi.org/10.1038/s41598-019-52398-w
  37. Ali H, Nadeem A, Anwaar M, Jabeen Q. Evaluation of anti-urolithiatic potential of Moringa oleifera seed extract. Biomedical Journal of Scientific & Technical Research. 2021;36(5):28889–28895. Available from: https://biomedres.us/pdfs/BJSTR.MS.ID.005916.pdf
  38. Viel TA, Domingos CD, Monteiro APDS, Lima-Landman MT, Lapa AJ, Souccar C. Evaluation of the antiurolithiatic activity of the extract of Costus spiralis Roscoe in rats. Journal of ethnopharmacology. 1999;66(2):193–201. Available from: https://doi.org/10.1016/s0378-8741(98)00171-8
  39. Shukla A, Mourya P. Investigations for anti-urolithiatic activity of roots against Tephrosia purpurea ethylene glycol-induced renal calculi in rats. Asian Journal of Pharmacy and Pharmacology. 2016;2(2):40–43. Available from: https://ajpp.in/uploaded/p22.pdf
  42. Pandhare RB, Shende RR, Avhad MS, Deshmukh VK, Mohite PB, Sangameswaran B, et al. Anti-urolithiatic activity of Bryophyllum pinnatum Lam. hydroalcoholic extract in sodium oxalate-induced urolithiasis in rats. Journal of Traditional and Complementary Medicine. 2021;11(6):545–551. Available from: https://doi.org/10.1016/j.jtcme.2021.06.002
  45. Benalia H, Djeridane A, Bensafieddine F, Yousfi M. High in vitro antiurolithiatic effect of Pituranthos scoparius roots extracts. Pharmacologyonline. 2016;1(32):31–43. Available from: https://pharmacologyonline.silae.it/files/archives/2016/vol1/PhOL_2016_1_A005_01_Amar_31_43.pdf
  46. RSV, Perez RMG, SGP, MASZ, CGP. Antiurolithiatic activity of Raphanus sativus aqueous extract on rats. Journal of Ethnopharmacology. 1999;68(1-3):335–338. Available from: https://doi.org/10.1016/s0378-8741(99)00105-1
  48. Solomon A, Andemariam A, Tseghehannes F, Aron H, Tesfagaber M, Andemeskel Z, et al. Anti-urolithiatic activity of the leaf extracts of Maerua angolensis. 2019. Available from: https://doi.org/10.33552/APPR.2019.02.000535

Copyright

© 2023 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) 

  • 03 January 2024

Year: 2023, Volume: 22, Issue: 3


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