Journal of Pharmaceutical Research
DOI: 10.18579/jopcr/v25.i3.113
Year: 2026, Volume: 25, Issue: 3, Pages: 173-183
Original Article
Sachin Bhosale1, Aditi Pardeshi1*, Nirmala Shinde1, Kajal Gatkal1
1Department of Pharmaceutical Chemistry, SMBT College of Pharmacy, Nandi-Hills, Dhamangaon, Nashik 422403, Maharashtra, India
*Corresponding Author
Email: [email protected]
The synthesis of MgO nanoparticles is divided into various steps, such as mixing, stirring, filtering, drying, and grinding. Initially (MgNO3.6H2O) of weight 2 g taken into beaker to form 0.2 M solution in distilled water. Then 0.8 g (0.5 M) of NaOH dissolved in 100 ml distilled water. Magnesium nitrate solution stirred for half an hour using magnetic stirrer for constant stirring. Then 0.5 M sodium hydroxide solution was added drop wise by dropper to the prepared Magnesium nitrate (MgNO3.6H2O) Solution while Stirring it continuously. After 30 minutes, milky white color precipitate of Magnesium Hydroxide appeared in beaker. The PH of the solution was 12.5 as measured by the pH paper. Precipitate was filtered by filter paper and washed with methanol three to four times to remove ionic impurities and then dried in air, then after drying white powder sample were annealed in air for two hours at 300 ◦C and 500 ◦C. The dried powder is then crushed and made into very fine powder by using mortal pestle.
Keywords: Magnesium Oxide Nanoparticles, Green synthesis, Co-precipitation method, Tannic acid, UV–Visible and FTIR spectroscopy, X-ray diffraction, Antioxidant and Anti-inflammatory activity, Drug delivery, Biomedical and Pharmaceutical applications
1. Al-saadi TM, Hameed NA. Synthesis and Structural Characterization of Cr2O3 Nanoparticles Prepared by Using Cr(NO3)3.9H2O and Triethanolamine Under Microwave Irradiation. 2015; Available from: https://www.researchgate.net/publication/325393427_Synthesis_and_structural_characterization_of_Cr2O3_nanoparticles_prepared_by_using_Cr_NO3_3_9H2O_and_triethanolamine_under_microwave_irradiation
2. Piriyawong V, Thongpool V, Asanithi P, Limsuwan P. Preparation and Characterization of Alumina Nanoparticles in Deionized Water Using Laser Ablation Technique. Journal of Nanomaterials. 2012; 2012 (1). Available from: https://doi.org/10.1155/2012/819403
3. Bai J, Meng F, Wei C, Zhao Y, Tan H, Liu J. Solution Combustion Synthesis and Characteristics of Nanoscale MgO Powders. Ceramics - Silikaty. 2011; 55 (1). Available from: https://www.researchgate.net/publication/265800817_Solution_Combustion_Synthesis_and_Characteristics_of_Nanoscale_MgO_Powders
4. Mirza F, Makwana H. Synthesis and Characterization of Magnesium Oxide (MgO) Nanoparticles by Co-precipitation Method. International Journal of Innovative Research in Technology. 2021; 8 (6). Available from: https://ijirt.org/article?manuscript=153331
5. Sharma G, Soni R, Jasuja ND. Phytoassisted synthesis of magnesium oxide nanoparticles with Swertia chirayaita. Journal of Taibah University for Science. 2017; 11 (3). Available from: https://doi.org/10.1016/j.jtusci.2016.09.004
6. Senbayram M, Gransee A, Wahle V, Thiel H. Role of magnesium fertilisers in agriculture: plant–soil continuum. Crop & Pasture Science. 2015; 66 (12). Available from: https://doi.org/10.1071/cp15104
