Bimlesh Chaudhary *, Y. Jyothi , S. I. Rabbani
- Department of Pharmacology, Krupanidhi College of Pharmacy, Chikkabellandur Carmelaram Post, Bengaluru- 560035, Karnataka, India
Abstract
Purpose:To study the potential effect of Asparagus racemosus extract on experimental anemic and thrombocytopenic condition in rats.Approach: The anti-anemic and anti-thrombocytopenic activities of chloroform:methanol (2:1) extract of Asparagus racemosus was studied using phenylhydrazine and heparin-induced models, respectively. Three doses of Asparagus racemosus viz., 250, 500 and 750 mg/kg (p.o, daily for 10 days) were tested in rats, and observations such as levels of RBC count, haemoglobin, mean corpuscular haemoglobin (MCH), WBC, bleeding time and clotting time were recorded. Ferrous sulphate and prednisolone were used as standard agents for anti-anemic and anti-thrombocytopenic activities, respectively.Finding: The anti-anemic study indicated that Asparagus racemosusextract at 750 mg/kg (p<0.01) increase significantly the number of RBC, Hb and significantly decrease (p<0.01) MCH and WBC when compared with anaemic group. In anti-thrombocytopenic study, extract at 750 mg/kg decreased significantly (p<0.01) bleeding time and clotting time compared to heparin group. Our observations indicated that root extract of Asparagus racemosuspossess exhibited anti-anemic and antithrombocytopenic properties and these could be related to the phytoconstituents such as alkaloids, saponins, phytosterols, triterpenoids, polyphenols, carbohydrate, flavonoids, glycosides, phenolic compounds and tannins present in the extract.Originality: The present study is the first time evaluation of the anti-anemic and anti-thrombocytopenic effect of Asparagus racemosus.Conclusion: from our study Asparagus racemosus possess exhibited anti-anemic and anti-thrombocytopenic properties.
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