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Journal of Pharmaceutical Research

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Pharmaceutical Co-crystals: A Review on its Physico-chemical Properties and Role in the Management of Cancer
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Journal of Pharmaceutical Research

DOI: 10.18579/jopcr/v23.1.74

Year: 2024, Volume: 23, Issue: 1, Pages: 1-6

Review Article

Pharmaceutical Co-crystals: A Review on its Physico-chemical Properties and Role in the Management of Cancer

Manoleena Sarkar1, Rajnandan Borah1, Rajat Das1,*, , Pallab Ghosh1, Chandrika Sharma1, Jyochhana Priya Mohanty1

1Department of Pharmacognosy, Himalayan Pharmacy Institute, Majhitar, E. Sikkim, 737136

*Corresponding author email: [email protected]

Creative Commons License

Abstract

Academic and industry researchers are becoming more interested in pharmaceutical cocrystals as they emerge as a new class of solid pharmaceuticals with enhanced physico-chemical features. Pharmaceutical co-crystal formation is a simple method for significantly altering a therapeutic substance's solid-state characteristics namely its solubility and consequently bioavailability. A drug's physico-chemical properties can be adjusted by a cocrystal between an active pharmaceutical ingredient (API) and co-former without altering the drug's molecular structure. Numerous types of co-crystals, nano co-crystals and co-crystal-loaded nanocarriers have shown significant promise in the fight against cancer through enhanced pharmacokinetic capabilities, decreased toxicities and improved physico-chemical properties. In this review the physico-chemical properties of co-crystals along with its impact in management of cancer have been demonstrated.

Keywords

Co-Crystals, Physicochemical, Co-Former, Bioavailability, Nanocarriers

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Copyright

© 2024 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) 

  • 22 May 2024

Year: 2024, Volume: 23, Issue: 1


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