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Journal of Pharmaceutical Research

Article

Kigelia Pinnata: Exploration of Potential Medicinal Usage in Human Ailments
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Journal of Pharmaceutical Research

Year: 2016, Volume: 15, Issue: 4, Pages: 138-146

Original Article

Kigelia Pinnata: Exploration of Potential Medicinal Usage in Human Ailments

Abstract

Purpose : The usage of medicinal herbs in the treatment or cure of various human ailments has been reported since past many centuries. Due to less toxicity of herbs when compared with allopathic drug, these are utilized in the development of formulations to increase efficacy. This review explores the various chemical constituents of the plant Kigelia pinnata, commonly called as Sausage tree, and their therapeutic effects in various human ailments.Findings : Kigelia pinnata has been proven to contain many secondary metabolites like alkaloids, glycosides, tannins, saponins, terpenoids, flavonoids, sterols, fatty acids, naphthaquinones, etc. The plant possesses many traditional uses such as anticancer, antileprotic, antimalarial, antibacterial, analgesic and anti-inflammatory, antiurolithiasis, antidiarrhoeal, antioxidant, antidiabetic, etc.Conclusion : Kigelia pinnata is an important plant bearing significant medicinal values in human. This review thus helps the researcher to evaluate and establish the use of plant in various conditions as a curative or as a prophylactic agent and it also highlights the potential of the plant as therapeutic agents in different human ailments.

