A Review on Extended Release Matrix Tablet

Hamed Barzeh; Bharani S  Sogali; Sepideh Shadvar

doi:10.18579/jpcrkc/2016/15/4/108823

Article

A Review on Extended Release Matrix Tablet

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Journal of Pharmaceutical Research

DOI: 10.18579/jpcrkc/2016/15/4/108823

Year: 2016, Volume: 15, Issue: 4, Pages: 147-152

Original Article

A Review on Extended Release Matrix Tablet

Hamed Barzeh *, Bharani S. Sogali , Sepideh Shadvar

Department of Pharmaceutics, Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram Post, Varthur, Hobli, Bangalore - 560035, India

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Purpose : The aim of the study was to explore the necessity, advantages and different techniques of extended release matrix tablet to achieve continuous delivery of drugs at predictable rate and reproducible kinetics for a preterm delivery and provide a therapeutic amount of a drug to the proper site of the body to achieve promptly and then maintain the desired drug concentration.Approach: Different types of extended release matrix tablet have been explained briefly along with the various formulation which mainly by wet granulation or direct compression method or by dispersion of solid particle within a porous matrix formed by using different polymers like HPMC, guar gum, xanthan gum, pectin, chitosan etc.Finding: The matrix controls the release rate of drug. Release retardants like HPMC can aid in extended release and thus they form core excipient of the formulation. The matrices used may be hydrophilic, hydrophobic, mineral, or biodegradable types. The drug release rate can be studied by in vitro dissolution studies. Some drugs that have been formulated as extended release matrix tablets are Ambroxol HCl, Clarithromycin, Indomethacin etc.Conclusion: The extended release matrix tablets can assure better patient compliance through reduction in total dose and dosage regimen, which can be great help to treat chronic diseases. This review highlights the types of matrices, mechanisms involved and evaluation studies.

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