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Journal of Pharmaceutical Research

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Phytochemical Screening and Comparative Anthelmintic Activity of Psidium guajava L. Leaves extract against Pheretima posthuma
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Journal of Pharmaceutical Research

DOI: 10.18579/jopcr/v20i3.ms21042

Year: 2021, Volume: 20, Issue: 3, Pages: 5-8

Original Article

Phytochemical Screening and Comparative Anthelmintic Activity of Psidium guajava L. Leaves extract against Pheretima posthuma

Dusmanta Kumar Pradhan1,*, Manas Ranjan Mishra2, Abhishek Hota3

1Raigarh College of Pharmacy, Kotrapali, Jurda, Raigarh, 496001, Chhattisgarh, India
2Gayatri College of Pharmacy, Jamadarpali, Sason, Sambalpur, 768200, Odisha, India
3Department of Animal Science, M.S. Swaminathan School of Agriculture, Centurion University   of Technology and Management, Alluri Nagar, R. Sitapur, Parlakhemundi, Gajapati, Odisha,   761211, Parlakhemundi, India

*Corresponding author email: [email protected]

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objective: Psidium guajava L. (Family: Myrtaceae.), commonly known as Guava, is a well-known traditional medicinal plant used in treatment of vomiting, diarrhea, dysentery, flatulence, gastroenteritis, abdominal distention and hyperglycemia. The present study was carried out to evaluate Phytochemical and Comparative in vitro anthelmintic activity of P. guajava leave extracts against Indian adult earthworm Pheretima posthuma. Methods: The traditional medicinal plant is used to control gastrointestinal infections. The phytochemical analysis and anthelmintic effects of extracts (Chloform, aqueous & methanol) and the standard drug (Piperazine citrate) were tested against Indian adult earthworm. The time taken to paralyze and death time of earthworm was considered for anthelmintic effects. Results: The phytochemical analysis revealed the presence of flavanoids, glycosides, alkaloids, steroids, and tannins. Methanolic extract of P. guajava leave extract was showed significant anthelmintic activity among all extracts. Methanolic extract have been found the highest rate of paralysis (1.8200.242 min) and death (5.5730.315 min) of earthworm against the standard drug Piperazine citrate. Conclusion: The wormicidal activity of P. guajava leaves extract suggests that it could be effective against parasitic infections of humans and validate the traditional use of P. guajava as a natural therapy for treatment of anthelmintic infection.

Keywords: Anthelmintic activity; Psidium guajava; Earthworm; Pheretima posthuma; Ethnomedicine

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Copyright

© 2021 Published by Krupanidhi Educational Trust. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/)

  • 24 November 2021

Year: 2021, Volume: 20, Issue: 3


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