S. Angayer Kanchana *, Aruna Ajithadas , V. Niraimathi , A. Jerad Suresh
- Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, India
Abstract
Four new simple, accurate and precise spectrophotometric methods have been developed for simultaneous determination of telmisartan and amlodipine in pharmaceutical dosage form. Method A involves formation and solving of simultaneous equation using 299nm and 364nm as two wavelengths. Method B involves formation of Q-absorbance equation at 339nm (iso absorptive point) and at 299nm (?max of telmisartan). Method C involves first order derivative method for simultaneous estimation of these two drugs. Method D involves the AUC for first order derivative spectrum. Both the drugs obey the Beer's law in the range 5-50?g/mL for amlodipine and 5-40?g/mL for telmisartan. The results of analysis have been validated statistically and by recovery studies.