References

  • Sikder MA, Hossain AK, Parvez MM, Kaisar MA, Nimmi I, Rashid MA. Antioxidant behaviour of two Bangladeshi Medicinal Plants: Kigelia pinnata and Mesua nagasarium. Bangladesh Pharmaceutical Journal. 2011;8(2): 195-197
  • Siddiqui K, Mazumder A, Chakraborthy G. A Review on Phytopharmacological Profile of Kigelia pinnata ( Jacq .). International Journal of Pharma Research & Review. 2015;4 (9):34�8.
  • Gabriel O, Olubunmi A. Comprehensive scientific demystification of Kigelia africana : A review. Pure Appl Chem. 2009;3(9):158�64.
  • Herbal Gram: Sausage Tree Kigelia Pinnata: An Ethnobotanical and Scientific Review. http://cms.herbalgram.org/herbalgram/issue 94/FEAT_sausagetree.html?ts=1454514790 &signature=60634067d4425f1c6efba03afee b2763 (accessed 10.11.2016)
  • Fredrick AC, Ebele OP, Chioma Obi, Utoh�Nedosa UA. Analgesic, Phytochemical and Toxicological investigations of ethanol extract of the leaves of Kigelia africana (Lam.) Benth (family Bignoniaceae )-Sausage Tree. J Pharm Biomed Sci. 2014;04(07):588-595.
  • Kigel ia af r i cana - Sausage Tree. http://www.flowersofindia.net/catalog/slides/ Sausage Tree.html (accessed 10.11.2016)
  • Bhramaramba R, Babu IS, Teja KR, Kumari EK, Rathna KVP. Pharmacognostic and Phytochemical Investigation of Kigelia africana (Lam.) Benth. Fruits. International Journal of Pharmaceutical & Biological Archives. 2012;3(6):1278�82.
  • Gouda YG, Abdel-baky AM, Mohammed KM, Darwish FM, Kasai R Yamasaki K. Phenylpropanoid and phenylethanoid derivatives from Kigelia pinnata DC. Fruits, Nat Prod Res. 2006;20(10):935-39.
  • Atolani O, Olatunji AG. Epicuticular Wax and Volatiles of Kigelia pinnata Leaf Extract. Ethnobotan Leafl. 2010;14:797-806.
  • Saini S, Kaur H, Verma B, Ripudaman, Singh S. Kigelia africana (Lam.) Benth. An overview. Nat Prod Rad. 2009;8(2):190-97.
  • Neelam B, Shailendra S, Fermida N, Amir A. Isolation and in vitro anti amoebic activity of iridoids isolated from Kigelia pinnata. General papers. Arkivoc(x). 2006;69-76.
  • Akah PA. Antidiarrheal activity of Kigelia africana in experimental animals, J Herbs Spices Med Plants. 1998;31-38.
  • Akunyili DN. Houghton PJ. Monoterpenoids and naphthoquinones from Kigelia pinnata bark, Phytochem. 1993;1015-18.
  • Kitagawa I, Fukuda Y, Taniyama T, Yoshikawa M. Chemical studies on crude drug processing. Part 8. On the constituents of Rehmannniae Radix. Part 2. Absolute stereostructures of rehmaglutin C and glut inoside isolated f rom Chinese Rehmanniae Radix, the dried root of Rehmannia glutinoasa Libosch. Chem Pharm Bull 1995;43:1096�100.
  • Govindachari TR, Patankar SJ, Viswanathan N. Isolation and structure of two new dihydroisocoumarins from Kigelia pinnata. Phytochemistry 1971;10:1603�6.
  • Haruji O, Inouye H. Iridoids glycosides of Rehmania glutinosa. Pytochemistry 1981;21: 133�8.
  • Sha'aban F, El-Naggar, RaymondWD. Specioside: a new iridoid glycoside from Catalpa speciosa. J Nat Prod 1980;43:524�6.
  • Von OS, Fatma U, Afifi-Yazar. Minecosid und Verminosid, zwei neue Iridoidglucoside aus Veronica officinalis L. (Scrophulariaceae) Helvitica Chim Acta 1979;62:535�9.
  • Saraswathy A, Purushothaman KK, Patra A, Dey AK, Kundu AB. Shoreaphenol, a polyphenol from Shorea robusta. Phytochemistry 1992;31:2561�2.
  • Anh-Tho N, Jeanine F, HuguesM, Magda C, Michel L, Pierre D. Asugar ester and an iridoid glycoside from Scrophularia ningpoensis. Phytochemistry 2005;66: 1186�91.
  • Yinrong L, Yeap FL. Polyphenolics of Salvia � a review. Phytochemistry 2002;59:117�40.
  • Khan MR, Mlungwana SM, �-Sitosterol. A cytotoxic sterol from Markhamia zanzibarica and Kigelia africana, Fitoterapia. 1999,70(1): 96-97.
  • Govindachari TR, Patankar SJ, Visananthan N. Isolation and structure of two new dihydroisocoumarins from Kigelia pinnata, Phytochemistry, 1971,10603-1606.
  • Joshi KC, Singh P, Taneja S, Cox PJ. New terpenoid aldehydes from Kigelia pinnata: Crystal structure of pinnatal, Tetrahedron. 1982;38:2703-2708.
  • Gouda YG, Abdel-baky AM, Darwish FM, Mohammed KM, Kasai R Yamasaki, K. Iridoids from Kigelia pinnata DC. Fruits, Phytochem. 2003;63(8):887-92.
  • Moideen SVK, Houghton PJ, Rock P, Croft SL, Aboagye-Nyame F. Activity of extracts and naphthoquinones from Kigelia pinnata against Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense. Planta Med. 1999;65(6): 536-540.
  • Houghton PJ, Photiou A, Uddin S, Shah P, Browning M, Jackson SJ. Retsas, S. Activity of extracts of Kigelia pinnata against melanoma and renal carcinoma cell lines. Planta Med. 1994;60(5):430-433.
  • Atolani O, Fabiyi OA, Olatunji GA. Nematicidal isochromane glycoside from Kigelia pinnata leaves. Acta Agric Slov. 2014; 104(1):25�31.
