Journal of Pharmaceutical Research
DOI: 10.18579/jopcr/v25.i4.161
Year: 2026, Volume: 25, Issue: 4, Pages: 246-251
Original Article
Pasham Uma1*, Cheruku Sowmya2, Jatavath Srilatha2, Guntala Bhavana2, Guguloth Pavan Kalyan2, Gujjula Varsha2
1Assistant Professor, Department of Pharmacology, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Hyderabad, 500100, Medchal District, Telangana, India
2Department of Pharmacology, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Hyderabad, 500100, Medchal District, Telangana, India
*Corresponding Author
Email: [email protected]
Medicinal plants are a very important source of bioactive chemicals that could be used to make safer alternatives to manufactured medications. Bougainvillea spectabilis Willd., commonly utilized in traditional medicine, has not been well investigated for its anticoagulant and anthelmintic effects. The current study aimed to analyse the phytochemical composition and examine the Bougainvillea spectabilis aqueous floral extract's (AEBSF) anthelmintic and anticoagulant qualities in vitro. Water maceration was used to extract the flowers after they were collected, checked, and shade-dried. The presence of pharmacologically relevant compounds, including flavonoids, tannins, saponins, alkaloids, glycosides, phenolic compounds, steroids, and sterols, was confirmed by preliminary phytochemical screening. By extending the prothrombin time to 303.01 ± 19.85 s, which was equivalent to the standard EDTA (323.00 ± 31.97 s), the aqueous flower extract of Bougainvillea spectabilis demonstrated strong anticoagulant action. At 20 and 40 mg/mL, the extract also demonstrated concentration-dependent anthelmintic action, causing Pheretima posthuma to become paralyzed and die, however this activity was marginally less than that of albendazole. These findings suggest that the extract possesses promising anticoagulant and anthelmintic properties due to its bioactive phytoconstituents.
Keywords: Bougainvillea spectabilis Willd; Anticoagulant activity; Anthelmintic activity; Phytochemical screening; Medicinal plants
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© 2026 Published by Krupanidhi College of Pharmacy. This is an open-access article under the CC BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/)
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