Journal of Pharmaceutical Research

Abstract

Present study reports analgesic activity and antioxidant activity of methanolic extracts of flowers, leaves, stems and seeds and roots of the plant C. ternatea. Hot plate and tail immersion methods were used for evaluation of central analgesic activity and acetic acid induced writhing model was used for evaluation of peripheral analgesic activity. In-vitro antioxidant activity was evaluated using DPPH, reducing power assay, lipid peroxidation and nitric oxide scavenging models.Results indicate that methanolic extract of roots at 50 mg/kg, i.p. dose produced a significant increase in reaction time (P<0.01) in tail immersion method and increase in response latency period (P<0.05, P<0.01) in hot plate method, against standard drug pentazocin.Methanolic extract significantly (P<0.01) attenuated the number of writhing when compared to standard drug paracetamol in acetic acid induced writhing model. Methanolic extract of roots of C. ternatea inhibited DPPH free radical, nitric oxide and lipid peroxidation scavenging activity at IC50 value 45.29, 52.83, 59.14 ?g/ml against corresponding standards ascorbic acid 44.91, 43.80, 52.28 ?g/ml. respectively.