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Journal of Pharmaceutical Research

Article

A Novel Estimation of Nicorandil in Bulk and Oral Solid Dosage form by Spectrophotometry
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Journal of Pharmaceutical Research

Year: 2012, Volume: 11, Issue: 2, Pages: 67-70

Original Article

A Novel Estimation of Nicorandil in Bulk and Oral Solid Dosage form by Spectrophotometry

Abstract

Two simple, validated and sensitive spectrophotometric methods have been developed for the estimation of nicorandil in bulk and in pharmaceutical formulation (Method A&Method B). The method A involves the determination of nicorandil by standard absorbance method at 262 nm which obeys Beer's law in concentration range of 20-120 � g/mL. Method B is based on the formation of intensely yellow ammonium salts by the interaction of nicorandil with phenol-2,4-disulphonic acid which obeys Beer's law in concentration range of 10-60 ?g/ml exhibiting maximum absorption at 405 nm under the optimized experimental conditions. The results obtained by the proposed method are acceptable. The methods were extended to tablet formulation and there was no interference from excipients and diluents. These methods have been statistically validated and are found to be precise and accurate.

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