• P-ISSN 0973-7200 E-ISSN 2454-8405
  • Follow us

Journal of Pharmaceutical Research

Article

Herbal Medicine: A Potential Therapeutic Approach for Breast Cancer in Near Future
  • VIEWS 179
  • PDF 104

Journal of Pharmaceutical Research

DOI: 10.18579/jopcr/v23.1.28

Year: 2024, Volume: 23, Issue: 1, Pages: 16-22

Review Article

Herbal Medicine: A Potential Therapeutic Approach for Breast Cancer in Near Future

Veerappa Hugar1, Daneshwari S Kanashetti2,*, Nayan Kamal Dwevedi3

1MD Scholar, Department of Rasashastra and Bhaishajya Kalpana, Ayurveda Mahavidhyalaya, Hubli, Karnataka, India
2PhD scholar, Department of Dravyaguna,Institute of Medical Sciences, Banaras Hindu University, Varanasi
3Former Dean, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi

*Corresponding author email: [email protected]

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

The use of naturally occurring compounds to stop carcinogenesis is expanding. It has been shown that a variety of herbal extracts and pure active compounds produced exclusively from plants have potent anti-cancer properties. Herbs can play a supportive role in promoting complete recovery, alleviating side effects, and addressing cancer-related issues. Haridra- Curcuma longa, Guduchi- Tinospora cordifolia, Atasi- Linum ussitatissimum, Kalajaji- Nigella sativa, Lashuna- Allium sativum, Ashwagandha- Withania somnifera, Kalamegha- Andrographis paniculata, Trapusha- Podophyllum hexandrum, Shigru- Moringa ptyrygosperma,Bhumyalaki- Phyllanthus niruri, Pippali- Piper longum etc. are various plants having scientific evidence of anticancer property.Numerous in vitro and in vivo studies have suggested that these medications have potential for treating breast cancer. Studies focused on molecular pathways have aided in the discovery of the main therapeutic strategies for treating breast cancer. The focus of future research should be on patient-centered translational trials for breast cancer. These will strengthen the therapeutic effectiveness of our Ayurvedic medication. This review seeks to offer experimental support and a greater understanding of the molecular processes by which various herbs function as chemotherapeutic agents against distinct forms of breast cancer.