  • Rawat M, Parmar N, Kumar T. Evaluation of Analgesic potential of Kigelia pinnata leaf extract in wistar rat. International Research Journal of Pharmacy 2011;2(10):87-89.
  • Khan MA, Islam M. Analgesic and cytotoxic activity of Acorus calamus L., Kigelia pinnata L., Mangifera indica L. and Tabernaemontana divaricata L. J Pharm Bioallied Sci. 2012; 4(2):149
  • Bole S, Dhritiv V, Chowdhary P, Rahul J, Vishank G. Free radical scavenging and antidiabetic activity of Kigelia pinnata. World Journal of Pharmacy and Pharmaceutical Sciences 2014;3(4):1249-62.
  • Rawat M, Parmar N, Kumar T. Evaluation of Anti-inflammatory potential of Kigelia pinnata leaf extract in Wistar rat. Asian Journal of Pharmaceutical and Clinical Research 2012; 5(1):96-97.
  • Owolabi OJ, Omogbai EK (2007). Analgesic and anti-inflammatory activities of ethanolic stembark extract of Kigelia Africana (Bignoniacea). Afr. J. Biotechnol. 6(5): 582585.
  • Carvalho LH, Rocha EMM, Raslan DS, Oliveira AB, Krettli AU (1988). In Vitro activity of natural and synthetic naphthoquinones against erythrocytic stages of the plasmodium falciparum. Braz. J. Med. Biol. Res. 21: 485487.
  • Emeka G, Emmanuel N, Victor N, Simeon I. Effect of Methanol Leaf and Fruit Extracts of Kigelia africana on Some Biochemical Parameters of Normal Albino Rats. World Appl Sci. 2014;31(10):1689�94.
  • Olubunmi A, Adeyemi SO, Akpan E, Adeosun CB, Olatunji GA. Chemical composition and antioxidant potentials of Kigelia pinnata root oil and extracts. EXCLI J. 2011;10:264�73.
  • Road PM, Nadu T. Biological actions and mechanisms underpinning the Antiurolithiatic effectiveness of various natural herbal compounds. Int J Univers Pharm Bio Sci. 2013;4(6):535�47.
  • Gupta AK, Kothiyal P, Pandey S. Evaluation of Antiurolithiatic potential of Kigelia africana fruits in albino rats. FABAD J Pharm Sci. 2011;36:197�205.
  • Ravindra K, Tirath K, Virender K, Harish C. Pharmacological evaluation of ethanolic extract of Kigelia pinnata fruit against ethylene glycol induced urolithiasis in rats. Asian Journal of Plant Science and Research. 2012; 2 (1):63-72.
  • Hussain T, Fatima I, Rafay M, Shabir S, Akram M, Bano S. Evaluation of antibacterial and antioxidant activity of leaves, fruit and bark of Kigelia africana. Pakistan J Bot. 2016;48(1): 277�83.
  • Jeyachandran R, Mahesh A. Antimicrobial evaluation of Kigelia aricana (Lam). Research Journal of Microbiology. 2007; 2(8):645-49.
  • Momekov G, Momekova D, Pencheva I, Konstantinov S. Antineoplastic activity of a methanolic extract from Kigelia pinnata DC stem bark. J Cancer Ther Res. 2012;1(1):17.
  • Houghton PJ, Photiou A, Uddin S, Shah P, Browning M, Jackson SJ, Retsas S (1994). Activity of extracts of Kigelia pinnata against melanoma and renal carcinoma cell lines. Planta med. 60(5): 430-433.
  • Sainadh NS, Pkm N, C VK, Kulkarni SC. Evaluation of Anti-Cancer Activity of Kigelia africana on EAC Induced Breast Tumors . J Pharm Pharm Sci. 2013;2(3):78�84.
  • Abhishek S, Umesh KS, Umashankar S, Niranjan S, Vimlesh M, Garima Y. Anticonvulsant activity of Kigelia pinnata bark extract. International Journal of Pharmacy and Pharmaceutical Sciences. 2010; 2(4):147-9.
  • Peter AA. Antidiarrheal activity of Kigelia africana in experimental animals. Journal of Herbs Spices & Medicinal Plants. 1996; 4(2):31-38.
  • Owolabi OJ, Omogbai EKI. Studies on the antidiarrhoeal properties of the ethanolic extract of Kigelia africana (bignoniaceae). Pharmacologyonline. 2009; 1:243-51
  • Lal SD, Yadar BK (1983). Folk Medicines of Kurukshetra district (Haryana), India Econ. Bot. 37: 299-305.
  • Grace OM, Davis SD (2002). Kigelia africana (Lam.) Benth. Record from protabase. Oyen LPA, Lemmens RHMJ Wageningen, Netherlands. Inmagic DB/Text Webpublisher PRO: 1 records (http://database.prota.org/ search.htm).
  • Owolabi OJ, Amaechina FC, Eledan AB (2008). Central nervous system Stimulant effect of the ethanolic extract of kigrlia Afr. J. Med. Plant Res. 2(2): 20-23.
  • Kumar S, Kumar V, Prakash OM. Antidiabetic and hypolipidemic activities of Kigelia pinnata flower extract in streptozocin induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine 2012;2(7):543-546.
  • Rai D, Sharma U, Singh A, Kumar M, Agrahari P. Wond healing activity of Kigelia pinnata bark extract Asian Journal of Pharmaceutical and Clinical Research 2010;3(4):74-75.
  • Kigelia Gel- Fast, effective relief for very dry skin conditions. http://www.kigeliagel.com/ other-kigelia-products.html (accessed 10.11.2016).

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