• P-ISSN 0973-7200 E-ISSN 2454-8405
  • Follow us

Journal of Pharmaceutical Research

Article

Development Studies On Microemulsion Gels Containing Herbal Excipients as Permeation Enhancers
  • VIEWS 44
  • PDF 40

Journal of Pharmaceutical Research

DOI: 10.18579/jopcr/v19.1.jimith

Year: 2020, Volume: 19, Issue: 1, Pages: 7-13

Original Article

Development Studies On Microemulsion Gels Containing Herbal Excipients as Permeation Enhancers

Jimit Prakashkumar Shah1, Subhabrata Ray1,∗

1Department of Pharmaceutics, Krupanidhi College of Pharmacy, Bangalore, 560035, Karnataka, India

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objective: Acyclovir is an effective antiviral medication used in the management of Herpes Simplex Virus (HSV) infections. Although acyclovir sodium exhibits high solubility, it has low permeability, resulting in suboptimal bioavailability, necessitating elevated dosages, which can lead to increased side effects. The objective of this study was to formulate an oral microemulsion gel utilising a herbal excipient to enhance the permeability and bioavailability of acyclovir, thereby minimising the required doses and associated adverse effects. Methods: Microemulsions were developed by systematically titrating different oil-to-surfactant ratios in an aqueous phase, as illustrated in a pseudo-ternary phase diagram. The evaluation included parameters, such as clarity, dilution shock, in vitro drug release, and ileal permeability. This method offers advantages such as reduced processing time, minimal exposure to high temperatures, and effective drug-loading efficiency. Findings: The stable microemulsion gel composed of Captex 200, Tween 80, ethanol, water, propylene glycol, 100% Aloe vera, and 2% Carbopol demonstrated a fourfold enhancement in ileal permeability when compared to the acyclovir sodium solution. Novelty: Aloe vera gel improves the permeation of microemulsions, thereby enhancing the intestinal permeability and bioavailability of BCS class III pharmaceuticals. This formulation has the potential to be administered through soft gel capsules.

Keywords: Acyclovir sodium, Aloe vera, BCS class III drugs, Permiability 200, Microemulsion gel, Permeability

References

  1. Lawrence MJ, Rees GD. Microemulsion-based media as novel drug delivery systems. Advanced drug delivery reviews. 2000;45(1):89–121. Available from: https://doi.org/10.1016/S0169-409X(00)00103-4
  2. Tenjarla S. Microemulsions: an overview and pharmaceutical applications. Crit Rev Ther Drug Carrier Syst. 1999;16:461–521. Available from: https://pubmed.ncbi.nlm.nih.gov/10635455/
  3. Eccleston GM. Emulsions and Microemulsions. In: Encyclopedia of Pharmaceutical Science and Technology. (Vol. 2, pp. 1066-85) CRC Press. 2007.
  4. Lawrence MJ, Warisnoicharoen W. 2006.
  5. Coneac G, Vlaia V, Olariu I, Muţ AM, Anghel DF, Ilie C, et al. Development and evaluation of new microemulsion-based hydrogel formulations for topical delivery of fluconazole. American Association of Pharmaceutical Scientists. 2015;16:889–904. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508307/pdf/12249_2014_Article_275.pdf
  6. Rangsimawong W, Wattanasri P, Tonglairoum P, Akkaramongkolporn P, Rojanarata T, Ngawhirunpat T, et al. Development of Microemulsions and Microemulgels for Enhancing Transdermal Delivery of Kaempferia parviflora Extract. AAPS PharmSciTech. 2018;19:2058–2067. Available from: https://pubmed.ncbi.nlm.nih.gov/29687193/
  7. Kurokawa M, Nagasaka K, Hirabayashi T, Uyama SI, Sato H, Kageyama T, et al. Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo. Antiviral research. 1995;27(1-2):19–37. Available from: https://pubmed.ncbi.nlm.nih.gov/7486956/
  9. phannacopeia US. Technetium-99m-disofenin injection. . Rockville, MD. United States Pharmacopeia Convention, USP-NF. 1995. Available from: https://doi.usp.org/USPNF/USPNF_M80670_04_01.html
  10. Subramanian N, Ray S, Ghosal SK, Bhadra R, Moulik SP. Formulation design of Self-micro emulsifying drug delivery system for improved oral bioavailability of Celecoxib. Biological and Pharmaceutical Bulletin. 2004;27(12):1993–1999. Available from: https://www.jstage.jst.go.jp/article/bpb/27/12/27_12_1993/_article
  11. Lewis GA, Mathieu D, Phan-Tan-Luu R. Pharmaceutical Experimental Design (1). (pp. 1-512) Boca Raton. CRC press. 1998.
  12. Li P, Ghosh A, Wagner RF, Krill S, Joshi YM, Serajuddin AT. Effect of combined use of nonionic surfactant on formation of oil-in-water microemulsions. International journal of pharmaceutics. 2005;288(1):27–34. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0378517304005356
  13. Gibson M. Pharmaceutical preformulation and formulation. (Vol. 199, pp. 1-560) 2001.
  15. Ruckenstein E. Thermodynamic approaches to microemulsions. Journal of colloid and interface science. 1998;204(1):143–150. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0021979798955552

Copyright

© 2020 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) 

  • 02 October 2024

Year: 2020, Volume: 19, Issue: 1


More articles

DON'T MISS OUT!

Subscribe now for latest articles and news.