Keywords

Anti-cancer, Ayurvedic herbs, Plant based medicine, Breast cancer

References

  1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians. 2021;71(3):209–249. Available from: https://dx.doi.org/10.3322/caac.21660
  3. Cravotto G, Boffa L, Genzini L, Garella D. Phytotherapeutics: an evaluation of the potential of 1000 plants. Journal of Clinical Pharmacy and Therapeutics. 2010;35(1):11–48. Available from: https://dx.doi.org/10.1111/j.1365-2710.2009.01096.x
  4. Orrantia-Borunda E, Anchondo-Nuñez P, Acuña-Aguilar LE, Gómez-Valles FO, Ramírez-Valdespino CA. Subtypes of Breast Cancer. Breast Cancer. 2022.
  5. Dai X, Cheng H, Bai Z, Li J. Breast Cancer Cell Line Classification and Its Relevance with Breast Tumor Subtyping. Journal of Cancer. 2017;8(16):3131–3141. Available from: https://dx.doi.org/10.7150/jca.18457
  6. Choudhuri T, Pal S, Agwarwal ML, Das T, Sa G. Curcumin induces apoptosis in human breast cancer cells through p53‐dependent Bax induction. FEBS Letters. 2002;512(1-3):334–340. Available from: https://dx.doi.org/10.1016/s0014-5793(02)02292-5
  8. Shao Z, Shen Z, Liu C, Sartippour MR, Go VL, Heber D, et al. Curcumin exerts multiple suppressive effects on human breast carcinoma cells. International Journal of Cancer. 2002;98(2):234–240. Available from: https://dx.doi.org/10.1002/ijc.10183
  9. Bachmeier BE, Mirisola V, Romeo F, Generoso L, Esposito A, Dell’Eva R, et al. Reference Profile Correlation Reveals Estrogen-like Trancriptional Activity of Curcumin. Cellular Physiology and Biochemistry. 2010;26(3):471–482. Available from: https://dx.doi.org/10.1159/000320570
  10. Zang S, Liu T, Shi J, Qiao L. Curcumin: A Promising Agent Targeting Cancer Stem Cells. Bentham Science Publishers Ltd.. 2014. Available from: https://dx.doi.org/10.2174/1871520614666140521114735
  12. Annapurna A, Suhasin G, Raju B, Jaya G, Siva C. Anti-cancer activity of Curcuma longa linn.(Turmeric) Journal of Pharmacy Research. 2011;4(4):1274–1280.
  14. Ansari JA, Rastogi N, Ahmad MK, Mahdi AA, Khan AR, Thakur R, et al. ROS mediated pro-apoptotic effects of Tinospora cordifolia on breast cancer cells. Frontiers in Bioscience. 2017;9(1):89–101.
  15. Maliyakkal N, Udupa N, Pai KS, Rangarajan A. Cytotoxic and apoptotic activities of extracts of Withania somnifera and Tinospora cordifolia in human breast cancer cells. International Journal of Applied Research in Natural Products. 2013;6(4):1.
  16. Mishra A, Kumar S, Pandey AK. Scientific Validation of the Medicinal Efficacy of Tinospora cordifolia. The Scientific World Journal. 2013;2013:1–8. Available from: https://dx.doi.org/10.1155/2013/292934
  18. Chen J, Tan KP, Ward WE, Thompson LU. Exposure to Flaxseed or Its Purified Lignan during Suckling Inhibits Chemically Induced Rat Mammary Tumorigenesis. Experimental Biology and Medicine. 2003;228(8):951–958. Available from: https://dx.doi.org/10.1177/153537020322800811
  19. Chen WY, Colditz GA, Rosner B, Hankinson SE, Hunter DJ, Manson JE, et al. Use of Postmenopausal Hormones, Alcohol, and Risk for Invasive Breast Cancer. Annals of Internal Medicine. 2002;137(10):798.
  20. Tan KP, Chen J, Ward WE, Thompson LU. Mammary Gland Morphogenesis is Enhanced by Exposure to Flaxseed or Its Major Lignan During Suckling in Rats. Experimental Biology and Medicine. 2004;229(2):147–157. Available from: https://dx.doi.org/10.1177/153537020422900203
  22. Dastjerdi M, Mehdiabady E, Iranpour F, Bahramian H. Effect of thymoquinone on P53 gene expression and consequence apoptosis in breast cancer cell line. International Journal of Preventive Medicine. 2016;7(1):66. Available from: https://dx.doi.org/10.4103/2008-7802.180412
  23. Shanmugam MK, Ahn KS, Hsu A, Woo CC, Yuan Y, Tan KHB, et al. Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis. Frontiers in Pharmacology. 2018;9:1294. Available from: https://dx.doi.org/10.3389/fphar.2018.01294
  24. Baig WA, Alwosaibai K, Al-Jubran KM, Chaudhry TM, Al-Dowish N, Alsaffar F, et al. Synergistic anti-cancer effects of Nigella sativa seed oil and conventional cytotoxic agent against human breast cancer. Drug Metabolism and Personalized Therapy. 2022;37(3):315–321. Available from: https://dx.doi.org/10.1515/dmpt-2021-0229
  26. Modem S, DiCarlo SE, Reddy TR. Fresh Garlic Extract Induces Growth Arrest and Morphological Differentiation of MCF7 Breast Cancer Cells. Genes & Cancer. 2012;3(2):177–186. Available from: https://dx.doi.org/10.1177/1947601912458581
  27. PS, Anantharaju PG, Veeresh PM, Dey S, Bovilla VR, Madhunapantula SRV. Diallyl Disulfide (DADS) Retards the Growth of Breast Cancer Cells in Vitro and in Vivo Through Apoptosis Induction. Biomedical and Pharmacology Journal. 2017;10(4):1619–1630. Available from: https://dx.doi.org/10.13005/bpj/1273
