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Journal of Pharmaceutical Research

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Potential Benefits of Tephrosia purpurea in Ana emia and Thrombocytopenia
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Journal of Pharmaceutical Research

DOI: 10.18579/jopcr/v17.3.anuja

Year: 2018, Volume: 17, Issue: 3, Pages: 8-16

Original Article

Potential Benefits of Tephrosia purpurea in Ana emia and Thrombocytopenia

Anuja Ranjan1, Jyothi Y1,∗, Kuntal Das2

1Department of Pharmacology, Krupanidhi College of Pharmacy, Carmelaram, Varthur Hobli, Bengaluru, Karnataka, India
2Department of Pharmacognosy, Krupanidhi College of Pharmacy, Carmelaram, Varthur Hobli, Bengaluru, Karnataka, India

*Corresponding Author
Email: [email protected]

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Objectives: Anaemia is a common nutritional disease characterized by a decrease in haemoglobin and red blood cell (RBC) levels. Thrombocytopenia is a condition in which the platelet count decreases from the normal level and is characterized by excessive bleeding from the mouth, nose, and gums. The methanolic extract of Tephrosia purpurea contains flavonoids that show antioxidant and anti-anaemic activities. In the present study, we investigated the effect of Tephrosia purpurea on phenylhydrazine-induced anaemia and a heparin-induced thrombocytopenic rat model. Methods: The pulverized form of the whole plant was subjected to Soxhlet extraction, followed by phytochemical investigation and antioxidant activity using the DPPH method. Anaemia was induced by phenylhydrazine 60 mg/kg i.p for two days, and then treated with various doses of Tephrosia purpurea (200 400 g/kg p. o.) for 14 days. Parameters like RBC, Hgb, and MCH were measured. Thrombocytopenia was induced with heparin 2000 IU/kg for 10 days, followed by treatment with various doses of Tephrosia purpurea (200-400gm/kg p.o) for 14 days. Various parameters such as platelet count, bleeding time, and clotting time were observed. Findings: Tephrosia purpurea has excellent anti-anaemia and anti-thrombocytopenic activities. There was an increase in RBCs, Hbs, and WBCs in comparison to the phenylhydrazine-induced group, which also showed a dose-dependent increase in haematological parameters. In addition, Tephrosia purpurea showed excellent anti-thrombocytopenic activity. It showed a marked increase in platelets and a decrease in bleeding time and clotting time in comparison to the heparin-induced thrombocytopenia group. Novelty: Tephrosia purpurea has potential and can be considered the drug of choice for the management of anaemia and thrombocytopenia.

Keywords: Tephrosia purpurea, Anti­anaemic activity, Anti­thrombocytopenic

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Copyright

© 2018 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) 

  • 22 September 2024

Year: 2018, Volume: 17, Issue: 3


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