Journal of Pharmaceutical Research

Abstract

Purpose : To evaluate the hepatoprotective activity of methanolic root extracts of Memecylon malabaricum (MM), Andrographis serpyllifolia (AS) and Leucas aspera (LA) against the paracetamol induced hepatotoxicity.Approach : The methanolic root extracts of MM (family: Melastomaceae), AS (family: Acanthaceae) and LA (family: Lamiaceae) was studied at different doses and compared with standard Silymarin (25 mg/kg b.w). All the doses were administered orally. Thereafter, paracetamol induced hepatotoxicity in elevation of the serum levels of biochemical parameters like SGOT, SGPT, ALKP, TBL and CHL were studied.Findings : The rats treated with the methanolic root extracts of MM, AS, LA and silymarin showed a significant (p<0.05) decrease in all the elevated SGOT, SGPT, ALKP, TBL, CHL and significant increase (p<0.05) in TPTN and ALB levels at dose dependent manner. Pretreatment with Silymarin and methanolic root extracts MM, AS and LA produced significant antihepatotoxic activity.Conclusion : The reduction of elevated serum levels were explored by evaluated hepatoprotective activity of methanolic root extracts of MM, AS and LA against the paracetamol induced hepatotoxicity.