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A Comparative Study of Lung Involvement Among Vaccinated and Unvaccinated Covid - 19 Patients
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Journal of Pharmaceutical Research

DOI: 10.18579/jopcr/v22.4.71

Year: 2023, Volume: 22, Issue: 4, Pages: 200-205

Original Article

A Comparative Study of Lung Involvement Among Vaccinated and Unvaccinated Covid - 19 Patients

S Bhuvaneshwari1,*, A T Sathiya Vinotha2, M S Umamageswari1, A Vijayamathy3, S Jeevithan4, Sabari Arasu5, N I Blesson Sha Fogarty6, Akshay Kumar7, Ashok Kumar7

1Professor & Head, Department of Pharmacology, KMCH Institute of Health Sciences & Research, Coimbatore, Tamil Nadu, India
2Associate Professor, Department of Pharmacology, KMCH Institute of Health Sciences & Research, Coimbatore, Tamil Nadu, India
3Associate Professor, Department of Pharmacology, Karuna Medical College, Palakkad
4Professor, Department of Community Medicine, KMCH Institute of Health Sciences & Research, Coimbatore, Tamil Nadu, India
5Associate Professor, Department of Radiology, KMCH Institute of Health Sciences & Research, Coimbatore, Tamil Nadu, India
6KMCH Institute of Health Sciences & Research, Coimbatore, Tamil Nadu, India
7MBBS student, KMCH Institute of Health Sciences & Research, Coimbatore, Tamil Nadu, India

*Corresponding author email: [email protected]

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

COVID-19 caused by a novel agent SARS-CoV-2 progressed to a pandemic condition and resulted in a major public health concern worldwide, leading to social and economic issues at the same time. Vaccinated people getting infected with SARS-COV2 brings a dilemma among the population whether to get vaccinated or not. The primary objective of this study is to evaluate the impact of vaccination by comparing the lung involvement in vaccinated and un vaccinated Covid – 19 patients. Retrospective anonymised data of COVID-19 inpatients who underwent HRCT scan during the second wave of pandemic were collected through a validated data collection form, from the medical records of tertiary care private medical college hospital. Vaccinated and non-vaccinated COVID-19 positive participants of 33 each were included in the study. CT severity score (CTS), D-dimer, IL-6 level, oxygen requirement and duration of hospital stay were statistically analysed using appropriate methods. The mean age of the study participants were 56.93 ± 16.01 years. There was no statistical significance between both the groups with respect to gender distribution in vaccinated and unvaccinated groups. There was a statistically significant difference in mean CTS score(p<0.001) and oxygen requirement(p<0.05) among vaccinated and unvaccinated patients. There was no statistical significance between CORADS, IL-6, D – Dimer and duration of hospital stay. In COVID-19 patients, vaccination reduces the extent of lung involvement and the need for oxygen. The COVID-19 vaccination conundrum is somehow resolved by this study, which also gives us a clear picture of the vaccine's efficacy.

Keywords

COVID­19, Vaccination, HRCT Scan, CORADS Severity

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Copyright

© 2023 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) 

  • 05 March 2024

Year: 2023, Volume: 22, Issue: 4


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