  28. Challier B, Perarnau JM, Viel JF. Garlic, onion and cereal fibre as protective factors for breast cancer: A French case-control study. European journal of epidemiology. 1998;14:737–784.
  29. Pourzand A, Tajaddini A, Pirouzpanah S, Asghari-Jafarabadi M, Samadi N, Ostadrahimi AR, et al. Associations between Dietary<i>Allium</i>Vegetables and Risk of Breast Cancer: A Hospital-Based Matched Case-Control Study. Journal of Breast Cancer. 2016;19(3):292. Available from: https://dx.doi.org/10.4048/jbc.2016.19.3.292
  30. Wadhwa R, Singh R, Gao R, Shah N, Widodo N, Nakamoto T, et al. Water Extract of Ashwagandha Leaves Has Anticancer Activity: Identification of an Active Component and Its Mechanism of Action. PLoS ONE. 2013;8(10):e77189. doi: 10.1371/journal.pone.0077189
  33. Yang Z, Garcia A, Xu S, Powell DR, Vertino PM, Singh S, et al. Withania somnifera Root Extract Inhibits Mammary Cancer Metastasis and Epithelial to Mesenchymal Transition. PLoS ONE. 2013;8(9):e75069. Available from: https://dx.doi.org/10.1371/journal.pone.0075069
  35. Biswal BM, Sulaiman AM, Ismail HC, Zakaria H, Jalil Abdul MI, Muhammad KI. AOS14 Phase II clinical study of combination chemotherapy with herb Withania somnifera (ashwagandha) in breast cancer. European Journal of Cancer. 2012;48:S8–S9. doi: 10.1016/j.ejca.2012.02.031
  36. Beesetti SL, Jayadev M, Subhashini GV, Mansour L, Alwasel S, Harrath AH. Andrographolide as a therapeutic agent against breast and ovarian cancers. Open Life Sciences. 2019;14(1):462–469. Available from: https://dx.doi.org/10.1515/biol-2019-0052
  37. Peng Y, Wang Y, Tang N, Sun D, Lan Y, Yu Z, et al. Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway. Journal of Experimental Clinical Cancer Research. 2018;37(1):1–4. Available from: https://dx.doi.org/10.1186/s13046-018-0926-9
  38. Chou YJ, Lin CC, Hsu YC, Syu JL, Tseng LM, Chiu JH, et al. Andrographolide suppresses the malignancy of triple-negative breast cancer by reducing THOC1-promoted cancer stem cell characteristics. Biochemical Pharmacology. 2022;206:115327. Available from: https://dx.doi.org/10.1016/j.bcp.2022.115327
  39. Naomi R, Bahari H, Ong ZY, Keong YY, Embong H, Rajandram R, et al. Mechanisms of Natural Extracts of Andrographis paniculata That Target Lipid-Dependent Cancer Pathways: A View from the Signaling Pathway. International Journal of Molecular Sciences. 2022;23(11):5972. doi: 10.3390/ijms23115972
  40. Aftab J, Aziz E, Zulqarnain A, Nasim MT, Sajjad A, Zafar MQ, et al. Study of Anticancer and Antibacterial Activities of Podophyllum Hexandrum as Natural Curatives.
  42. Chattopadhyay S, Bisaria VS, Panda AK, Srivastava AK. Cytotoxicity of in vitro produced podophyllotoxin from podophyllum hexandrum on human cancer cell line. Natural Product Research. 2004;18(1):51–57. Available from: https://dx.doi.org/10.1080/1057563031000122095
  43. Kumbhar PS, Sakate AM, Patil OB, Manjappa AS, Disouza JI. Podophyllotoxin-polyacrylic acid conjugate micelles: improved anticancer efficacy against multidrug-resistant breast cancer. Journal of the Egyptian National Cancer Institute. 2020;32(1):1–8. Available from: https://dx.doi.org/10.1186/s43046-020-00053-1
  44. Al-Asmari AK, Albalawi SM, Athar MT, Khan AQ, Al-Shahrani H, Islam M. Moringa oleifera as an Anti-Cancer Agent against Breast and Colorectal Cancer Cell Lines. PLOS ONE. 2015;10(8):e0135814. Available from: https://dx.doi.org/10.1371/journal.pone.0135814
  45. Gupta RK. Dharmshila Kumari Aniket K. an cancer cell lines. International Journal of Current Research . .
  46. Balogun TA, Buliaminu KD, Chukwudozie OS, Tiamiyu ZA, Idowu TJ. Anticancer Potential of Moringa oleifera on BRCA-1 Gene: Systems Biology. Bioinformatics and Biology Insights. 2021;15. Available from: https://dx.doi.org/10.1177/11779322211010703
  48. Lee SH, Jaganath IB, Atiya N, Manikam R, Sekaran SD. Suppression of ERK1/2 and hypoxia pathways by four Phyllanthus species inhibits metastasis of human breast cancer cells. Journal of Food and Drug Analysis. 2016;24(4):855–865. Available from: https://dx.doi.org/10.1016/j.jfda.2016.03.010
  50. Lai Lh, Fu Qh, Liu Y, Jiang K, Guo Qm, Chen Qy, et al. Piperine suppresses tumor growth and metastasis in vitro and in vivo in a 4T1 murine breast cancer model. Acta Pharmacologica Sinica. 2012;33(4):523–530. doi: 10.1038/aps.2011.209

Copyright

© 2024 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) 

  • 22 May 2024

Year: 2024, Volume: 23, Issue: 1


More articles

DON'T MISS OUT!

Subscribe now for latest articles and news.