7. Dikshit V, Bhudolia S, Joshi S. Multiscale Polymer Composites: A Review of the Interlaminar Fracture Toughness Improvement. Fibers. 2017; 5 (4). Available from: https://doi.org/10.3390/fib5040038
8. Sharma A, Oza G. Nanochemistry. 2023; Ed. 1 Available from: https://doi.org/10.1201/9781003081944
9. Rotti RB, Sunitha D V, Manjunath R, Roy A, Mayegowda SB, Gnanaprakash AP, et al. Green synthesis of MgO nanoparticles and its antibacterial properties. Frontiers in Chemistry. 2023; 11 Available from: https://doi.org/10.3389/fchem.2023.1143614
10. Saidi NSM, Ying KJ, Yusoff HM, Badar N. Synthesis and characterization of magnesium oxide nanoparticles by using banana peel (Musa acuminata Cavendish) extract. Malaysian Journal of Analytical Sciences. 2023; 27 (5). Available from: https://mjas.analis.com.my/mjas/v27_n5/pdf/Mohd%20Saidi_27_5_9.pdf
11. Farani MR, Farsadrooh M, Zare I, Gholami A, Akhavan O. Green Synthesis of Magnesium Oxide Nanoparticles and Nanocomposites for Photocatalytic Antimicrobial, Antibiofilm and Antifungal Applications. Catalysts. 2023; 13 (4). Available from: https://doi.org/10.3390/catal13040642
12. Govindaraj Sudha K, Ali S, Karunakaran G, Kowsalya M, Kolesnikov E, Gorshenkov M V, et al. An eco-friendly production of ZnO NRs using Knema andamanica (Warb) extracts for photocatalytic and anticancer applications. Inorganic Chemistry Communications. 2021; 134 Available from: https://doi.org/10.1016/j.inoche.2021.109030
13. Ali S, Sudha KG, Karunakaran G, Kowsalya M, Kolesnikov E, Rajeshkumar MP. Green synthesis of stable antioxidant, anticancer and photocatalytic activity of zinc oxide nanorods from Leea asiatica leaf. Journal of Biotechnology. 2021; 329 Available from: https://doi.org/10.1016/j.jbiotec.2021.01.022
14. Shahid S, Ejaz A, Javed M, Mansoor S, Iqbal S, Elkaeed EB, et al. The Anti-Inflammatory and Free Radical Scavenging Activities of Bio-Inspired Nano Magnesium Oxide. Frontiers in Materials. 2022; 9 Available from: https://doi.org/10.3389/fmats.2022.875163
15. Das SK, Behera S, Patra JK, Thatoi H. Green Synthesis of Sliver Nanoparticles Using Avicennia officinalis and Xylocarpus granatum Extracts and In vitro Evaluation of Antioxidant, Antidiabetic and Anti-inflammatory Activities. Journal of Cluster Science. 2019; 30 (4). Available from: https://doi.org/10.1007/s10876-019-01571-2
16. Munjal S, Singh A. Synthesis and Characterization of MgO Nanoparticles by Orange Fruit Waste through Green Method. International Journal of Advanced Research in Chemical Science. 2017; 4 (9). Available from: https://doi.org/10.20431/2349-0403.0409005
17. Berger T, Sterrer M, Stankic S, Bernardi J, Diwald O, Kno E. Trapping of photogenerated charges in oxide nanoparticles. Materials Science and Engineering: C. 2005; 25 (5-8). Available from: https://doi.org/10.1016/j.msec.2005.06.013
18. Somanathan T, Krishna VM, Saravanan V. MgO Nanoparticles for Effective Uptake and Release of Doxorubicin Drug: pH Sensitive Controlled Drug Release. Journal of Nanoscience and Nanotechnology. 2016; 16 (9). Available from: https://doi.org/10.1166/jnn.2016.12164
19. Zych M, Hanus R, Vlasák P, Jaszczur M, Petryka L. Radiometric methods in the measurement of particle-laden flows. Powder Technology. 2017; 318 Available from: https://doi.org/10.1016/j.powtec.2017.06.019
© 2026 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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