• P-ISSN 0973-7200 E-ISSN 2454-8405
  • Follow us

Journal of Pharmaceutical Research

Article

Design and Characterization of Buccal Films of Benzocaine for Mouth Ulcer
  • VIEWS 3373
  • PDF 1381

Journal of Pharmaceutical Research

DOI: 10.18579/jopcr/v20i3.ms21062

Year: 2021, Volume: 20, Issue: 3, Pages: 9-17

Original Article

Design and Characterization of Buccal Films of Benzocaine for Mouth Ulcer

Jiji Jose1,*, M V Sisira1, M L Lal Prasanth1, C R Shibu Prasanth1, P S Pradeep2

1DM WIMS College of Pharmacy, Meppadi Post, Wayanad, Kerala, India
 2DM WIMS Medical College, Meppadi Post, Wayanad, Kerala, India

*Corresponding Author Email: [email protected]

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Mouth ulcer is very common in recent years, which occurs due to the damage of epithelial tissue and/or lamina propria that finally leads to tissue necrosis. Benzocaine has been used to treat the mouth ulcers due to its excellent local anaesthetic effect that relieves the pain associated with mouth ulcer. Hence an attempt was made to develop and characterize the buccal films of Benzocaine to treat mouth ulcers with an aim of prolonging the drug release and improving the patient convenience. The films were fabricated using the mucoadhesive polymer blend of chitosan and HPMC by solvent casting method and the physico-mechanical, in vitro drug release and ex vivo buccal mucosal permeation characteristics of the films were studied. All fabricated film formulations prepared were smooth and almost opaque, with good flexibility. The weight and thickness of all the formulations were found to be uniform. Drug content in the films ranged from 97–99%, indicating favorable drug loading and uniformity. The inclusion of HPMC, significantly reduced the bioadhesive strength and in vitro mucoadhesion time of chitosan films, although the degree of swelling increased. In vitro drug release and permeation studies in simulated saliva showed a prolonged release for a period of 6 h for all formulations. The formulation with Chitosan: HPMC ratio 1:1, 10% w/w polysorbate 80 and 10% w/w propylene glycol as plasticizers showed the best results which exhibited the cumulative percentage drug release of 87.9 % and the cumulative amount of drug permeation of 7.62mg/cm2 across goat buccal mucosa in 6 h. Drug-excipient interaction studies were carried out using DSC and FT-IR technique; films indicated no chemical interaction between drug and polymers used.

 Keywords: Benzocaine; mouth ulcer; mucoadhesion; buccal film

References

  1. BS, PS, Kannan K. Oral Ulcers - A Review. Journal of Dentistry & Oral Disorders. 2018;4(4):1098–1099. Available from: https://dx.doi.org/10.26420/jdentoraldisord.2018.1098
  3. Tarakji B, Gazal G, Al-Maweri SA, Azzeghaiby SN, Alaizari N. Guideline for the Diagnosis and Treatment of Recurrent Aphthous Stomatitis for Dental Practitioners. J Int Oral Health. 2015;7(5):74–80. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4441245/
  4. Tripathi KD. Essentials of Medical Pharmacology (8th ). (Vol. 2021, pp. 393-394) Jaypee Brothers Medical Publishers (P) Ltd. 2021.
  5. Pramod S, Vijay S, Chandrkant M. Buccal Film: An Innovative Dosage Form Designed to Improve Patient Compliance. International journal of Pharmaceutical and Chemical Sciences. 2012;1(4):1606–1622. Available from: https://ijpcsonline.com/files/files/9-242.pdf
  7. Mathiowitz E. Bioadhessive drug delivery systems. (p. 341) 1995.
  8. Koland M, Vijayanarayana K, Charyulu R, Prabhu P. In vitro and in vivo evaluation of chitosan buccal films of ondansetron hydrochloride. International Journal of Pharmaceutical Investigation. 2011;1(3):164–171. Available from: https://dx.doi.org/10.4103/2230-973x.85967
  9. Aswathy P, RA, RR, Anil A, Surendran SA. Development and Characterization of Buccal Film: Tacrolimus as A Model Drug. J Med Biomed Applied Sci. 2019;7(1):207–211. doi: 10.15520/jmbas.v7i1.176
  10. Kulkarni R. The Eastern pharmacist. (Vol. 43, pp. 109-112) 2000.
  11. DK. The Eastern Pharmacist. (Vol. 42, pp. 97-100) 1998.
  12. Sankar V, Johnson DB, Sivanand V, Veerasamy R. Design and evaluation of nifedipine transdermal patches. Indian J Pharm Sci. 2003;65(5):510–515.
  13. Koteshwar KB, Udupa N, Kumar V. Design and Evaluation of Captropril Transdermal Preparation. Indian Drugs. 1992;29(15):680–685.
  14. Seth AK. Indian Drugs. 1985;23(1):45–47.
  15. Jose J, R N, Mathew M. Transdermal Delivery of Felodipine from Eudragit film. Am. J. PharmTech Res. 2013;3(2):517–531. Available from: https://dx.doi.org/10.9740/mhc.n178409
  16. Peh KK. J Pharm Sci. 1999;2(3):53–61.
  17. Mitra J. J Pharm Sci. 2006;2(4):185–194.
  18. Shiledar RR, Tagalpallewar AA, Kokare CR. Formulation and in vitro evaluation of xanthan gum-based bilayered mucoadhesive buccal patches of zolmitriptan. Carbohydrate Polymers. 2014;101:1234–1242. Available from: https://dx.doi.org/10.1016/j.carbpol.2013.10.072
  19. Salehi S. Prog Biomater. 2017;6:175–187.
  20. Bahri-Najafi R. Res Pharm Sci. 2014;9:213–223.
  21. Perioli L. J Control Release. 2004;97:269–279.
  22. Ilango R. Indian J Pharm Sci. 1997;59:232–235.
  23. Thomas AE. J Clin Diagn Res. 2017;42(1):8–14.
  24. Fernandes FP. Int J Polymer Sci. 2018;2403802:1–10.
  25. Shinde AJ. Int J Pharm Sci Res. 2018;9(5):1797–1805.
  26. Joshua R. Int J Pharm Sci Rev Res. 2017;42(1):8–14.
  27. Semalty A, Semalty M, Nautiyal U. Formulation and evaluation of mucoadhesive buccal films of enalapril maleate. Indian Journal of Pharmaceutical Sciences. 2010;72(5):571. Available from: https://dx.doi.org/10.4103/0250-474x.78522

Copyright

© 2021 Published by Krupanidhi Educational Trust. This is an open access article under the CC BY license. (https://creativecommons.org/licenses/by/4.0/)

  • 25 November 2021

Year: 2021, Volume: 20, Issue: 3


More articles

DON'T MISS OUT!

Subscribe now for latest articles and news.